The Column - December 2006 - (Page 20)

Warning : session_start : The session id contains invalid characters, valid characters are only a-z, A-Z and 0-9 in /mnt/data/www.nxtbook.com/fx/config_1.3/global.php on line 9 Warning : session_start : Cannot send session cache limiter - headers already sent output started at /mnt/data/www.nxtbook.com/fx/config_1.3/global.php:9 in /mnt/data/www.nxtbook.com/fx/config_1.3/global.php on line 9 Warning : Cannot modify header information - headers already sent by output started at /mnt/data/www.nxtbook.com/fx/config_1.3/global.php:9 in /mnt/data/www.nxtbook.com/fx/config_1.3/global.php on line 10 McBrien and Antler The Column www.thecolumn.eu.com December 2006 Figure 4: A composite chromatogram for two subsamples with LC-UV and LC–MS detection with summary peak table. The chromatogram s for each subsample are combined post-acquisition to create a virtual composite sample. 1 3 .3 6 1 0 .8 6 1 1 .4 5 1 2 .1 3 1 3 .6 9 1 4 .8 5 4 .7 3 4 6 8 10 12 14 16 Retention time min Average retention times for composite sample Subsample 1 — acid degradation S1-UV S1-MS Subsample 2 — heat degradation S2-MS S2-UV 8.97 9.02 9.02 9.02 8.92 8.92 8.27 8.37 8.37 8.37 8.18 8.18 11.64 11.64 11.63 11.65 - 12.13 12.32 12.31 12.32 11.94 11.94 10.86 10.78 10.78 10.78 10.94 10.94 13.81 13.81 13.81 13.36 13.35 13.35 13.35 13.37 13.37 1 7 .6 3 1 7 .7 5 18 8 .2 7 8 .9 7 14.85 14.44 14.44 14.44 15.25 15.25 17.63 17.56 17.56 17.56 17.71 17.71 17.75 17.91 17.9 17.91 17.59 17.59 4.73 4.91 4.91 4.55 4.55 All components below limit of detection. References Supplies & Services the classified directory from The Column To advertise in this section call Laura Howell today on +44 0 1244 393 149 or email: lhowell@advanstar.com to reserve your space CHROMATOGRAPHY STATION 1. L. R. Snyder, J. J. Kirkland and J. L. Glajch, Practical HPLC Method Development, 2nd Edition, Wiley-Interscience 1997 . 2. DryLab, Rheodyne LLC, http://www.rheodyne.com/products/chromatography/drylab/, Accessed 23 November 2006. 3. ACD/Method Development Suite, Advanced Chemistry Development, Inc., www.acdlabs.com/meth_develop/, Accessed 23 November 2006. 4. ChromSword, Iris Technologies International, Ltd., http://www.iristechnologies.net/ChromSword/ChromSwordAutoMain.htm, Accessed November 23, 2006. 5. M.E. Swartz and P.R. Brown, Chirality, 8, 67–76 1996 . 6. A. Bogomolov and M. McBrien, Anal. Chim. Acta, 490, 41–58 2003 . 7. G. Xue et al., J. Chrom. A, 1050, 159–71 2004 . 8. M. McBrien, 29th International Symposium on High Performance Liquid Phase Separations & Related Techniques HPLC 2006, San Francisco, California, USA. 17–23 June 2006. http://www.acdlabs.com/publish/publ06/hplc06_md.html Michael McBrien is the chromatography product manager at Advanced Chemistry Development Inc. Toronto, Canada . He can be reached at Michael.mcbrien@acdlabs.com Margaret Antler is a technical specialist for chromatography and mass spectrometry software at Advanced Chemistry Development Inc. Toronto, Canada . She can be reached at Margaret.antler@acdlabs.com Website: www.acdlabs.com 20 Warning : Unknown : The session id contains invalid characters, valid characters are only a-z, A-Z and 0-9 in Unknown on line 0 Warning : Unknown : Failed to write session data files . Please verify that the current setting of session.save_path is correct /var/lib/php/session in Unknown on line 0 http://www.thecolumn.eu.com http://www.rheodyne.com/products/chromatography/drylab/ http://www.acdlabs.com/meth_develop/ http://www.iristechnologies.net/ChromSword/ChromSwordAuto-Main.htm http://www.iristechnologies.net/ChromSword/ChromSwordAuto-Main.htm http://www.acdlabs.com/publish/publ06/hplc06_md.html http://www.acdlabs.com http://www.dataapex.com

Table of Contents for the Digital Edition of The Column - December 2006

Contents
News
Opinion
Market Trends and Analysis
Systematic Development of Stability-Indicating Methods
Supplies and Services
SPE Product Directory

The Column - December 2006

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