Journal of Oral Implantology February 2013 - (Page 3)

RESEARCH Vertical Bone Augmentation With Simultaneous Implant Placement Using Particulate Mineralized Bone and Mesenchymal Stem Cells: A Preliminary Study in Rabbit Arash Khojasteh, DMD, MS1 Mohamadreza Baghaban Eslaminejad, PhD2* Hamid Nazarian, MSc2 Golnaz Morad, DDS3 Seyyedeh Ghazaleh Dashti, DDS3 Hossein Behnia, DMD, MS4 Mark Stevens, DMD, MS5 This study aimed to assess vertical bone augmentation with simultaneous implant placement in rabbit tibiae using particulate mineralized bone/fibrin glue/mesenchymal stem cell. Bone marrow was aspirated from tibiae of five 10week-old New Zealand White male rabbits. Right and left tibiae of each rabbit were prepared, and a 3-mm protruding implant from tibial bone was placed in each side. Particulate allogenic bone/fibrin glue/mesenchymal stem cell combination was placed around test implants and particulate bone graft/fibrin glue around controls. Two months postoperatively, the animals were euthanized, and sections were prepared for histological analysis. The mean amount of vertical bone length was higher in the experimental group than the control group (2.09 mm vs 1.03 mm; P , .05). New supracrestal trabecular bone formation was also significantly higher in the test group (28.5 6 4.5% vs 4.3 61.8%; P , .05). Mesenchymal stem cell/particulate allograft/fibrin glue appears to be a promising combination for vertical bone augmentation around simultaneously inserted implants in rabbit tibia. Key Words: mesenchymal stem cell, bone regeneration, dental implant, vertical augmentation INTRODUCTION T 1 he growing science of hard-tissue engineering has introduced various principles and solutions to confront the challenge of bone reconstruction. The process of bone augmentation is mandatory for Department of Oral and Maxillofacial Surgery, Dental Faculty, and Division of Basic Sciences, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2 Department of Stem Cell and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. 3 Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4 Department of Oral and Maxillofacial Surgery, Iranian Center of Dental Research, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5 Medical College of Georgia, Department of Oral and Maxillofacial Surgery, Augusta, Georgia. * Corresponding author, email: eslami@royaninstitute.org DOI: 10.1563/AAID-JOI-D-10-00206 successful placement and integration of root form dental implants in atrophic jaws. Although different techniques have achieved a predictable amount of horizontal bone gain, vertical augmentation has proven to be a consistent challenge, with often less than desirable results.1 This is especially evident in the posterior mandible, where the inferior alveolar nerve further accentuates the limited amount of available bone height.2 Because of this lack of predictability, a large range of reconstructive techniques and materials have been used: onlay bone grafting, guided bone regeneration (GBR), and distraction osteogenesis to list a few. The advantages and disadvantages of each technique impart its applicability to particular circumstances.3,4 The gold standard, autogenous bone graft, has several shortcomings, namely, its availability, its occasional poor quality, and the need for a second surgical site, Journal of Oral Implantology 3

Table of Contents for the Digital Edition of Journal of Oral Implantology February 2013

Could the Fountain of Youth Be All in Your Bones?
Vertical Bone Augmentation With Simultaneous Implant Placement Using Particulate
Evaluation of the Bone Healing Process Utilizing Platelet-Rich Plasma Activated by Thrombin
Effect of Model Parameters on Finite Element Analysis of Micromotions in Implant Dentistry
Peri-Implant Defect Augmentation With Autogenous Bone: A Study in Beagle Dogs
Would Nitric Oxide be an Effective Marker for Earlier Stages of Peri-Implant Disease? An
The Effect of Different Surface Treatments on Cement-Retained Implant-Supported
Effect of Rotating Osteotomes on Primary Implant Stability—An In Vitro Investigation
Horizontal Augmentation Through the Ridge-Split Procedure: A Predictable Surgical
The Bis-Acryl Stent
Clinical, Histological, and Histomorphometrical Analysis of Maxillary Sinus Augmentation
A Technique to Salvage a Single Implant-Supported Fixed Dental Prosthesis Having a
Ridge Expansion and Immediate Placement With Piezosurgery and Screw Expanders in
Pterygoid Implants for Maxillofacial Rehabilitation of a Patient With a Bilateral Maxillectomy
Technology in Maxillary Premolar Region: A New Strategy for Soft Tissue Management
Fracture of Anterior Iliac Crest Following Bone Graft Harvest in an Anorexic Patient: Case
A Technique for Constructing a New Maxillary Overdenture to a Nonretrievable Implant
Edentulous Maxillary Arch Fixed Implant Rehabilitation Using a Hybrid Prosthesis Made of

Journal of Oral Implantology February 2013