The Column - October 2008 - (Page 25)
October 2008 www.thecolumn.eu.com The Column Dunsbach and Ketterlinus Bringing Together GC and LC on an MS-TOF System Ralf Dunsbach and Ralf Ketterlinus, Bruker Daltonik GmbH, Bremen, Germany. This article describes the coupling of gas chromatography and liquid chromatography with a high-resolution time-of-flight mass spectrometer using a specifically designed atmospheric pressure chemical ionization (APCI) interface to provide increased flexibility and performance. Changing Between GC and LC in Minutes Laboratories that occasionally need a GC-TOF-MS for resolving complex mixtures or for the identification of unknown peaks, for example, in a gas chromatography (GC) chromatogram are able to perform both LC and GC separations without requiring a dedicated GC-TOF-MS. Bruker Daltonics’ micrOTOF II with APCI interface (Figure 1) reportedly makes the need for such an instrument obsolete. Its GC–LC–MS system can be up and running within minutes; giving full access to the features of a high resolution TOF mass spectrometer, such as accurate mass, high resolution extracted ion chromatograms (hrEIC) and sophisticated formula determination capabilities. by the chromatographic system used for separation and thus delivers the full analytical capabilities of an LC–MS to the GC–MS world. Ionization: APCI and APLI The APCI allows switching from GC to LC and vice versa in a few minutes. It consists of a heated transfer line for GC Figure 1: Coupling GC-TOF-MS using a micrOTOF II, APCI interface and Agilent 7890 GC. A Wide Range of Analytes TOF mass spectrometers have been widely used in combination with liquid chromatography. These systems can demonstrate a mass resolution of 16500 FWHM and a mass accuracy of more than 2 ppm. TOF systems that are designed to work with gas chromatography usually provide only a reduced performance. Until now, a solution that uses the same TOF-MS on both GC and LC systems, merely by exchanging the chromatographic system, has not existed. However, the company’s APCI source allows a micrOTOF, which is basically an LC–TOF-MS, to be coupled with a gas chromatograph. The high performance of the micrOTOF II, in terms of mass resolution and mass accuracy, is not influenced Author: Ralf Ketterlinus E-mail: rak@bdal.de UpperCut Images/Getty Images 25
http://www.thecolumn.eu.com
Table of Contents for the Digital Edition of The Column - October 2008
The Column - October 2008
Contents
Rapid Fatty Acid Fingerprinting in Microalgae by Gas Chromatography: Analytical Opportunities
News
Incognito: Total Solutions — Really?
Market Trends and Analysis: Market Profile: The Analytical and Life Science Instruments Industry
Tips and Tricks: GPC/SEC: Understanding Positive and Negative Detector Signals
Biodiesel Patterns Reflect Quality: Analysis According to DIN EN 14103
Bringing Together GC and LC on an MS–TOF System
Q&A
The Column - October 2008
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