ASH News Daily - Saturday, December 10, 2011 - (Page A-15)
Saturday, December 10, 2011
QUALITY
The Importance of Quality Indicators —
By aManda Brandow, do, MS
What You Need to Know Now
Center. In particular, presenters
will discuss how quality indicator
measures are derived, how they can
be measured, the potential consequences
of failure to adhere to these
indicators, and the challenges that
quality indicators pose to particular
hematologic populations.
Dr. Richard Lottenberg, Univer-
A
re established quality indicators
of sufficient quality
for individual populations?
This afternoon, attendees will have
the opportunity to learn about the
importance of quality indicators at
the ASH special symposium, “Quality
Indicators: Examples of Relevance
to Hematology” that will be
held from 2:00 to 3:30 p.m. in Room
30 of the San Diego Convention
sity of Florida, Gainesville, will discuss
the challenges in defining the
quality of health care for patients
with sickle cell disease (SCD). Spe-
ASH NEWS DAILY
Page A–15
®
cifically, Dr. Lottenberg will discuss
how the small number of randomized,
controlled trials in SCD poses
challenges for the development of
quality indicators. In addition, he
will present recent developments
relevant to the establishment of quality
indicators in SCD and the benefits
of having well-defined quality
indicators in SCD. Dr. Lottenberg
will highlight how operationalizing
quality indicators in SCD is a work
in progress, since there are real chal-
lenges to providing SCD care even
when there is strong evidence for
improved outcomes.
Dr. Lottenberg will also discuss
the need to be aware of unintended
consequences when developing
quality indicators for SCD. “There
needs to be validation of outcome
measures. We need to assure quality
indicators serve to enhance the
capabilities of providers, rather
»» QUALITY Page A-18
Tweets
from
An innovative approach to improving outcomes in patients with cancer
This could allow potent
Antibody-drug conjugates (ADCs) use a conditionally stable linker to combine the targeting specificity of
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Optimizing the parameters for clinical success
Scientists at Seattle Genetics are focused on parameters critical to the effective performance of ADCs,
including target antigen selection,3,4
linker stability5-7
and potent cytotoxic agents.4,7,8
Elements of an antibody-drug conjugate
Linker
Antibody
specific for a tumor-associated
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Cytotoxic agent
kills target cells when
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attaches the cytotoxic agent to
the antibody. Newer linker
systems are designed to be
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targeted cancer cells4,8,9
ADCs link precision and
potency for greater activity
A preclinical (in vivo) study demonstrated
that the ADC is more active than the
antibody alone (mAb) or the admixture
(mAb + cytotoxic agent unlinked)10
#ASH11
Chewing on great career development
advice at #ASH11
Simultaneously exciting and
ulcer-inducing... – prknlot
At Successes in Bone Marrow
Failures Symposium. Good session
at #ASH11 – marrow
Excited to hear updates from
my colleagues attending @
ASH_hematology annual meeting.
#ASH11 – hayeslat
Loving 68 degree weather
and palm trees in San diego.
#ASH11 – alantanmd
Science editor en route to
#ASH11. If the crew needs to
ask “is there a doctor on the
plane?” they will be all SET. –
BioWorld
Kind of geeking out that
#ASH11 has its own iPhone
app! – deepfriedlard
The future of drug treatment in cancer
Seattle Genetics is dedicated to improving the lives of people with cancer by developing
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Go to seattlegenetics.com for your complimentary, comprehensive, 15-slide
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Just landed for #ASH11 and
there is a guy in just boxers at the
baggage claim... – derekwimmer
Here in #ASH11 waiting T-cell
lymphoma session. San Diego
CA – humbertosinco
Leadership in antibody-drug
conjugate development
www.seattlegenetics.com
REFERENCES: 1. Ducry L, Stump B. Antibody-drug conjugates: linking cytotoxic payloads to monoclonal antibodies.
Bioconjug Chem. 2010;21(1):5-13. 2. Wu AM, Senter PD. Arming antibodies: prospects and challenges for
immunoconjugates. Nat Biotechnol. 2005;23(9):1137-1146. 3. Carter P, Smith L, Ryan M. Identification and validation
of cell surface antigens for antibody targeting in oncology. Endocr Relat Cancer. 2004;11(4):659-687. 4. Carter PJ,
Senter PD. Antibody-drug conjugates for cancer therapy. Cancer J. 2008;14(3):154-169. 5. Alley SC, Benjamin DR,
Jeffrey SC, et al. Contribution of linker stability to the activities of anticancer immunoconjugates. Bioconjug Chem.
2008;19(3):759-765. 6. Chari RVJ. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem
Res. 2008;41(1):98-107. 7. Alley SC, Okeley NM, Senter PD. Antibody-drug conjugates: targeted drug delivery
for cancer. Curr Opin Chem Biol. 2010;14(4):529-537. 8. Senter PD. Potent antibody drug conjugates for cancer
therapy. Curr Opin Chem Biol. 2009;13(3):235-244. 9. Polson AG, Calemine-Fenaux J, Chan P, et al. Antibody-drug
conjugates for the treatment of non–Hodgkin’s lymphoma: target and linker-drug selection. Cancer Res. 2009;69(6):
2358-2364. 10. Doronina SO, Toki BE, Torgov MY, et al. Development of potent monoclonal antibody auristatin
conjugates for cancer therapy. Nat Biotechnol. 2003;21(7):778-784.
Seattle Genetics and
© 2011 Seattle Genetics, Inc., Bothell, WA 98021
All rights reserved.
are US registered trademarks of Seattle Genetics, Inc.
Printed in USA
US/ADC/2011/0030
Just got back from #ASH11 registration.
Loved the monitor for
the Twitter Feed. Are you following
@ASH_hematology?
Lisa_Palacios
–
Headed out to San Diego for
#ASH11. – jghoggatt
Join the annual meeting
conversation on Twitter. Use
#ASH11 in your tweets from the
meeting. Follow ASH on
Twitter (@ash_hematology)
for Society news, meeting
information, advocacy updates,
and much more.
10/25/11 2:37 PM
Table of Contents for the Digital Edition of ASH News Daily - Saturday, December 10, 2011
ASH News Daily - Saturday, December 10, 2011
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