Journal of Oral Implantology February 2012 - (Page 11)

RESEARCH Correlation Between Surface Hydrophilicity and Osteoblastic Differentiation on Microgrooved Titanium Substrata Suk-Won Lee, DDS, PhD1 Myung-Hyun Lee, PhD2 Namsik Oh, DDS, PhD3* Jung-Ae Park, DDS, MSD4 Richard Leesungbok, DDS, PhD1 Su-Jin Ahn, DDS, PhD1 Surface microgrooves and acid etching on titanium (Ti) have been proposed to enhance various cell behaviors. In this study, surface hydrophilicity, protein adsorption, and alkaline phosphatase activity of osteoblasts were analyzed and compared between microgrooved Ti, Ti with microgrooves and further acid etching, smooth Ti, and acid-etched smooth Ti. Correlations between the results of each experiment were analyzed using Pearson’s correlation analysis, and the influential factor on alkaline phosphatase activity was determined using multiple stepwise regression analysis. Among groups, the Ti substrata with microgrooves and subsequent acid etching showed significantly greater surface hydrophilicity and alkaline phosphatase activity compared with smooth Ti, whereas the Ti substrata with only microgrooves showed the greatest protein adsorption. Multiple stepwise regression analysis determined the surface hydrophilicity of Ti as the influential factor on alkaline phosphatase activity. This study indicates that surface microgrooves and acid etching on Ti substrata enhance surface hydrophilicity, leading to increased alkaline phosphatase activity. Key Words: titanium, microgrooves, surface hydrophilicity, alkaline phosphatase activity INTRODUCTION Department of Biomaterials & Prosthodontics, Kyung Hee University Hospital at Gangdong, Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea. 2 Energy Materials Center, Green Ceramics Division, Korea Institute of Ceramic Engineering and Technology, Seoul, Republic of Korea. 3 Division of Prosthodontics and Implantology, Department of Dentistry, College of Medicine, Inha University, Incheon, Republic of Korea. 4 Department of Prosthodontics, Graduate School of Dentistry, Kyung Hee University, Seoul, Republic of Korea. * Corresponding author, e-mail: onsdo@inha.ac.kr DOI: 10.1563/AAID-JOI-D-09-00144.1 1 o enhance cell responses to biomaterial surfaces, various methods of surface treatments have been introduced. One of these methods consisted of providing microstructural topographies to extensively alter cell shape,1,2 which would further change cell adhesion and proliferation.3,4 As to the osteoblasts cultured on biomaterial surfaces, cell number was verified to be Journal of Oral Implantology 11 T

Table of Contents for the Digital Edition of Journal of Oral Implantology February 2012

A Fluent Electronic Support and Clinical Care Letters: New Formats and More Interactivity Between Journal of Oral Implantology and Its Readers
Dental Implants Immediate Loading Versus the Standard 2-Staged Protocol: An Experimental Study in Dogs
Correlation Between Surface Hydrophilicity and Osteoblastic Differentiation on Microgrooved Titanium Substrata
Analyzing the Effects of the Platform-Switching Procedure on Stresses in the Bone and Implant-Abutment Complex by 3-Dimensional Fem Analysis
Detection of the Mandibular Canal and the Mental Foramen in Panoramic Radiographs: Intraexaminer Agreement
Use of Intraoral Welding to Stabilize Dental Implants in Augmented Sites for Immediate Provisionalization: A Case Report
Maxillary Sinus Augmentation With Autogenous Tibial Bone Graft as an In-Office Procedure
Influence of Prognostic Risk Indicators on Osseointegrated Dental Implant Failure: A Matched Case-Control Analysis
Full Mouth Rehabilitation With Dental Implants for a Patient With Skeletal Class III Malocclusion: A Case Report
Removal of Fractured Implants Using the Apicoectomy Technique and Immediate Replacement With New Implants: Case Report
Reconstruction of a Patient With Rosai-Dorfman Disease Using Ramus Graft and Osseointegrated Implants: A Case Report
Immediate Loading in Mandible Full-Arch: Pilot Study in Patients With Osteoporosis in Bisphosphonate Therapy
Natural Tooth Versus Implant: A Key to Treatment Planning

Journal of Oral Implantology February 2012

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