ASH News Daily 2012 - Sunday, December 9, 2012 - (Page B-43)

Sunday, December 9, 2012 ASH NewS DAily paths in this beautiful, outdoor park. The premier green space and central gathering place of Atlanta also has tennis and basketball courts, an Aquatic Center, a playground area, and small and large dog parks. The William Breman Jewish Heritage Museum www.thebreman.org 1440 Spring Street NW Open: Mon. – Thurs. from 10:00 a.m. to 5:00 p.m.; Fri. from 10:00 a.m. to 3:00 p.m.; and Sun. from 1:00 to 5:00 p.m. Closed Saturday. Admission: Free to members. Visit the website to join. Non-mem- Page B–43 ® Jimmy Carter Presidential Library and Museum. (© 2012, AtlantaPhotos.com) ber fees are as follows: Adults - $12, seniors (62+) - $8, students - $6, children (3-6) - $4, children under 3 - free. The Breman, Atlanta’s only Jewish museum, offers visitors a full experience of Jewish art, history, and culture. Throughout its galleries and exhibitions, the Breman endeavors to explore universal themes of diversity, community, dignity, and responsibility through the lens of the Jewish experience. There are also two permanent exhibitions, Absence of Humanity: The Holocaust Years, and Creating Community: The Jews of Atlanta from 1845 to the Present, which depicts life in the state of Georgia. Underground Atlanta http://underground-atlanta.com 50 Upper Alabama Street Open: Mall hours - Mon. – Thurs. from 10:00 a.m. to 8:00 p.m.; Fri. and Sat. from 10:00 a.m. to 9:00 p.m.; Sun. from 12:00 noon to 6:00 p.m. Restaurant and club hours may vary. Admission: Varies. Please visit the website. With more than six blocks of shopping, dining, history, and entertainment, you can truly experience it all at Underground Atlanta. Choose from an array of restaurants, take a guided tour, or pay a visit to Kenny’s Alley in the Five Points neighborhood of downtown Atlanta. World of Coca-Cola www.worldofcoca-cola.com 121 Baker Street NW Open: Daily, December 7 and 8 from 9:00 a.m. to 6:30 p.m., December 9 – 11 from 10:00 a.m. to 6:30 p.m. Last tickets sold at 5:00 p.m. Admission: General (Adult) - $16; VIP Guided Tour - $26. Explore the whimsical world of the world’s most famous beverage brand. Have a cold one at the beverage lounge, witness the dynamics of a bottling line, or watch a 3-D movie chronicling the history of Coca-Cola. Zoo Atlanta www.zooatlanta.org 800 Cherokee Avenue SE Open: Mon. – Fri. from 9:30 a.m. to 5:30 p.m.; ticket booths close at 4:30 p.m. Sat. and Sun. from 9:30 a.m. to 6:30 p.m; ticket booths close at 5:30 p.m. Admission: Adults (12+) - $20.99, seniors (65+), military, and college students - $16.99, children (3-11) $15.99. Zoo Atlanta houses more than 1,500 animals including the largest collections of gorillas and orangutans in the United States. The city attractions were selected from www.Atlanta.net. Leadership in antibody-drug conjugate development Antibody-drug conjugates (ADCs) use a conditionally stable linker to combine the specificity of monoclonal antibodies with the power of cytotoxic agents.1,2 This could allow drugs to be delivered directly to targeted cells and limit systemic toxicity. Optimizing the parameters for clinical success Scientists at Seattle Genetics are focused on parameters critical to the effective performance of ADCs, including target antigen selection,3,4 linker stability5-7 and cytotoxic agents.4,7,8 Elements of an antibody-drug conjugate Linker Antibody Specific for a tumor-associated antigen that has restricted expression on normal cells.4,8 Cytotoxic agent Attaches the cytotoxic agent to the antibody. Newer linker systems are designed to be stable in circulation and release the cytotoxic agent inside targeted cells.4,8,9 ADCs link precision and potency for greater activity A preclinical (in vivo) study demonstrated that the ADC is more active than the antibody alone (mAb) or the admixture (mAb + cytotoxic agent unlinked)10 Designed to kill target cells when internalized and released.4,8 The future of drug treatment in cancer Seattle Genetics is dedicated to improving the lives of people with cancer by developing innovative therapies for hematologic malignancies and solid tumors. For more information about Seattle Genetics and ADC technology, visit seattlegenetics.com. Leadership in antibody-drug conjugate development www.seattlegenetics.com REFERENCES: 1. Ducry L, Stump B. Antibody-drug conjugates: linking cytotoxic payloads to monoclonal antibodies. Bioconjug Chem. 2010;21(1):5-13. 2. Wu AM, Senter PD. Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol. 2005;23(9):1137-1146. 3. Carter P, Smith L, Ryan M. Identification and validation of cell surface antigens for antibody targeting in oncology. Endocr Relat Cancer. 2004;11(4):659-687. 4. Carter PJ, Senter PD. Antibody-drug conjugates for cancer therapy. Cancer J. 2008;14(3):154-169. 5. Alley SC, Benjamin DR, Jeffrey SC, et al. Contribution of linker stability to the activities of anticancer immunoconjugates. Bioconjug Chem. 2008;19(3):759-765. 6. Chari RVJ. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem Res. 2008;41(1):98-107. 7. Alley SC, Okeley NM, Senter PD. Antibody-drug conjugates: targeted drug delivery for cancer. Curr Opin Chem Biol. 2010;14(4):529-537. 8. Senter PD. Potent antibody drug conjugates for cancer therapy. Curr Opin Chem Biol. 2009;13(3):235-244. 9. Polson AG, Calemine-Fenaux J, Chan P, et al. Antibody-drug conjugates for the treatment of non–Hodgkin’s lymphoma: target and linker-drug selection. Cancer Res. 2009;69(6): 2358-2364. 10. Doronina SO, Toki BE, Torgov MY, et al. Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat Biotechnol. 2003;21(7):778-784. Seattle Genetics and are US registered trademarks of Seattle Genetics, Inc. © 2012 Seattle Genetics, Inc., Bothell, WA 98021 All rights reserved. Printed in USA US/BVP/2012/0113 2860_sgn35_fa2_adc_ashnd.indd 2 10/15/12 5:22 PM  http://www.thebreman.org http://www.AtlantaPhotos.com http://www.underground-atlanta.com http://www.worldofcoca-cola.com http://www.zooatlanta.org http://www.Atlanta.net

Table of Contents for the Digital Edition of ASH News Daily 2012 - Sunday, December 9, 2012

ASH News Daily 2012 - Sunday, December 9, 2012

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