Journal of Oral Implantology February 2013 - (Page 37)

RESEARCH Would Nitric Oxide be an Effective Marker for Earlier Stages of Peri-Implant Disease? An Analysis in Human Peri-Implant Sulcular Fluid Andreia Espindola Vieira, MS Camilla Christian Gomes Moura, PhD* Maria Aparecida de Souza, PhD Darceny Zanetta-Barbosa, PhD Paula Dechichi, PhD Nitric oxide has an important effect on host immune response. However, little has been studied in relation to its potential as a possible diagnostic tool in peri-implant disease. The present study analyzed nitrite levels in the peri-implant sulcular fluid (PISF) of implants with mucositis and the correlation of these nitrite levels with clinical parameters using a simplified fluid collection methodology. Twenty-five partially edentulous patients showing peri-implant mucositis were evaluated, and the peri-implant status was determined based on current clinical parameters: probing depth (PD) and bleeding on probing (BOP). The sulcular fluid (SF) around teeth (control) and implants were collected, and the nitrite levels were evaluated using the Griess method. The mean probing depth (mm) was significantly higher (P , .0001) in implants (2.852 6 0.6484) than in control teeth (1.585 6 0.3636). The mean total nitrite level (lM) was statistically higher (P ¼ .0069) in implants with mucositis (14.34 6 11.83) than in control teeth (9.316 6 5.534). No correlation was observed between the total nitrite levels and the PD mean in the control group (P ¼ .2558, r ¼À0.2361) or in the implant group (P ¼ .1160, r ¼À0.3224), as well as the number of faces showing bleeding on probing (P ¼ .8747, r ¼ 0.0332). These results demonstrated that the nitrite levels were higher in inflamed areas. According to the methodology applied and results obtained, the higher nitrite levels in inflamed areas suggest that, in the future, nitrite could be used as a marker of periimplant mucositis associated with clinical data to monitor the cure or evolution of the disease. Key Words: dental implant, diagnosis, peri-implant sulcular fluid, peri-implant mucositis, nitrite INTRODUCTION I n modern dentistry, endosseous oral implants have become an important therapeutic modality for replacing missing teeth. The success rate is high, and long-term studies have shown low rates of oral implant failures.1–4 Despite this high success rate, early failures may occur as a result of lack of osseointegration due to interference with the healing process. Late failures ˆ ˆ Universidade Federal de Uberlandia, Uberlandia, Minas Gerais, Brazil * Corresponding author, e-mail: camillachristiam@hotmail.com DOI: 10.1563/AAID-JOI-D-11-00158 may occur when the achieved osseointegration is lost after a period of function due to periimplantitis, occlusal overload, or implant fracture. Thus, optimal oral hygiene and proper occlusion are considered critical to the long-term success of endosseous oral implants. The monitoring of dental implants is crucial for the prevention or early detection of inflammation since it progresses more rapidly in implant sites than in teeth.5–7 In general, peri-implant health is evaluated using a variety of clinical tools and imagebased methods.7 The frequent clinical measures applied include radiographs, bleeding on probing, Journal of Oral Implantology 37

Table of Contents for the Digital Edition of Journal of Oral Implantology February 2013

Could the Fountain of Youth Be All in Your Bones?
Vertical Bone Augmentation With Simultaneous Implant Placement Using Particulate
Evaluation of the Bone Healing Process Utilizing Platelet-Rich Plasma Activated by Thrombin
Effect of Model Parameters on Finite Element Analysis of Micromotions in Implant Dentistry
Peri-Implant Defect Augmentation With Autogenous Bone: A Study in Beagle Dogs
Would Nitric Oxide be an Effective Marker for Earlier Stages of Peri-Implant Disease? An
The Effect of Different Surface Treatments on Cement-Retained Implant-Supported
Effect of Rotating Osteotomes on Primary Implant Stability—An In Vitro Investigation
Horizontal Augmentation Through the Ridge-Split Procedure: A Predictable Surgical
The Bis-Acryl Stent
Clinical, Histological, and Histomorphometrical Analysis of Maxillary Sinus Augmentation
A Technique to Salvage a Single Implant-Supported Fixed Dental Prosthesis Having a
Ridge Expansion and Immediate Placement With Piezosurgery and Screw Expanders in
Pterygoid Implants for Maxillofacial Rehabilitation of a Patient With a Bilateral Maxillectomy
Technology in Maxillary Premolar Region: A New Strategy for Soft Tissue Management
Fracture of Anterior Iliac Crest Following Bone Graft Harvest in an Anorexic Patient: Case
A Technique for Constructing a New Maxillary Overdenture to a Nonretrievable Implant
Edentulous Maxillary Arch Fixed Implant Rehabilitation Using a Hybrid Prosthesis Made of

Journal of Oral Implantology February 2013