The Column - April 2009 - (Page 20)

Market Trends and Analysis The Column www.thecolumn.eu.com April 2009 Market Profile: Automated Peptide/Protein Sequencers sequencing. Mass spectrometry, particularly tandem Edman degradation is a process of protein sequencing first time-of-flight (TOF-TOF and QTOF) instruments, allows the discovered by a Swedish biochemist Pehr Victor Edman in task to be performed faster with low quantities of samples. 1950. The technique is often characterized in cycles. For a The obvious advantage of automated Edman degradation full cycle to occur, Phenylisothiocyanate labels N-terminus over mass spectrometry includes accuracy of the given peptide, forms a cyclical from proven chemistry and compound, then under 2007 Protein Sequencer Demand by Lab Function a significantly lower initial acidic conditions the labelled system cost. However, its amino acid is cleaved away drawbacks include longer analysis from the peptide and treated R&D times and limited number of further in acid to form a more 43% sequences, typically ranging stable phenylthiohydantoin from 20 to 50 amino (PTH)-amino acid (AA) acids. Conversely, mass derivative. The PTH-AA Other spectrometry is ideal if derivative is then 7% the peptide quantity identified by using is in low abundance, HPLC. This Edman the N-terminal is degradation cycle Quality control inaccessible and/or is performed 12% if a time of analysis repeatedly to is an issue. However, the sequential this technique comes amino acids of the with a heftier price shortened peptide tag and has trouble to identify the Analytical services distinguishing isobaric remaining sequence. 38% amino acids. In 1982, Applied Applied Biosystems Biosystems introduced (ABI) dominated the the first commercial automated peptide automated peptide sequencer market but sequencer, which proved to be discontinued manufacturing its reliable and robust. In fact, with automated peptide sequencer product line only a handful of enhancements over in June 2008 as the market for systems softened. the decades, these automated peptide sequencers Shimadzu, however, seeing the opportunity, introduced continues to be the gold standard for such applications. its PPSQ automated peptide sequencer in North America However, the use of tandem mass spectrometry has at Pittcon 2009. The PPSQ has been widely used in become an increasingly important tool for peptide Contact author: E-mail: Glenn Cudiamat cudiamat@strategic-directions.com 20 http://www.thecolumn.eu.com

Table of Contents for the Digital Edition of The Column - April 2009

The Column - April 2009
Contents
HPTLC Determination of Polycyclic Aromatic Hydrocarbons in Mussels After a Crude Oil Spill in Chile
News
Incognito - Pittcon Pioneers…
Market Trends & Analysis
Characterizing the Secreted Proteome of Mycobacterium Tuberculosis by LC–MS–MS
Tips and Tricks: GPC/SEC
Meeting Review - Pittcon 2009
Q&A

The Column - April 2009

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