LCGC The Peak - April 2008 - (Page 7) APRIL 2008 THE PEAK 7 LC LC: Comprehensive Two-Dimensional Liquid Chromatography Peter Schoenmakers, University of Amsterdam To characterize complex samples such as natural products or peptide digests, a single chromatographic dimension cannot completely separate and identify every single compound. For such cases, comprehensive two-dimensional liquid chromatography (LC LC) is under rapid development. Prof. Peter Schoenmakers introduces the topic, and then goes on to talk about peak capacity, sample dimensionality, phase orthogonality, and some of the successes of the technique and the obstacles yet to be overcome. omprehensive two-dimensional separations are a definite trend in chromatography today. Comprehensive two-dimensional gas chromatography (GC GC) emerged some 15 years ago (1). After a sluggish start — arguably attributable to a limited availability of instrumentation and software — this is now a widely accepted and commonly used technique for the separation of complex mixtures of volatile analytes. The C roots of comprehensive two-dimensional liquid chromatography (LC LC ) are older. Two-dimensional thin-layer chromatography can be considered a form of LC LC, dating the technique back at least some 50 years. The contemporary version of LC LC — based upon two columns and an elegant valve-switching concept — was first demonstrated by Erni and Frei (2) and it, too, preceded GC GC by a considerable period of time.
Table of Contents Feed for the Digital Edition of LCGC The Peak - April 2008 LCGC The Peak - April 2008 Contents LC3LC: Comprehensive Two-Dimensional Liquid Chromatography Split Injections in Gas Chromatography: How to Reduce Inlet Discrimination A Simple and Solvent-Free Method for Determining Tetracyclines in Prawns Industry News Events Education LCGC The Peak - April 2008 LCGC The Peak - April 2008 - LCGC The Peak - April 2008 (Page 1) LCGC The Peak - April 2008 - LCGC The Peak - April 2008 (Page 2) LCGC The Peak - April 2008 - LCGC The Peak - April 2008 (Page 3) LCGC The Peak - April 2008 - Contents (Page 4) LCGC The Peak - April 2008 - Contents (Page 5) LCGC The Peak - April 2008 - Contents (Page 6) LCGC The Peak - April 2008 - LC3LC: Comprehensive Two-Dimensional Liquid Chromatography (Page 7) LCGC The Peak - April 2008 - LC3LC: Comprehensive Two-Dimensional Liquid Chromatography (Page 8) LCGC The Peak - April 2008 - LC3LC: Comprehensive Two-Dimensional Liquid Chromatography (Page 9) LCGC The Peak - April 2008 - LC3LC: Comprehensive Two-Dimensional Liquid Chromatography (Page 10) LCGC The Peak - April 2008 - LC3LC: Comprehensive Two-Dimensional Liquid Chromatography (Page 11) LCGC The Peak - April 2008 - LC3LC: Comprehensive Two-Dimensional Liquid Chromatography (Page 12) LCGC The Peak - April 2008 - LC3LC: Comprehensive Two-Dimensional Liquid Chromatography (Page 13) LCGC The Peak - April 2008 - LC3LC: Comprehensive Two-Dimensional Liquid Chromatography (Page 14) LCGC The Peak - April 2008 - LC3LC: Comprehensive Two-Dimensional Liquid Chromatography (Page 15) LCGC The Peak - April 2008 - Split Injections in Gas Chromatography: How to Reduce Inlet Discrimination (Page 16) LCGC The Peak - April 2008 - Split Injections in Gas Chromatography: How to Reduce Inlet Discrimination (Page 17) LCGC The Peak - April 2008 - Split Injections in Gas Chromatography: How to Reduce Inlet Discrimination (Page 18) LCGC The Peak - April 2008 - Split Injections in Gas Chromatography: How to Reduce Inlet Discrimination (Page 19) LCGC The Peak - April 2008 - A Simple and Solvent-Free Method for Determining Tetracyclines in Prawns (Page 20) LCGC The Peak - April 2008 - A Simple and Solvent-Free Method for Determining Tetracyclines in Prawns (Page 21) LCGC The Peak - April 2008 - A Simple and Solvent-Free Method for Determining Tetracyclines in Prawns (Page 22) LCGC The Peak - April 2008 - A Simple and Solvent-Free Method for Determining Tetracyclines in Prawns (Page 23) LCGC The Peak - April 2008 - A Simple and Solvent-Free Method for Determining Tetracyclines in Prawns (Page 24) LCGC The Peak - April 2008 - A Simple and Solvent-Free Method for Determining Tetracyclines in Prawns (Page 25) LCGC The Peak - April 2008 - A Simple and Solvent-Free Method for Determining Tetracyclines in Prawns (Page 26) LCGC The Peak - April 2008 - Industry News (Page 27) LCGC The Peak - April 2008 - Events (Page 28) LCGC The Peak - April 2008 - Events (Page 29) LCGC The Peak - April 2008 - Education (Page 30) LCGC The Peak - April 2008 - Education (Page 31) LCGC The Peak - April 2008 - Education (Page 32)
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