Veterinary Medicine - September 2007 - (Page 597) Because of these potential side effects in dogs and cats and the lack of convincing efficacy in lowering triglyceride concentration, we rarely use statins to treat hypertriglyceridemia. Hypercholesterolemia Treatment of hypercholesterolemia relies largely on diet and occasionally on pharmacologic intervention. As mentioned previously, dogs and cats transport most of their cholesterol as HDLs, minimizing the risk of atherosclerosis. Thus, we do not recommend treating hypercholesterolemia until the concentration is above 750 mg/dl in dogs or 650 mg/dl in cats because of the likely increase in LDL that may predispose them to atherosclerosis at these concentrations. 9 As with hypertriglyceridemia, the search for secondary causes is a must. In our experience, severe hypercholesterolemia in cats is rarely encountered and in dogs is usually secondary to hypothyroidism. Dietary modification. For severe idiopathic hypercholesterolemia, lowfat diets are the mainstay of therapy.3 In addition, soluble fiber (gums, pectins) can be added to diets to help decrease the cholesterol concentration.19 Soluble fiber interferes with the enteric absorption of bile acids and increases the hepatic use of cholesterol to synthesize bile acids.20 Pharmacologic intervention. For those patients unresponsive to diet alone, bile acid sequestrates and statins may be considered. Bile acids are synthesized in the liver from cholesterol and excreted into the duodenum. Cholestyramine (Questran—Bristol-Myers Squibb) is an ion exchange resin that interferes with the enteric absorption of bile acids and is approved for use in people to lower cholesterol.18 Cholestyramine (1 to 2 g orally b.i.d.) results in increased cholesterol use for bile acid synthesis. 3,18 As hepatic cholesterol concentration decreases, hepatic LDL http://www.prnpharmacal.com http://www.prnpharmacal.com
Table of Contents Feed for the Digital Edition of Veterinary Medicine - September 2007 Contents Letters Leading Off The Veterinary Medicine Interview: Dr. William J. Kay Idea Exchange Practical Matters Salivary Mucoceles in Cates: A Retropspective Study of Seven Cases Hyperlipidemia in Dogs and Cats Purina Insert The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus CE Form Product Preview Advertiser Index Marketplace/Classifieds Mind Over Miller Veterinary Medicine - September 2007 Veterinary Medicine - September 2007 - (Page Cover1) Veterinary Medicine - September 2007 - (Page Cover2) Veterinary Medicine - September 2007 - (Page 563) Veterinary Medicine - September 2007 - (Page 564) Veterinary Medicine - September 2007 - Contents (Page 565) Veterinary Medicine - September 2007 - Contents (Page 566) Veterinary Medicine - September 2007 - Contents (Page 567) Veterinary Medicine - September 2007 - Contents (Page 568) Veterinary Medicine - September 2007 - Contents (Page 569) Veterinary Medicine - September 2007 - Letters (Page 570) Veterinary Medicine - September 2007 - Letters (Page 571) Veterinary Medicine - September 2007 - Leading Off (Page 572) Veterinary Medicine - September 2007 - Leading Off (Page 573) Veterinary Medicine - September 2007 - The Veterinary Medicine Interview: Dr. William J. Kay (Page 574) Veterinary Medicine - September 2007 - The Veterinary Medicine Interview: Dr. William J. Kay (Page 575) Veterinary Medicine - September 2007 - Idea Exchange (Page 576) Veterinary Medicine - September 2007 - Idea Exchange (Page 577) Veterinary Medicine - September 2007 - Idea Exchange (Page 578) Veterinary Medicine - September 2007 - Idea Exchange (Page 579) Veterinary Medicine - September 2007 - Practical Matters (Page 580) Veterinary Medicine - September 2007 - Practical Matters (Page 581) Veterinary Medicine - September 2007 - Salivary Mucoceles in Cates: A Retropspective Study of Seven Cases (Page 582) Veterinary Medicine - September 2007 - Salivary Mucoceles in Cates: A Retropspective Study of Seven Cases (Page 583) Veterinary Medicine - September 2007 - Salivary Mucoceles in Cates: A Retropspective Study of Seven Cases (Page 584) Veterinary Medicine - September 2007 - Salivary Mucoceles in Cates: A Retropspective Study of Seven Cases (Page 585) Veterinary Medicine - September 2007 - Salivary Mucoceles in Cates: A Retropspective Study of Seven Cases (Page 586) Veterinary Medicine - September 2007 - Salivary Mucoceles in Cates: A Retropspective Study of Seven Cases (Page 587) Veterinary Medicine - September 2007 - Hyperlipidemia in Dogs and Cats (Page 588) Veterinary Medicine - September 2007 - Hyperlipidemia in Dogs and Cats (Page 589) Veterinary Medicine - September 2007 - Hyperlipidemia in Dogs and Cats (Page 590) Veterinary Medicine - September 2007 - Hyperlipidemia in Dogs and Cats (Page 591) Veterinary Medicine - September 2007 - Hyperlipidemia in Dogs and Cats (Page 592) Veterinary Medicine - September 2007 - Hyperlipidemia in Dogs and Cats (Page 593) Veterinary Medicine - September 2007 - Hyperlipidemia in Dogs and Cats (Page 594) Veterinary Medicine - September 2007 - Purina Insert (Page S1) Veterinary Medicine - September 2007 - Purina Insert (Page S2) Veterinary Medicine - September 2007 - Purina Insert (Page S3) Veterinary Medicine - September 2007 - Purina Insert (Page S4) Veterinary Medicine - September 2007 - Purina Insert (Page S5) Veterinary Medicine - September 2007 - Purina Insert (Page S6) Veterinary Medicine - September 2007 - Purina Insert (Page S7) Veterinary Medicine - September 2007 - Purina Insert (Page S8) Veterinary Medicine - September 2007 - Purina Insert (Page 595) Veterinary Medicine - September 2007 - Purina Insert (Page 596) Veterinary Medicine - September 2007 - Purina Insert (Page 597) Veterinary Medicine - September 2007 - Purina Insert (Page 598) Veterinary Medicine - September 2007 - Purina Insert (Page 599) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 600) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 601) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 602) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 603) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 604) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 605) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 606) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 607) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 608) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 609) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 610) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 611) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 612) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 613) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 614) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 615) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 616) Veterinary Medicine - September 2007 - The Latest Management Recommendations for Cats and Dogs with Nonketotic Diabetes Mellitus (Page 617) Veterinary Medicine - September 2007 - CE Form (Page 618) Veterinary Medicine - September 2007 - Product Preview (Page 619) Veterinary Medicine - September 2007 - Advertiser Index (Page 620) Veterinary Medicine - September 2007 - Marketplace/Classifieds (Page 621) Veterinary Medicine - September 2007 - Marketplace/Classifieds (Page 622) Veterinary Medicine - September 2007 - Marketplace/Classifieds (Page 623) Veterinary Medicine - September 2007 - Marketplace/Classifieds (Page 624) Veterinary Medicine - September 2007 - Marketplace/Classifieds (Page 625) Veterinary Medicine - September 2007 - Mind Over Miller (Page 626) Veterinary Medicine - September 2007 - Mind Over Miller (Page Cover3) Veterinary Medicine - September 2007 - Mind Over Miller (Page Cover4)
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