CCMS Medicine Winter 2017 - 20

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PCSK9 Inhibitors:
To Use or Not to Use?
BY MIAN A. JAN, MD, FACC, FSCAI, AND ZARSHAWN JAN

T

he proprotein, convertase subtilisin/kexin
type 9 (PCSK9) is an enzyme encoded
by the PCSK9 gene in humans on
chromosome 1. Just the name would scare away most
medical students. PCSK9 inhibitors are the next big
thing in medicine. Data has shown that they are very
effective in lowering LDL cholesterol; unfortunately,
their cost is prohibitive. The last time I checked the
cost it was almost $15,000 a year. In this article I
will try to summarize their functions, indications,
effectiveness, and potential side effects.

20 C H E S T E R C O U N T Y M e d i c i n e | W I N T E R 2 0 1 7



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Table of Contents for the Digital Edition of CCMS Medicine Winter 2017

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