Journal of Oral Implantology April 2014 - (Page 169)

RESEARCH Saliva Versus Peri-implant Inflammation: Quantification of IL-1b in Partially and Totally Edentulous Patients Flaviana Soares Rocha, DDS, MSc1* Rainde Naiara Rezende Jesus, DDS2 Fabiana Maria Soares Rocha, DDS2 Camilla Cristhian Gomes Moura, DDS, MSc, PhD3 Darceny Zanetta-Barbosa, DDS, MSc, PhD4 The aim of this study was to investigate the potential use of salivary IL1b in early-stage diagnostics of periimplant inflammation in partially and totally edentulous patients rehabilitated with dental implants. Patients were classified according to peri-implant probing depth and bleeding upon probing in groups of healthy individuals or in groups of individuals with peri-implant inflammation. Data on plaque index, clinical attachment loss, suppuration, and mobility were also assessed. Saliva was collected without stimulation, and the levels of IL1b were determined by ELISA. Healthy groups demonstrated significantly lower levels of IL-1b compared with the inflammation groups. No difference in IL-1b levels was observed between partially edentulous or totally edentulous patients. Salivary IL-1b may be useful for the diagnosis and monitoring of early peri-implant inflammation, particularly in edentulous patients. Key Words: peri-implant sulcular fluid, cytokines, dental implant, inflammation INTRODUCTION O ral rehabilitation with implant-supported prostheses in total and partial edentulous patients is a well-documented procedure.1,2 However, implant failures do occasionally occur. In general, implant loss following successful osseointegration (late failure) is most likely a result of peri-implant disease.3 The development of simple and reliable diagnostic tools for the early detection of peri-implant inflammation and the prevention of irreversible problems is of particular importance.4 Various 1 ˆ ˆ School of Dentistry, Universidade Federal Uberlandia, Uberlandia, Minas Gerais, Brazil. 2 ˆ ˆ School of Dentistry, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil. 3 Department of Immunology, Biomedical Sciences Institute, ˆ ˆ Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil. 4 Department of Oral & Maxillofacial Surgery and Implantology, ˆ ˆ School of Dentistry, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil. * Corresponding author, e-mail: flavianasoares.rocha@gmail.com DOI: 10.1563/AAID-JOI-D-11-00224 clinical and radiographic parameters, such as probing depth, gingival index, plaque accumulation, assessment of bleeding on probing, suppuration, and mobility, are used for this purpose4,5 However, no measure is currently suggested to be sensitive enough to monitor peri-implant conditions at the desired level. Recent research has focused on certain complementary diagnostic tools that are based on saliva compounds.6À8 The analysis of saliva offers an interesting model to evaluate peri-implant status due to its noninvasive nature and the simple method of collection. In addition, saliva is generally readily abundant, compared to sulcular fluid.4 The salivary pro-inflammatory cytokine interleukin-1b (IL-1b) has already been associated with periodontal tissue destruction;9,10 however, no previous study suggests its use as a marker of peri-implant disease. This cytokine is secreted in order to up-regulate inflammatory reactions in concert with other components of the local immune response.11 In this context, the aim of this study was to investigate the potential use of salivary Journal of Oral Implantology 169

Table of Contents for the Digital Edition of Journal of Oral Implantology April 2014

Consolidated Standards of Reporting Trials (CONSORT): Answering the Call for JOI’s Endorsement
Photoelastic Analysis of Stress Distribution With Different Implant Systems
Influence of Abutment Screw Design and Surface Coating on the Bending Flexural Strength of the Implant Set
Comparison of Implant-Abutment Interface Misfits After Casting and Soldering Procedures
Evaluation of Accuracy of Casts of Multiple Internal Connection Implant Prosthesis Obtained From Different Impression Materials and Techniques: An In Vitro Study
The Effect of Different Implant-Abutment Connections on Screw Joint Stability
Effects of pH and Elevated Glucose Levels on the Electrochemical Behavior of Dental Implants
Finite Element Analysis of Provisional Structures of Implant-Supported Complete Prostheses
Saliva Versus Peri-implant Inflammation: Quantification of IL-1b in Partially and Totally Edentulous Patients
Heat Generated During Seating of Dental Implant Fixtures
An Alternative Approach for Augmenting the Anterior Maxilla Using Autogenous Free Gingival Bone Graft for Implant Retained Prosthesis
Nasopalatine Duct Cyst, a Delayed Complication to Successful Dental Implant Placement: Diagnosis and Surgical Management
The Custom Endosteal Implant: Histology and Case Report of a Retrieved Maxillary Custom Osseous-Integrated Implant Nine Years in Service
Occlusal Concepts Application in Resolving Implant Prosthetic Failure: Case Report
Three-Year Follow-Up of a Single Immediate Implant Placed in an Infected Area: A New Approach for Harvesting Autogenous Symphysis Graft
Use of Stress Analysis Methods to Evaluate the Biomechanics of Oral Rehabilitation With Implants

Journal of Oral Implantology April 2014