The Column February 2006 - (Page 8)

Opinion The Column www.thecolumn.eu.com February 2006 The Silica Maze Zosimus wonders why there is so much silica to choose from? EuroSilica. I remember being in one of the most fascinating, Does anyone else find it difficult to decide what type of silica to interesting and heated debates I have ever attended at any use? When we purchased our new column, yes, we knew we chromatography conference. The debate was over the need for a wanted a C18 bonding, but which particular one? It's even more standard EuroSilica. It was a very polarized debate with the problematic deciding what silica to choose? An Internet search existing silica manufacturers saying we do not need a new revealed just under 100 different silica brands as shown in Table 1. standard as we do need a wide choice of silicas to obtain the This is not meant to be a fully inclusive list and I apologize to any selectivity that industry requires. Conversely, the academics silica manufacturer whose brand I have missed, but if I have then argued that there was a real need for a standard. I can maybe you should get a better search engine listing! remember coming away from that debate on the side of the Are all these silicas unique or are a lot of them just the same manufacturers. I think this was more on the agreements on who silica under a different brand name? More importantly, what is would make the silica and how reproducible it could be made. the real difference between these silicas? First of all let me If the same debate was to be held at another HPLC address the issue of why there are so many. In any market where conference, then I would be in favour of a new standard silica. there are very high profits you will find many product brands. In 2003, Sander and Wise published their work on a new This is why the silica market can support so many different or reference material for column evaluation in reversed phase.1 similar brands. Do we need so many brands? Of course not! In the early 90s, there was a move to manufacture a standard But back to our problem on the choice we have today. There Author: Zosimus E-mail: zosimus@thecolumn.eu.com 8 http://www.thecolumn.eu.com

Table of Contents for the Digital Edition of The Column February 2006

News
Opinion
Market Trends & Analysis
A New System for High-Temperature Gradient HPLC of Polymers
Selective Extractions by Molecularly Imprinted Polymers (MIPs)
Country Focus
Q&A
Supplement: Acquity UPLC™ System - Application Notebook

The Column February 2006

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