Veterinary Medicine - January 2008 - (Page 49)

tophytes, so is not routinely recommended for those indications. Voriconazole and posaconazole are the newest azoles available in the United States with a primary indication of treating resistant fungal infections. However, their routine use is not recommended because of the limited information available for dogs and cats, their high cost, and the potential for inducing resistance. ACKNOWLEDGMENT I would like to thank Dr. Stuart Snyder for his help with this review. REFERENCES 1. Papich MG, Heit MC, Riviere JE. Antifungal and antiviral drugs. In: Adams HR, ed. Veterinary pharmacology and therapeutics. 8th ed. Ames: Iowa State University Press, 2001;918-946. 2. Hof H. A new, broad-spectrum azole antifungal: posaconazole—mechanisms of action and resistance, spectrum of activity. Mycoses 2006;49(suppl 1):2-6. 3. Consigli J, Danielo C, Gallerano V, et al. Cutaneous leishmaniasis: successful treatment with itraconazole. Int J Dermatol 2006;45(1):46-49. 4. Pagniez F, Abdala-Valencia H, Marchand P, et al. Antileishmanial activities and mechanisms of action of indole-based azoles. J Enzyme Inhib Med Chem 2006;21(3):277-283. 5. Toubiana J, Armengaud JB, Dupouy Camet J, et al. Oral uconazole treatment for extensive cutaneous leishmaniasis in an 11-year-old child. Pediatr Infect Dis J 2006;25(11):1083-1084. 6. Rosales MS, Marsella R, Kunkle G, et al. Comparison of the clinical ef cacy of oral terbina ne and ketoconazole combined with cephalexin in the treatment of Malassezia dermatitis in dogs—a pilot study. Vet Dermatol 2005;16(3):171-176. 7. Baxter JG, Brass C, Schentag JJ, et al. Pharmacokinetics of ketoconazole administered intravenously to dogs and orally as tablet and solution to humans and dogs. J Pharm Sci 1986;75(5):443-447. 8. Lelawongs P, Barone JA, Colaizzi JL, et al. Effect of food and gastric acidity on absorption of orally administered ketoconazole. Clin Pharm 1988;7(3):228-235. 9. Kuroha M, Azumano A, Kuze Y, et al. Effect of multiple dosing of ketoconazole on pharmacokinetics of midazolam, a cytochrome P-450 3A substrate in beagle dogs. Drug Metab Dispos 2002;30(1):63-68. 10. Ward KW, Stelman GJ, Morgan JA, et al. Development of an in vivo preclinical screen model to estimate absorption and rst-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3Alimited bioavailability in the monkey. Drug Metab Dispos 2004;32(2):172-177. 11. Mealey KL. Therapeutic implications of the MDR-1 gene. J Vet Pharmacol Ther 2004;27(5):257-264. 12. Myre SA, Schoeder TJ, Grund VR, et al. Critical ketoconazole dosage range for ciclosporin clearance inhibition in the dog. Pharmacology 1991;43(5):233-241. 13. McAnulty JF, Lensmeyer GL. The effects of ketoconazole on the pharmacokinetics of cyclosporine A in cats. Vet Surg 1999;28(6):448-455. 14. Menegola E, Broccia ML, Di Renzo F, et al. Dysmorphogenic effects of some fungicides derived from the imidazole on rat embryos cultured in vitro. Reprod Toxicol 2006;21(1):74-82. 15. Willard MD, Nachreiner RF, Howard VC, et al. Effect of long-term administration of ketoconazole in cats. Am J Vet Res 1986;47(12):2510-2513. 16. Bennet JE. Antimicrobial agents: antifungal agents. In: Brunton LL, Lazo JS, Parker KL, eds. Goodman & Gilman’s pharmacological basis of therapeutics. 11th ed. New York: McGrawHill, 2005;1225-1241. 17. Berman J. Clinical status of agents being developed for VETERINARY MEDICINE 49 http://www.thecvc.com http://www.thecvc.com

Table of Contents Feed for the Digital Edition of Veterinary Medicine - January 2008

Veterinary Medicine - January 2008 Contents Digital Extra Letters Toxicology Brief Idea Exchange A Challenging Case: Phimosis in a Young Adult Dog The Indications and Technique for Continuous Ambulatory Electrocardiographic Recording in Dogs A Review of Selected Systemic Antifungal Drugs for Use in Dogs and Cats CE Form Advertiser Index Marketplace/Classifieds Mind Over Miller

Veterinary Medicine - January 2008

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