LCGC The Peak - July 2008 - (Page 22) 22 THE PEAK JULY 2008 Figure 2: TIC analysis of trace levels (3 pg on column) of octafluoronapthalene in diesel using high speed chromatography and TOF MS. Run time: 5 min. Original GC–MS data (black) shown overlaid with reprocessed data (blue). Inset shows EIC data (mass 272) for the same analysis. Original data (green) reprocessed data (inverted, blue). reprocessed data (see right hand inset.) Sensitivity: Selective removal of GC–MS background ion contributions reduces the level of noise observed in full scan (TIC) data. In the example shown, the signal to noise ratio (S/N) for the thiophene peak (see red circle) increased from 3:1 (RMS) in the original GC–MS data file to 30:1 in the reprocessed data file, representing a 10-fold increase in sensitivity. Impact on quantitative data: A challenging high speed analysis of diesel fuel spiked with trace levels (3 pg on column) of octafluoronaphthalene was used to investigate potential negative effects of the baseline compensation algorithm on the mass ions contributing to peaks of interest. A time-offlight (TOF) mass spectrometer (BenchTOF-dx from ALMSCO International, Llantrisant, UK) was used in this case. Figure 2 shows the TIC and EIC data from both the original and reprocessed GC–MS data files. While the trace octafluoronaphthalene signal is buried within the diesel matrix in the TIC trace and cannot be detected, its presence and retention time can be confirmed by extracting the key mass 272 ion (see inset to Figure 2). Detailed close comparison of the octafluoronaphthalene extracted ion signal from the original data file and the reprocessed file shows that the peak area data is identical. This indicates that no mass data contributing to this tiny chromatographic peak is lost during the dynamic background compensation process and that full quantitative consistency with the original data has been maintained. Such quantitative consistency cannot be claimed for most conventional static background
Table of Contents Feed for the Digital Edition of LCGC The Peak - July 2008 LCGC The Peak - July 2008 Contents From the Editor Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference Industry News Events Education LCGC The Peak - July 2008 LCGC The Peak - July 2008 - LCGC The Peak - July 2008 (Page Cover1) LCGC The Peak - July 2008 - LCGC The Peak - July 2008 (Page Cover2) LCGC The Peak - July 2008 - LCGC The Peak - July 2008 (Page 3) LCGC The Peak - July 2008 - Contents (Page 4) LCGC The Peak - July 2008 - Contents (Page 5) LCGC The Peak - July 2008 - Contents (Page 6) LCGC The Peak - July 2008 - From the Editor (Page 7) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 8) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 9) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 10) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 11) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 12) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 13) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 14) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 15) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 16) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 17) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 18) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 19) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 20) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 21) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 22) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 23) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 24) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 25) LCGC The Peak - July 2008 - Industry News (Page 26) LCGC The Peak - July 2008 - Events (Page 27) LCGC The Peak - July 2008 - Events (Page 28) LCGC The Peak - July 2008 - Events (Page 29) LCGC The Peak - July 2008 - Education (Page 30) LCGC The Peak - July 2008 - Education (Page 31) LCGC The Peak - July 2008 - Education (Page 32) LCGC The Peak - July 2008 - Education (Page Cover4)
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