Bold Voices - June 2018 - 16

AT THE BEDSIDE

during winter. Seasonal search variapublic hospitaltions in the United States also correlated
ization data from
with those in the United Kingdom and
the Centers for
Australia.
Disease Control and
In the related article, lead study
Prevention, for 2012author Conor Senecal, Mayo Clinic,
2014, specifically
Rochester, Minnesota, says the data
looking for the terms
is anonymous. The research team was
chest pain, angina,
looking at volume in general and didn't
chest discomfort and chest pressure.
know how many people had sympThe search findings were compared to
toms and went to the
patients who were hospiThe frequency of
hospital or were diagtalized for coronary artery
searches for CAD
nosed with CAD.
disease (CAD). Seasonal
However, the
differences in searches were
terms matched the
findings "may have
also assessed for the United
prevalence of cardiac important implications
States, United Kingdom and
hospitalizations of
for search engines as
Australia from 2012-2017.
a resource for patients
The search frequency
U.S. patients.
and potential early
for CAD terms matched the
detection mechanism for providers
prevalence of cardiac hospitalizations
moving forward," the study adds. d
of U.S. patients. For example, searches
increased 50 to 80 percent from 6 to 8
REFERENCE: Senecal C, Widmer RJ, Lerman A. Temporal
and geographic correlation between coronary artery disease
a.m., which coincides with research
prevalence and search engine queries. J Am Coll Cardiol.
2018;71(11)suppl.
that myocardial infarction tends to
be more common in the morning and

Patients' Online
Search Trends
"Googling of Cardiac Symptoms
Tracks With Hospital Admissions for
Coronary Disease," on tctmd.com, notes
that search engines are increasingly
a tool for patients who seek information about symptoms of healthcare
conditions.
"Temporal and Geographic
Correlation Between Coronary Artery
Disease Prevalence and Search Engine
Queries," a supplement in JACC: Journal
of the American College of Cardiology,
was also a poster session at the
college's 2018 Scientific Session, in
Orlando, Florida.
The study sourced U.S. search data
from the Google Trends database and

* University of Oxford review
involves 522 trials
* Data on 116,477 participants
* Concludes all antidepressants
are more effective than placebo

Network Meta-Analysis," in The Lancet,
analyzed 21 drugs in head-to-head
and placebo-controlled trials. Primary
outcomes were efficacy (patients with a
50 percent or more reduction in depressive symptoms) and acceptability
(patients who withdrew from trials for
any reason).

All Antidepressants Beat
Placebo for Acute Major
Depressive Disorder

I

ndividual antidepressants vary in
efficacy and acceptability, but all
are more effective than placebo for
adults with acute major depressive
disorder.
"Comparative Efficacy and
Acceptability of 21 Antidepressant
Drugs for the Acute Treatment
of Adults With Major Depressive
Disorder: A Systematic Review and

16 JUNE 2018 | AACN BOLD VOICES

The review, at the
University of Oxford
in England, involving
522 trials with data
on 116,477 participants, reveals that
all antidepressants are more effective
than placebo. In head-to-head comparisons, agomelatine, amitriptyline,
escitalopram, mirtazapine, paroxetine,
venlafaxine and vortioxetine proved
more effective than other antidepressants. For acceptability, agomelatine,
citalopram and escitalopram, fluoxetine, sertraline and vortioxetine were
more tolerable than others.

The review lists some limitations,
including many trials not reporting
adequate information about randomization and allocation concealment. Also,
the review does not include an analysis
of cost-effectiveness. Still, the findings
"represent the most comprehensive
currently available evidence base to
guide the initial choice about pharmacological treatment for acute major
depressive disorder in adults."
The review notes, "These results should
serve evidence-based practice and
inform patients, physicians, guideline developers, and policy makers
on the relative merits of the different
antidepressants," adding that "future
research should seek to extend network
meta-analysis to combine aggregate and
individual-patient data from trials." d
REFERENCE: Cipriani A, Furukawa TA, Salanti G, et al.
Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major
depressive disorder: a systematic review and network
meta-analysis [published online February 20, 2018]. Lancet.
doi:10.1016/S0140-6736(17)32802-7.


