Veterinary Medicine - November 2007 - (Page 736) OPEER-REVIEWED Pimobendan treatment in dogs with congestive heart failure When used in conjunction with other cardiac drugs, pimobendan may benefit dogs with congestive heart failure secondary to dilated cardiomyopathy or degenerative valve disease. Justin D. Thomason, DVM, DACVIM (small animal internal medicine); Tiffany K. Fallaw, BS, RVT; and Clay Calvert, DVM, DACVIM (small animal internal medicine) Editors’ note: This article is an updated excerpt from “Pimobendan: Understanding its cardiac effects in dogs with myocardial disease,” which appeared in Veterinary Medicine’s October 2006 issue. P imobendan, a benzimidazole-pyridazinone drug, is classified as an inodilator because of its nonsympathomimetic, nonglycoside positive inotropic (through myocardial calcium sensitization) and vasodilator properties.1-4 As such, pimobendan increases ventricular contractility and reduces preload and afterload in patients with advanced cardiac insufficiency. Pimobendan (Vetmedin—Boehringer Ingelheim Vetmedica) is now approved in the United States for use in dogs to manage signs of mild, moderate, or severe congestive heart failure originating from atrioventricular valvular insufficiency or dilated cardiomyopathy. To understand the pharmacology and therapeutic potential of pimobendan, clinicians should be familiar with the mechanisms of cardiac muscle contraction in healthy and diseased hearts. MYOCARDIAL CONTRACTION Myocardial contraction (i.e. excitation-contraction coupling) begins when a depolarization wave reaches a myocyte.2 In excitation-contraction coupling, action potentials depolarize cardiac muscle cell membranes, with phase 2 of the action Justin D. Thomason, DVM, DACVIM (small animal internal medicine) Department of Clinical Sciences Center for Veterinary Health Sciences Oklahoma State University Stillwater, OK 74078 Tiffany K. Fallaw, BS, RVT Clay Calvert, DVM, DACVIM (small animal internal medicine) Department of Small Animal Medicine and Surgery College of Veterinary Medicine University of Georgia Athens, GA 30605 736 November 2007 VETERINARY MEDICINE Illustration by Paul Petersen
Table of Contents Feed for the Digital Edition of Veterinary Medicine - November 2007 Veterinary Medicine - November 2007 Contents Leading Off The Veterinary Medicine Interview: Dr. Lila Miller Clinical Exposures Idea Exchange A Challenging Case: Uveitis and Secondary Glaucoma in a Cat Is it Immune-Mediated Neutropenia? Pimobendan Treatment in Dogs with Congestive Heart Failure CE Form Product Preview Advertiser Index Marketplace/Classifieds Mind Over Miller Special Supplement by Lilly: Flea Bite Facts Q&A Veterinary Medicine - November 2007 Veterinary Medicine - November 2007 - Veterinary Medicine - November 2007 (Page Cover1) Veterinary Medicine - November 2007 - Veterinary Medicine - November 2007 (Page Cover2) Veterinary Medicine - November 2007 - Contents (Page 699) Veterinary Medicine - November 2007 - Contents (Page 700) Veterinary Medicine - November 2007 - Contents (Page 701) Veterinary Medicine - November 2007 - Contents (Page 702) Veterinary Medicine - November 2007 - Contents (Page 703) Veterinary Medicine - November 2007 - Leading Off (Page 704) Veterinary Medicine - November 2007 - Leading Off (Page 705) Veterinary Medicine - November 2007 - The Veterinary Medicine Interview: Dr. Lila Miller (Page 706) Veterinary Medicine - November 2007 - The Veterinary Medicine Interview: Dr. Lila Miller (Page 707) Veterinary Medicine - November 2007 - Clinical Exposures (Page 708) Veterinary Medicine - November 2007 - Clinical Exposures (Page 709) Veterinary Medicine - November 2007 - Clinical Exposures (Page 710) Veterinary Medicine - November 2007 - Clinical Exposures (Page 711) Veterinary Medicine - November 2007 - Idea Exchange (Page 712) Veterinary Medicine - November 2007 - Idea Exchange (Page 713) Veterinary Medicine - November 2007 - A Challenging Case: Uveitis and Secondary Glaucoma in a Cat (Page 714) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L1) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L2) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L3) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L4) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L5) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L6) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L7) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L8) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L9) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L10) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L11) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L12) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L13) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L14) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L15) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page L16) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page 715) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page 716) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page 717) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page 718) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page 719) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page 720) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page 721) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page 722) Veterinary Medicine - November 2007 - Special Supplement by Lilly: Flea Bite Facts Q&A (Page 723) Veterinary Medicine - November 2007 - Is it Immune-Mediated Neutropenia? (Page 724) Veterinary Medicine - November 2007 - Is it Immune-Mediated Neutropenia? (Page 725) Veterinary Medicine - November 2007 - Is it Immune-Mediated Neutropenia? (Page 726) Veterinary Medicine - November 2007 - Is it Immune-Mediated Neutropenia? (Page 727) Veterinary Medicine - November 2007 - Is it Immune-Mediated Neutropenia? (Page 728) Veterinary Medicine - November 2007 - Is it Immune-Mediated Neutropenia? (Page 729) Veterinary Medicine - November 2007 - Is it Immune-Mediated Neutropenia? (Page 730) Veterinary Medicine - November 2007 - Is it Immune-Mediated Neutropenia? (Page 731) Veterinary Medicine - November 2007 - Is it Immune-Mediated Neutropenia? (Page 732) Veterinary Medicine - November 2007 - Is it Immune-Mediated Neutropenia? (Page 733) Veterinary Medicine - November 2007 - Is it Immune-Mediated Neutropenia? (Page 734) Veterinary Medicine - November 2007 - Is it Immune-Mediated Neutropenia? (Page 735) Veterinary Medicine - November 2007 - Pimobendan Treatment in Dogs with Congestive Heart Failure (Page 736) Veterinary Medicine - November 2007 - Pimobendan Treatment in Dogs with Congestive Heart Failure (Page 737) Veterinary Medicine - November 2007 - Pimobendan Treatment in Dogs with Congestive Heart Failure (Page 738) Veterinary Medicine - November 2007 - Pimobendan Treatment in Dogs with Congestive Heart Failure (Page 739) Veterinary Medicine - November 2007 - Pimobendan Treatment in Dogs with Congestive Heart Failure (Page 740) Veterinary Medicine - November 2007 - Pimobendan Treatment in Dogs with Congestive Heart Failure (Page 741) Veterinary Medicine - November 2007 - CE Form (Page 742) Veterinary Medicine - November 2007 - Product Preview (Page 743) Veterinary Medicine - November 2007 - Advertiser Index (Page 744) Veterinary Medicine - November 2007 - Marketplace/Classifieds (Page 745) Veterinary Medicine - November 2007 - Marketplace/Classifieds (Page 746) Veterinary Medicine - November 2007 - Marketplace/Classifieds (Page 747) Veterinary Medicine - November 2007 - Marketplace/Classifieds (Page 748) Veterinary Medicine - November 2007 - Marketplace/Classifieds (Page 749) Veterinary Medicine - November 2007 - Mind Over Miller (Page 750) Veterinary Medicine - November 2007 - Mind Over Miller (Page Cover3) Veterinary Medicine - November 2007 - Mind Over Miller (Page Cover4)
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