ASH News Daily 2014 - Day 4 - (Page A-1)

Read this issue online at www.hematology.org/ashnewsdaily2014_tuesday Follow us on Twitter using #ASH14 Schedule 7:00 a.m. - 1:30 p.m. Registration Moscone West, Lobby - First Floor 7:15 - 9:15 a.m. Special Symposium on the Basic Science of Hemostasis and Thrombosis* (invited presentations) Moscone North, Rooms 120-125) 7:30 - 9:00 a.m. Simultaneous Oral Sessions 7:30 - 9:00 a.m. Late-Breaking Abstracts Session Moscone North, Hall D 9:30 - 9:45 a.m. Announcement of Awards Dameshek Prize, Stratton Medal, and Mentor Award Moscone North, Hall D 9:45 - 11:15 a.m. Presidential Symposium Moscone North, Hall D 11:15 - 11:45 a.m. Business Meeting Moscone North, Hall D 11:30 noon - 1:00 p.m. Best of ASH Moscone North, Hall D IN THIS SECTION Choosing Wisely A-2 Presidential Symposium A-3 Checkpoint Blockades A-5 Late Breaking Abstracts A-7 Iron and Its Strange Bedfellows By John J. StrouSe, Md, Phd Y esterday morning, ASH honored Dr. Tomas Ganz from the University of California, Los Angeles, with the E. Donnall Thomas Lecture. Dr. Ganz is known for his earth-shaking research in iron homeostasis and after an introduction by ASH President, Dr. Linda Burns, Dr. Ganz presented his enthralling lecture on the sexy story of entanglement between iron, erythropoiesis, and host defense and did not disappoint. The plot began with the history of the study of iron in medicine and its important role in human health and disease. Dr. Ganz then focused on the explosion in our understanding of the molecular underpinnings of iron metabolism and iron homeostasis at the level of the organism and cell. Dr. Ganz is well recognized for his isolation (from many gallons of urine) and characterization of hepcidin, a master regulator of iron homeostasis that Dr. Ganz describes as follows: "Hepcidin is to iron as insulin is to glucose." The propeptide of hepcidin is made and secreted by hepatocytes and then cleaved to the active 25 amino acid form by furin. In the discussion, Dr. Ganz reviewed the role of hepcidin in both the regulation of intestinal iron absorption »» IRON Page A-4 Sickle Cell Disease: An Unfinished Jigsaw Puzzle By IfeyInwa (Ify) oSunkwo, Md, MPh S ickle cell disease (SCD) was first reported in 1910 in a dental student who presented with recurrent episodes of pain and anemia. Since that time, researchers and clinicians have struggled to understand the complex mechanisms responsible for the heterogeneous manifestations of this disease. Yesterday, Dr. Michael DeBaun of Vanderbilt University School of Medicine in Nashville and Dr. Robert Hebbel of the University of Minnesota in Minneapolis presented Dr. Michael DeBaun delivers his half of the Ernest Beutler Lecture Monday. DeBaun appears in front of a slide of "Ten Redefined," a sickle cell pain awareness painting created by Haitian artist Hertz Nazaire. Dr. Robert Hebbel also received this year's prize and delivered the other half of the lecture. the 2014 Ernest Beutler Lecture in recognition of their revolutionary contributions toward the science and clinical treatment of SCD. This award was established to honor two outstanding individuals who have advanced the field of hematology in the areas of basic science and clinical translational research. Starting the session "Sickle Cell Anemia: Improved Understanding but Continued Challenges" Dr. DeBaun presented outcomes of sentinel SCD clinical trials including his work on understanding the epidemiology and treatment of silent cerebral infarcts. Dr. DeBaun showed data that 30 percent of school-age children have silent cerebral infarcts that are associated with a mean five-point reduction in IQ points that progresses over time. Bringing the conversation to a more global level, he reminded the audience »» PUZZLE Page A-4 http://www.hematology.org/ashnewsdaily2014_tuesday

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ASH News Daily 2014 - Day 4

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