Veterinary Medicine - February 2008 - (Page 98) Managing feline kidney transplant patients PEER-REVIEWED protocols include combination therapy using microemulsi ed cyclosporine and prednisone.16 Some transplant institutions recommend administering cyclo- ng/ml for life.16,38 Immunosuppressive prednisolone therapy is also initiated just before surgery at 0.25 mg/kg given orally every 12 hours, adjusting to once Some institutions recommend administering cyclosporine for two weeks before surgery. sporine for two weeks before surgery to ensure adequate serum trough levels at the time of surgery, thus preventing initiation of a host vs. graft immune response. Cyclosporine is usually administered at 3 to 5 mg/kg given orally every 12 to 24 hours to obtain whole blood trough concentrations of 500 ng/ ml for the rst month, then 150 to 250 drug interaction has been demonstrated in cats.40 The bene t is the possibility of once-daily dosing and a lower cost. The disadvantages are the additional pilling requirements and ketoconazoleassociated hepatotoxicosis. Comparison studies are still lacking to provide a substantial advantage over the current protocols used. TRANSPLANT PROCEDURE OVERVIEW Anesthesia and preoperative management daily after 30 days.16,38 Multiple agents have been known to alter cyclosporine metabolism by increasing the blood cyclosporine concentration and reducing cyclosporine elimination. A regimen using ketoconazole with cyclosporine allows a signi cant reduction in the cyclosporine dose in people after kidney transplantation.39 The same Anesthesia of patients with end-stage kidney disease is challenging because of altered renal physiology and pharmacokinetics. Chronic kidney disease affects the hematopoietic, cardiovascular, neurologic, metabolic, endocrine, gastrointestinal, pulmonary, and immunologic systems in individual and interrelated ways. Many characteristic metabolic http://www.petkingbrands.com http://www.petkingbrands.com
For optimal viewing of this digital publication, please enable JavaScript and then refresh the page. If you would like to try to load the digital publication without using Flash Player detection, please click here.