Veterinary Medicine - March 2008 - (Page Virbac2) Glycotechnology Like all cells, the keratinocytes of the epidermis have glycoproteins that are essential in cell-to-cell communication. However, these glycoproteins also serve as magnets to external pathogens (i.e., Staphylococcus, Pseudomonas) through lectin binding. Microbial lectins are virulence factors located on the surface of the pathogen. Once these pathogens attach their microbial lectins to the skin glycoproteins, they can colonize and cause infection. Attached pathogens can also activate keratinocytes to produce cytokines, such as TNF- , which cause inflammation. Glycotechnology works by applying exogenous sugars (D- mannose, D-galactose, L-rhamnose, Alkylpolyglucoside) that mimic the skin sugars in glycoproteins. These exogenous sugars produce an anti-adhesive effect between the skin sugars and pathogens. Because these exogenous sugars mimic and bind to the skin sugars, they attract and have initial contact with the pathogens’ lectins. This initial contact causes the lectin binding sites to become saturated with exogenous sugars—not skin sugars— and, therefore, helps prevent infection and, thus, inflammation. An added benefit Traditional methods of managing skin conditions include the administration of antibiotics, Spherulite technology Spherulites are microspheres composed of concentric layers that continually release ingredients to protect the skin. Spherulites, depending on their ionic charge, either bind to the skin, such as with glycotechnology, or penetrate the skin, helping to prevent irritants from triggering the immune system. Figure 1. Anti-adhesive action Microbial lectins —Host sugars interactions Microorganisms Bacterial lectins Lectin blockage by exogenous sugars External environment Host sugar receptor Host skin surface Corneocyte surface Exogenous sugars Host sugar receptor Host skin surface Exogenous sugars saturate the lectin binding sites so microorganisms cannot adhere to the skin sugars and cause infection, which leads to inflammation.
Table of Contents Feed for the Digital Edition of Veterinary Medicine - March 2008 Veterinary Medicine - March 2008 Contents Toxicology Brief Idea Exchange A Challenging Case An Update on Diagnosing and Treating Primary Lung Tumors CE Form Product Preview Advertiser Index Marketplace/Classifieds Mind Over Miller Veterinary Medicine - March 2008 Veterinary Medicine - March 2008 - Veterinary Medicine - March 2008 (Page Cover1) Veterinary Medicine - March 2008 - Veterinary Medicine - March 2008 (Page Cover2) Veterinary Medicine - March 2008 - Contents (Page 131) Veterinary Medicine - March 2008 - Contents (Page 132) Veterinary Medicine - March 2008 - Contents (Page 133) Veterinary Medicine - March 2008 - Contents (Page 134) Veterinary Medicine - March 2008 - Contents (Page 135) Veterinary Medicine - March 2008 - Contents (Page 136) Veterinary Medicine - March 2008 - Contents (Page 137) Veterinary Medicine - March 2008 - Toxicology Brief (Page 138) Veterinary Medicine - March 2008 - Toxicology Brief (Page 139) Veterinary Medicine - March 2008 - Toxicology Brief (Page 140) Veterinary Medicine - March 2008 - Toxicology Brief (Page 141) Veterinary Medicine - March 2008 - Toxicology Brief (Page 142) Veterinary Medicine - March 2008 - Toxicology Brief (Page 143) Veterinary Medicine - March 2008 - Idea Exchange (Page 144) Veterinary Medicine - March 2008 - Idea Exchange (Page 145) Veterinary Medicine - March 2008 - A Challenging Case (Page 146) Veterinary Medicine - March 2008 - A Challenging Case (Page Bayer1) Veterinary Medicine - March 2008 - A Challenging Case (Page Bayer2) Veterinary Medicine - March 2008 - A Challenging Case (Page Bayer3) Veterinary Medicine - March 2008 - A Challenging Case (Page Bayer4) Veterinary Medicine - March 2008 - A Challenging Case (Page 147) Veterinary Medicine - March 2008 - A Challenging Case (Page 148) Veterinary Medicine - March 2008 - A Challenging Case (Page 149) Veterinary Medicine - March 2008 - A Challenging Case (Page 150) Veterinary Medicine - March 2008 - A Challenging Case (Page 151) Veterinary Medicine - March 2008 - A Challenging Case (Page 152) Veterinary Medicine - March 2008 - A Challenging Case (Page 153) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 154) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 155) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 156) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 157) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 158) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 159) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 160) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 161) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 162) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page Virbac1) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page Virbac2) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page Virbac3) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page Virbac4) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 163) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 164) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 165) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 166) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 167) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 168) Veterinary Medicine - March 2008 - An Update on Diagnosing and Treating Primary Lung Tumors (Page 169) Veterinary Medicine - March 2008 - CE Form (Page 170) Veterinary Medicine - March 2008 - Product Preview (Page 171) Veterinary Medicine - March 2008 - Advertiser Index (Page 172) Veterinary Medicine - March 2008 - Marketplace/Classifieds (Page 173) Veterinary Medicine - March 2008 - Marketplace/Classifieds (Page 174) Veterinary Medicine - March 2008 - Marketplace/Classifieds (Page 175) Veterinary Medicine - March 2008 - Marketplace/Classifieds (Page 176) Veterinary Medicine - March 2008 - Marketplace/Classifieds (Page 177) Veterinary Medicine - March 2008 - Mind Over Miller (Page 178) Veterinary Medicine - March 2008 - Mind Over Miller (Page Cover3) Veterinary Medicine - March 2008 - Mind Over Miller (Page Cover4)
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