https://www.tctmd.com/news/googling-cardiac-symptoms-tracks-hospital-admissions-coronary-disease https://www.tctmd.com/news/googling-cardiac-symptoms-tracks-hospital-admissions-coronary-disease https://www.tctmd.com/news/googling-cardiac-symptoms-tracks-hospital-admissions-coronary-disease http://www.tctmd.com http://www.onlinejacc.org/content/71/11_Supplement/A98 http://www.onlinejacc.org/content/71/11_Supplement/A98 http://www.onlinejacc.org/content/71/11_Supplement/A98 http://www.onlinejacc.org/content/71/11_Supplement/A98 https://www.sciencedirect.com/science/article/pii/S0140673617328027?via%3Dihub https://www.sciencedirect.com/science/article/pii/S0140673617328027?via%3Dihub https://www.sciencedirect.com/science/article/pii/S0140673617328027?via%3Dihub https://www.sciencedirect.com/science/article/pii/S0140673617328027?via%3Dihub https://www.sciencedirect.com/science/article/pii/S0140673617328027?via%3Dihub https://www.sciencedirect.com/science/article/pii/S0140673617328027?via%3Dihub

Table of Contents for the Digital Edition of Bold Voices - June 2018

Urine
The Power of Possibility
Sepsis: What Nurses Can Do
New Sepsis Bundle From Surviving Sepsis Campaign
Understanding CERPs for Specialty Certification Renewal
In Our Journals
Transitions
America’s ‘Other’ Drug Problem Needs Attention
Effect of Haloperidol on Reducing Mortality
Transitional Care Nurses Can Reduce Admissions of Older Patients
ASHP Developing Standardized Medication Concentrations
Online AACN Course on Care of Older Adults
Hospital Programs Help Employees Cope With Traumatic Events
National Summit on Identification, Prevention and Management of Burnout
Barbershops Help Black Patrons Control Hypertension
Nurse Treats Himself for Myocardial Infarction Using Telehealth
We Have Consensus: TeleICU Continues to Evolve
Cooking Classes Help Patients With CHF
Beware of Chicken Nuggets — and Other Ultra-Processed Foods
Apple Watch Might Randomly Reboot in ICUs
Wound-Monitoring App Helps Reduce Hospital Readmissions
All Antidepressants Beat Placebo for Acute Major Depressive Disorder
Patients’ Online Search Trends
‘Timeout’ Reduces Medication Errors
Possible Link Between High Fitness and Reduced Risk of Dementia
DAISY Award Honors Nurses Who Exemplify Exceptional Compassion and Skill
Interviews With Two Acute Care Nurse Practitioners
Hiring for Cultural Fit
AACN Unveils Updated Online Pharmacology Course
Appreciating the Little Things
Bold Voices - June 2018 - Cover1
Bold Voices - June 2018 - Cover2
Bold Voices - June 2018 - Urine
Bold Voices - June 2018 - The Power of Possibility
Bold Voices - June 2018 - New Sepsis Bundle From Surviving Sepsis Campaign
Bold Voices - June 2018 - Understanding CERPs for Specialty Certification Renewal
Bold Voices - June 2018 - Transitions
Bold Voices - June 2018 - Effect of Haloperidol on Reducing Mortality
Bold Voices - June 2018 - Online AACN Course on Care of Older Adults
Bold Voices - June 2018 - National Summit on Identification, Prevention and Management of Burnout
Bold Voices - June 2018 - Nurse Treats Himself for Myocardial Infarction Using Telehealth
Bold Voices - June 2018 - We Have Consensus: TeleICU Continues to Evolve
Bold Voices - June 2018 - 13
Bold Voices - June 2018 - Beware of Chicken Nuggets — and Other Ultra-Processed Foods
Bold Voices - June 2018 - Wound-Monitoring App Helps Reduce Hospital Readmissions
Bold Voices - June 2018 - Patients’ Online Search Trends
Bold Voices - June 2018 - Possible Link Between High Fitness and Reduced Risk of Dementia
Bold Voices - June 2018 - DAISY Award Honors Nurses Who Exemplify Exceptional Compassion and Skill
Bold Voices - June 2018 - 19
Bold Voices - June 2018 - Hiring for Cultural Fit
Bold Voices - June 2018 - AACN Unveils Updated Online Pharmacology Course
Bold Voices - June 2018 - Appreciating the Little Things
Bold Voices - June 2018 - Cover3
Bold Voices - June 2018 - Cover4
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