LCGC The Peak - July 2008 - (Page 25) JULY 2008 THE PEAK 25 Integration accuracy and run-to-run repeatability: An investigation of the impact could not be implemented and no baseline was drawn. Summary of reprocessing on GC–MS quantification is illustrated in Figure 4. This shows three consecutive high-speed GC-TOF analyses of octafluoronaphthalene-spiked diesel injected manually. Both original and reprocessed data are shown. Visual inspection of the overlaid data from the three reprocessed data files shows excellent run-to-run reproducibility in comparison to the three overlaid original data files. The improved reproducibility of the reprocessed data allowed a sophisticated, time-dependent integration event (applying a “free-hand” baseline between 3.1 and 3.17 min such that peak areas within that window could be summed) to be implemented within a GC–MS data analysis method and applied to all the runs in the data set — see blue oval. The area reproducibility obtained for the three reprocessed files was 4% RSD — remarkable for summed peaks and manual injection. When the same data analysis method (that is, incorporating the integration event) was applied to the original data files for these three runs, it had no effect. In other words, no baseline was constructed on any of the three original GC–MS data files. When a second attempt was made to implement a timed integration event using one of the original GC–MS data files, a baseline was drawn for this one file. However, when this data analysis method was applied subsequently to the other two original data files in the set, y-axis displacement (differences) between the runs meant it This article has illustrated the potential of a new dynamic approach to baseline compensation for improving the quantitative and qualitative performance of GC–MS methods. The enhancements to spectral purity and sensitivity will particularly benefit environmental, forensic, defense, odor, and materials emissions applications requiring detection of trace target compounds or unknowns in complex chromatographic profiles. The flatter baselines and reduced interference also should facilitate more repeatable quantitative data and a higher degree of automation.
Table of Contents Feed for the Digital Edition of LCGC The Peak - July 2008 LCGC The Peak - July 2008 Contents From the Editor Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference Industry News Events Education LCGC The Peak - July 2008 LCGC The Peak - July 2008 - LCGC The Peak - July 2008 (Page Cover1) LCGC The Peak - July 2008 - LCGC The Peak - July 2008 (Page Cover2) LCGC The Peak - July 2008 - LCGC The Peak - July 2008 (Page 3) LCGC The Peak - July 2008 - Contents (Page 4) LCGC The Peak - July 2008 - Contents (Page 5) LCGC The Peak - July 2008 - Contents (Page 6) LCGC The Peak - July 2008 - From the Editor (Page 7) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 8) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 9) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 10) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 11) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 12) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 13) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 14) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 15) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 16) LCGC The Peak - July 2008 - Evaluation of Nonpolar Reversed-Phase Columns Under Supercritical Conditions (Page 17) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 18) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 19) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 20) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 21) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 22) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 23) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 24) LCGC The Peak - July 2008 - Enhancing GC–MS Analysis of Trace Compounds Using a New Dynamic Approach to Reducing Background Interference (Page 25) LCGC The Peak - July 2008 - Industry News (Page 26) LCGC The Peak - July 2008 - Events (Page 27) LCGC The Peak - July 2008 - Events (Page 28) LCGC The Peak - July 2008 - Events (Page 29) LCGC The Peak - July 2008 - Education (Page 30) LCGC The Peak - July 2008 - Education (Page 31) LCGC The Peak - July 2008 - Education (Page 32) LCGC The Peak - July 2008 - Education (Page Cover4)
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