Drug Topics - October 22, 2007 - (Page 33)

33 TEST QUESTIONS Write your answers on the answer form appearing on page 34 (photocopies of the answer form are acceptable) or on a separate sheet of paper. Mark the most appropriate answer. 1. Potential etiologies of Parkinson’s disease include all of the following except: a. Genetics b. Drinking well water c. Smoking d. Head trauma 11. Rotigotine can be described as: a. A transdermal dopamine agonist b. A transdermal COMT inhibitor c. A combination COMT inhibitor and carbidopa/ levodopa 2. Which medication can cause parkinsonian-like symptoms? a. Coenzyme Q10 b. Fluoxetine c. Metoclopramide d. Ondansetron d. An extended-release carbidopa/levodopa 12. Which dopamine agonist is associated with pleu- ropulmonary fibrosis? a. Rotigotine b. Apomorphine c. Ropinirole d. Bromocriptine 13. A physician wants to change a patient from 15 mg 3. The motor symptoms experienced by PD patients result from the: a. Loss of acetylcholine neurotransmitters b. Loss of cholinergic neurons c. Loss of dopaminergic neurons d. Loss of serotonergic neurons 4. What is a cardinal symptom of Parkinson’s disease? a. Deliberate tremor c. Hypophonia b. Dementia d. Postural instability 5. Anticholinergic agents are most effective at treat- of bromocriptine to rotigotine. What is an appropriate equivalent dose? a. 2 mg b. 4 mg c. 6 mg d. 8 mg 14. An advantage of COMT inhibitor added to a pa- ing which PD symptom? a. Bradykinesia b. Freezing c. Hypophonia d. Tremor tient’s PD regimen is that it: a. Prolongs the effect of levodopa therapy b. Lessens levodopa’s peripheral side effects c. Decreases the “on” phenomenon d. Increases the rate of absorption of levodopa 15. Tolcapone’s use is limited due to: a. Mitral valve relapse b. Nausea and vomiting c. Sleep attacks d. Hepatotoxicity 16. Carbidopa/levodopa should be considered over a 6. Amantadine may be beneficial in PD patients with: a. Depression and anxiety b. Hypersensitivity to carbidopa/levodopa c. Pronounced akinesia or rigidity d. Tremors 7. A patient with Parkinson’s disease presents with reddish-purple fishnet-pattern mottling of the skin of the upper and lower extremities. This is most likely due to taking: a. Amantadine b. Apomorphine c. Rotigotine d. Tolcapone dopamine agonist for which reason? a. It decreases disease progression b. It improves motor disability c. It lessens motor complications d. It reduces the “on-off” phenomenon 17. A 49-year-old woman is newly diagnosed with 8. What is the advantage of adding carbidopa to levodopa in drug therapy? a. It decreases the frequency of doses. b. It decreases the “on-off” phenomenon. c. It decreases peripheral side effects. d. It increases the rate of absorption. 9. All of the following can reduce adverse reactions PD. She presents with mild symptoms and has received no prior treatment. Which would be the most appropriate initial treatment according to American Academy of Neurology 2002 evidencebased guidelines? a. Apomorphine c. Pramipexole b. Carbidopa/levodopa d. Selegiline 18. According to the AAN, which agent should be the of carbidopa/levodopa except: a. Adding another antiparkinson's agent b. Changing the dosage form c. Dosing less frequently d. Dosing more frequently 10. Pergolide was voluntarily removed from the mar- first option to reduce off time in PD patients with motor fluctuations? a. Amantadine b. Bromocriptine c. Entacapone d. Trihexyphenidyl ket due to: a. Fluid retention b. Hepatotoxicity c. Pulmonary fibrosis d. Valvular dysfunction

Table of Contents Feed for the Digital Edition of Drug Topics - October 22, 2007

Drug Topics - October 22, 2007 Contents Latebreakers Legislative Victory Builds Momentum for Pharmacy Month Letters Health-System Edition R.Ph.s Brace for Payment Denial for Hospital-Acquired Conditions Topical Human Thrombin Helps Arrest Bleeding FDA Panels Fail to Set Target Levels for Renal Patients’ Hemoglobin Warning Letters Raise Patient Safety Concerns for Fentora Ending/Reversing Weight Gain Man Given Fatal Drug Overdose at Staten Island Hospital Pharmacists Playing More Important Role in Dialysis Treatment AHA President R.Ph.'s Here's How You Can Increase Your Value Premier Launches Comprehensive Quality Improvement Project FDA Approves Dexrazoxane for Treatment of Extravasation New Federal, State Reforms to Ease Disaster Relief Kinks 150 Years of American Pharmacy Ten Tips for MTM Success Independent Superstars: The Ones to Watch The New Dynamic Duo A Parkinson's Disease Primer Classified New Products Advertisers Index Viewpoint

Drug Topics - October 22, 2007

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