Journal of Oral Implantology October 2013 - (Page 551)
RESEARCH
A Pig Model for the Histomorphometric Evaluation of
Hard Tissue Around Dental Implants
¨ ¨
Ozgur Erdogan, DDS, PhD1*
¨ ¨
Yakup Ustun, DDS, PhD2
Ufuk Tatli, DDS, PhD1
Ibrahim Damlar, DDS1
Kenan Daglıoglu, VMD, PhD3
This study aimed to evaluate the frontal bone of Swiss Domestic pigs as an animal model for the histologichistomorphometric examination of bony tissue around dental implants. We inserted SLA surface implants 4.1
mm in diameter and 10 mm in length into the frontal bones of 9 Swiss-Domestic pigs. Histologic and
histomorphometric studies were conducted on the undecalcified sections. Histologic examinations showed that
the specimens contain a sufficient amount of bone to provide homogenous bone coverage for standard
diameter dental implant placement. The mean bone to implant contact was 61.9% 6 8.7%. Other
histomorphometric parameters revealed the regular trabecular architecture at this site. Pigs’ frontal bone
appears to be a suitable animal model in short-term dental implant studies because it provides a sufficient
amount of bone and favorable bone microarchitecture.
Key Words: dental implants, osseointegration, animal model, histomorphometry, frontal bone
INTRODUCTION
A
nimal studies constitute the main
component of histologic-histomorphometric research in implant dentistry. Since the introduction of dental
implants to the market, many animal
studies have been published and are still been
conducted for the improvement of today’s dental
implant technology.
Determination of the conformity of a new
biomaterial or newly designed implant depends
on the data retrieved from the animal studies
before using the implant is used in clinical practice.
Animal studies regarding dental implants are mostly
performed on monkeys (macaques and baboons),
rabbits, sheep, goats, pigs/mini pigs, and dogs.1–4
1
Department of Oral and Maxillofacial Surgery, Faculty of
Dentistry, Cukurova University, Adana, Turkey.
¸
2
Private Practice, Oral and Maxillofacial Surgery, Adana, Turkey.
3
Experimental Medical Research Center, Cukurova University,
¸
Adana, Turkey.
* Corresponding author, e-mail: ozgerdogan@yahoo.com
DOI: 10.1563/AAID-JOI-D-11-00009
When the hard tissue around dental implants is
to be evaluated, both intraoral and extraoral
implantations can be done. Implants should be
placed into the safest place, so there will be no or
few implant failures and a maximum number of
specimens for the histologic or histomorphometric
examinations. In addition, the bone architecture of
the selected animal model should closely resemble
human jaw bones, so a comparable healing
response can be obtained. Maxillofacial bones of
monkey and dog species are being used for dental
implant studies to some degree, and they are
considered as good representative for human
maxillofacial bones.5,6 However, it is difficult to
use monkeys and dogs because of the need to
obtain ethical approval and the increased cost.
Therefore, researchers often opt to study small
animals such as rabbits. Because the amount of
bone at the maxillofacial region of small animals is
inadequate for dental implant studies, the anatomic
site of choice is usually an extremity bone. However,
long bones such as tibia or femur have the
disadvantage of having endochondral bone origiJournal of Oral Implantology
551
Table of Contents for the Digital Edition of Journal of Oral Implantology October 2013
Food and Drug Administration: Reclassification of Blade Form Dental Implants
Optimizing Platelet-Rich Plasma Gel Formation by Varying Time and Gravitational Forces During Centrifugation
Effect of Surface Roughness and Low-Level Laser Therapy on Removal Torque of Implants Placed in Rat Femurs
Impression Techniques for Multiple Implants: A Photoelastic Analysis. Part I: Comparison of Three Direct Methods
Impression Techniques for Multiple Implants: A Photoelastic Analysis. Part II: Comparison of Four Acrylic Resins
A Pig Model for the Histomorphometric Evaluation of Hard Tissue Around Dental Implants
In Situ Tooth Replica Custom Implant: A 3-Dimensional Finite Element Stress and Strain Analysis
Influence of Different Soft Liners on Stress Distribution in Peri-Implant Bone Tissue During Healing Period. A 3D Finite Element Analysis
Influence of Surface Nano-Roughness on Osseointegration of Zirconia Implants in Rabbit Femur Heads Using Selective Infiltration Etching Technique
Modified Titanium Surfaces Alter Osteogenic Differentiation: A Comparative Microarray- Based Analysis of Human Mesenchymal Cell Response to Commercial Titanium Surfaces
Hemorrhage Secondary to Interforaminal Implant Surgery: Anatomical Considerations and Report of a Case
Rehabilitation of a Patient With Mandibular Resection Using Osteointegrated Implants: A Case Report
Two-Stage Bone Expansion Technique Using Spear-Shaped Implants Associated With Overlapped Flap: A Case Report
Implant Esthetic Restoration in Ridge Deficiencies in Cases of Trauma: A Case Report
Rehabilitation of the Atrophic Maxilla With Tilted Implants: Review of the Literature
Journal of Oral Implantology October 2013
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