Foundation for the NIH, Annual Report 2007

GAIN: Genetic Association Information Network In 2007, the Genetic Association Information Network (GAIN) completed an ambitious program to genotype existing research studies in six major common diseases, and combine the results with clinical data to create a significant new resource for genetic researchers. The network’s goal is to help find genetic causes for common diseases, and its initial efforts focused on Attention Deficit Hyperactivity Disorder, diabetic nepropathy in type I diabetes, major depression, psoriasis, schizophrenia, and bipolar disorder. The resulting data are being deposited in a database within the National Library of Medicine at NIH, funded by GAIN, for the broad use of the research community. By comparing the genetic makeup of healthy people with that of people with the disease, scientists should be better able to target diagnosis, treatment, and prevention strategies. Originators of the initial studies have received additional grants to make their own analyses. Managed by the Foundation for NIH, GAIN combines the resources and expertise of several public and private entities to streamline the genetic research process. The program’s protocols for protecting participant privacy and confidentiality have served as a model for similar studies across the scientific community. The Foundation for NIH has raised $26 million for the network in cash and in-kind resources, primarily from Pfizer Inc and Affymetrix, Inc. PARTNERS IN GAIN INCLUDE Abbott Laboratories Affymetrix, Inc. Broad Institute of the Massachusetts Institute of Technology and Harvard University Perlegen Sciences, Inc. Pfizer Inc GAIN has genotyped over 18,000 samples in six major common diseases in less than 18 months. FOUNDATION FOR THE NATIONAL INSTITUTES OF HEALTH WWW.FNIH.ORG | 9 http://WWW.FNIH.ORG

Table of Contents Feed for the Digital Edition of Foundation for the NIH, Annual Report 2007

Foundation for the NIH, Annual Report 2007 Contents Letter from the Chairman and Executive Director Year in Review The Biomarkers Consortium Osteoarthritis Initiative - OAI Alzheimer's Disease Neuroimaging Initiative - ADNI Genetic Association Information Network - GAIN Grand Challenges in Global Health - GCGH Comprehensive T Cell Vaccine Immune Monitoring Consortium - CTC-VIMC Global Health Security Initiative - GHSI Collaborative Summit on Breast Cancer Research AVON-NCI Progress for Patients Awards Program Targeted Cancer Therapies Tutorials Measures for Clinical Trials of Treatment of Congnition Clinical Research Training Program - CRTP Program Listing Edmond J. Safra Family Lodge Endowments Fiancial Summary Donors Board of Directors Advisory Boards Staff

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