Agilent Measurement Journal - Issue 3 - 2007 - (Page 9)

the creation of application-speciﬁc LabChip® kits that address the four major steps of a typical workﬂow in life sciences research: 1. RNA isolation (RNA 6000 Nano LabChip kit) 2. Gene-expression analysis (DNA LabChip kit) 3. Protein expression (cell ﬂuorescence LabChip kit and cell assay extension) 4. Protein puriﬁcation (Protein 200 Plus LabChip kit) Step by step, researchers can pursue a complete workﬂow by learning and using one instrument and its set of applicationspeciﬁc analysis kits. platform integrates data and results from multiple applications and provides comprehensive statistical analysis, data-mining and visualization tools to answer myriad research questions. The results are impressive. In one case, the use of parallel gene expression proﬁling (GeneSpring GX) and genotyping analysis (GeneSpring GT) revealed new potential disease pathways in a pioneering study on schizophrenia and bipolar disorder. As another example, GeneSpring GT let researchers identify a speciﬁc gene that contributes to sudden infant death syndrome. In the past, this may have taken years, but it took less than a week with GeneSpring. Working at the enterprise level Automating complex analyses Analyzing environmental samples that contain a large number of target compounds is a complex application performed thousands of times every day. To improve efﬁciency and reduce costs, environmental laboratories can beneﬁt from application-speciﬁc software that automates these complex workﬂows. The Agilent deconvolution reporting software (DRS) provides fast and accurate interpretation of gas chromatography/mass spectrometry (GC/MS) data, especially in complex samples with high matrix contamination. DRS locates and isolates target spectra from co-eluting interferences and then compares the extracted spectrum with application-speciﬁc databases to detect the target compound, saving time and improving data quality by reducing the false negatives that often occur in manual comparisons. We have extended DRS with databases speciﬁc to environmental, food-safety and forensic applications. Experiments and measurements exist within the larger context of today’s business environment, which includes challenges such as employee productivity, operational and performance metrics, and corporate and regulatory mandates. Factors such as resource constraints, competitive pressures and industry consolidation further complicate the situation. The Agilent business process management (BPM) solution helps organizations address these challenges by streamlining, automating and optimizing mission-critical business processes while enabling collaboration between people, processes and information. With modules such as an enterprise workﬂow engine for managing business process execution, BPM helps identify and eliminate process bottlenecks, shortens process cycle times, reduces the risk of noncompliance, optimizes resource utilization and increases process automation. Looking to the future Extracting insights from large data sets Numerous experiments across multiple lines of inquiry can generate tremendous amounts of data. Breaking down barriers between the scientiﬁc disciplines depends on researchers’ ability to efﬁciently sift through multiple data sets, ﬁnd signiﬁcant results and pinpoint meaningful connections. We offer a variety of life sciences informatics tools to enhance this part of the workﬂow. One example is our GeneSpring analysis platform, which was developed to answer biological questions at the intersection of genomics, genetics, proteomics and biomarker screening. The Our ongoing dialog with opinion-leader customers will continue to help us identify new ways to augment our solutions and further optimize their workﬂows. Every aspect of the workﬂow — from sample preparation to informatics analysis — contributes to improved business results and better collaboration within and across organizations. For our customers, the ultimate payoff is the ability to achieve new breakthroughs sooner while meeting their overall business goals, which will help them thrive in an increasingly competitive business environment. LabChip and the LabChip logo are registered trademarks of Caliper Technologies Corp. in the U.S. and other countries. Agilent Measurement Journal 9

Table of Contents Feed for the Digital Edition of Agilent Measurement Journal - Issue 3 - 2007

Applying Ingenuity to the Measurement of Emerging Technologies Contents Emerging Innovations Department Delivering Bigger Benefits by Optimizing Customer Workflows Measuring Material Properties at the Nanoscale Utilizing In Situ Atomic Force Microscopy in Life Science, Pharmaceutical and other Bio-Related Applications WiMAX™: Plotting a New Path to Global Mobility Addressing the Triple Complexity of Triple-Play Networks What Next for Mobile Telephony? Exploring the Inner Workings of Tire-Pressure Monitoring Systems Developing, Assessing and Applying a High-Resolution Thin-Film Magnetic Probe Making Accurate Settling-Time Measurements Using a Vector Network Analyzer Applying Metabolomics Methods to the Study of Bacterial Leaf Blight in Rice Plants Measuring Stream Dynamics with Fiber Optics survey

Agilent Measurement Journal - Issue 3 - 2007

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