Counseling Points - January 2009 - (Page 5)

Table 1. Stimulant Medications for ADHD Available Forms Dosage Strengths Dosing Schedule Approximate Duration of Action and Pattern of Release FDA Approved for Adults? FDA-approved, Maximum Dose* Medication Active Ingredient Amphetamines Scored tablet Capsule Tablet 5 mg, 10 mg 5 mg, 10 mg, 15 mg 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg Daily BID Spansule Capsule BID or TID 5 mg, 10 mg, 15 mg, 20 mg, 25 mg, 30 mg Daily Yes No, used off label No, used off label Yes 8-12 hours; 2 equal doses 4 hours apart 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg, 20 mg, 30 mg BID or TID 4-6 hours; 100% released immediately No, used off label 40 mg 30 mg 40 mg 40 mg 70 mg Adderall® Mixed amphetamine salts (amphetaminedextroamphetamine) Adderall XR® Mixed amphetamine salts Dexedrine® Dextroamphetamine Dexedrine Spansule® Dextroamphetamine Vyvanse™ Lisdexamfetamine 4-5 hours; 100% released immediately 6-8 hours; 40% released immediately and 60% continuously Up to 12 hours; released continuously Methylphenidates Concerta® Methylphenidate HCL 18 mg, 27 mg, 36 mg, 54 mg Daily 10 mg, 15 mg, 20 mg, 30 mg Daily BID, TID Daily or BID BID Daily 2.5 mg, 5 mg, 10 mg 5 mg, 10 mg, 15 mg, 20 mg 5 mg, 10 mg, 20 mg 10 mg, 20 mg, 30 mg, 40 mg 9-12 hours; 22% released immediately and 78% continuously 9 -12 hours; continuously No, used off label but application has been made for treatment in adults No, used off label No, used off label Yes No, used off label No, used off label 72 mg Daytrana™ Patch Tablet Capsule Scored tablet Methylphenidate Extendedrelease tablet with immediaterelease outer coating Transdermal patch 30 mg 20 mg 20 mg 60 mg 60 mg 5 Capsule Extendedrelease tablet 10 mg, 18 mg, 25 mg, 40 mg, 60 mg, 80 mg, 100 mg 150 mg, 300 mg Daily Daily Scored tablet; transdermal patch 0.1 mg, 0.2 mg, 0.3 mg Tablet: BID, TID, QID Patch: Every 7 days (up to every 5 days) 1 mg, 2 mg BID, TID Tablet Focalin® Focalin® XR Dexmethylphenidate HCL Dexmethylphenidate HCL Ritalin® Methylphenidate HCL Ritalin LA® ExtendedMethylphenidate HCL release capsule 4-6 hours; 100% released immediately 6-10 hours; 2 equal doses 4 hours apart 2-4 hours; 100% released immediately 8 hours; 2 equal doses 4 hours apart Nonstimulants 24 hours; can take 4-8 weeks to see extent of improvement 24 hours No, used off label No, used off label 90-100 mg 300 mg Strattera® Atomoxetine HCL Wellbutrin XL® Bupropion HCL Alpha Agonists 2.4 mg (adults) 4-5 days No, used off label 0.4 mg (children) 6-12 hours Currently being studied in long-acting form and FDA approval expected 4 mg Catapres® Catapres-TTS® Clonidine HCL JANUARY 2009 Tenex® Guanfacine HCL BID=twice daily; QID=four times daily; TID=three times daily. *Usually based on data in children. Sources: Drug package inserts.

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Counseling Points - January 2009

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