Veterinary Medicine - July 2008 - (Page V8)

S-adenosylmethionine (SAMe) and cognitive dysfunction in dogs di erence in the quality of brands of SAMe, as there is in some of the other herbal products? Mischoulon: I am asked that a lot. A lot of the early oral forms of SAMe were quite unstable and lost their efficacy quickly. That affected a lot of the early SAMe trials. The new tosylated forms on the market are much more stable and have a long half-life. As far as SAMe goes, I would be confident in the brands that come from reputable organizations. I tell patients to shop around but go to health food and drug stores that are reputable. Be careful about shopping on the Internet and buying an unknown brand, especially one that makes outlandish claims. A lot of them may be very poor quality preparations. It’s the same principle when buying medicine for pets. Landsberg: Nutraceutical products are not as regulated as pharmaceuticals, so make sure that the product is from a reputable manufacturer. Does the packaging matter? Is there a problem with loose pills in a bottle versus individual blister wrap packaging? loose tablets. Is that correct? Bottiglieri: Yes. That is how some of the early SAMe tablets were sold, and it was a problem. In the year 2000, we tested some SAMe tablets in the lab and found out that some of them contained 0% SAMe. Landsberg: Knowing what you have learned today, as a practitioner, how would you use Novi t in treating your cognitive patients, once it becomes available in the United States. Florsheim: I would consider recommending it for older patients in general. Because of its neuroprotective e ect, I would discuss its use with clients during every senior exam while we’re discussing the changes that are going to occur in the pet. It could be a good supplement for dogs that are showing signs of early cognitive decline and dogs showing no signs yet. I also think it is a rst line of intervention for patients showing the more extreme signs. Landsberg: Trying a supplement that has virtually no side e ects and then considering other drugs as either an 2. Landsberg G, Araujo, JA. Geriatric behavior problems. Vet Clin North Am Small Anim Pract 2005;35:675-698. 3. Anipryl [product insert]. New York, N.Y.: P zer Animal Health, 2000. 4. Milgram NW, Head EA, Zicker SC et al. Long term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Exp Gerontol 2004;39:753-765. 5. Araujo JA, Studzinski, CM, Milgram NW. Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:411-422. 6. Villanueva JA, Esfandiari F, White ME, et al. S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-de cient diet. Alcohol Clin Exp Res 2007;31:1934-1943. 7. Terneus MV, Kiningham KK, Carpenter AB, et al. Comparison of S-Adenosyl-Lmethionine and N-acetylcysteine protective effects on acetaminophen hepatic toxicity. J Pharmacol Exp Ther 2007;320:99-107. 8. Villalobos MA, De La Cruz JP, Cuerda MA, et al. Effect of S-adenosyl-Lmethionine on rat brain oxidative stress damage in a combined model of permanent focal ischemia and global ischemiareperfusion. Brain Res 2000;883:31-40. 9. Stramentinoli G, Gualano M, Catto E, et al. Tissue levels of S-adenosylmethionine in aging rats. J Gerontol 1977;32:392-394. 10. Surtees R, Hyland K. Cerebrospinal uid concentrations of Sadenosylmethionine, methionine, and 5-methyltetrahydrofolate in a reference population: cerebrospinal uid Sadenosylmethionine declines with age in humans. Biochem Med Metab Biol 1990;44:192-199. 11. Bottiglieri T, Reynolds EH, Laundy M. Folate in CSF and age. J Neurol Neurosurg Psychiatry 2000;69:562. 12. Refsum H, Nurk E, Smith AD, et al. The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr 2006;136(suppl 6): 1731S-1740S. 13. Réme CA, Dramard V, Kern L, et al. Effects of S-adenosylmethionine tablets on the reduction of age-related mental decline in dogs: a double-blinded placebocontrolled trial. Vet Ther 2008;9:69-82. “Management of dementia is dependent on early detection and intervention.” - Dr. Teodoro Bottiglieri Bottiglieri: To ensure long-term stability, the SAMe tablets should be stored in a sealed foil strip. If the tablet is exposed to moisture it will degrade and oxidize within months. Landsberg: In other words, you would avoid bottles that are packaged as alternative or adjunct therapy later would be the safest and most logical route to take. References 1. Neilson JC, Hart BL, Cliff KD, et al. Prevalence of behavioral changes associated with age-related cognitive impairment in dogs. J Am Vet Med Assoc 2001;218:1787-1791. © 2008 Virbac Animal Health. To view this publication online, visit www.advanstarvhc.com/c43. VF607 8 http://www.advanstarvhc.com/c43

Table of Contents Feed for the Digital Edition of Veterinary Medicine - July 2008

Veterinary Medicine - July 2008 Contents Leading Off Practical Matters Idea Exchange Clarification Dental Corner The Diagnostic Approach to Hematuria Guidelines for Evaluating Hypercalcemic Cats CE Form Advertiser Index Marketplace/Classifieds Mind Over Miller

Veterinary Medicine - July 2008

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