Clinical OMICs - Issue 8 - (Page 4)

Patient-Derived Xenografts for Cancer Therapeutics Development and Predictive Modeling Speakers Webinars Free Registration! www.GENengnews.com/xenograft Philip C. Mack, Ph.D. Associate Adjunct Professor and Director of Pharmacology UC Davis Cancer Center Chong-Xian Pan, M.D., Ph.D. Associate Professor, Hematology and Oncology, UC Davis Cancer Center Walter Ausserer, Ph.D. Senior Business Unit Manager, In Vivo Pharmacology Services, The Jackson Laboratory View it Now! On Demand 4 Patient-derived xenograft (PDX) tumor models retain much of the biological diversity and heterogeneity of the original patient tumor. Recent advances in the development of these models and their increasing sophistication have led to their increasing use for anticancer drug research and development and as predictive clinical models. In this webinar, experts from the University of California, Davis Comprehensive Cancer Center will describe their experience using PDX tumor models derived from fresh clinical samples of human lung and bladder tumors. Philip C. Mack, Ph.D., and ChongXian Pan, M.D., Ph.D., will discuss whole exome, transcriptome, and microRNA sequencing, followed by computational biological analysis to identify genetic alterations validated with immunofluorescence and immunohistochemical staining. The presenters will also discuss the details of PDX molecular characterization studies, including driver mutations and copy number variation. In addition, the implications of recent PDX studies for patient selection and treatment algorithms will be addressed. Produced with support from Clinical OMICs August 13, 2014 www.clinicalomics.com Publisher & CEO Editor In Chief Mary Ann Liebert John Sterling Group Publisher Sande Giaccone (sgiaccone@clinicalomics.com) Managing Editor Tamlyn L. Oliver (toliver@clinicalomics.com) Production Editor Senior Editor Technical Editor Online Editor Senior News Editor Robert M. Reis Kevin Mayer Patricia F. Dimond, Ph.D. Patrice Bartell Alex Philippidis Assistant Editor Sunya Bhutta Art Director James Lambo Director, Digital Media Bill Levine Audience Development Kwafo Anoff Online Product Manager Thomas Mathew Web Producer Melinda Kucsera Sales Administrator Michelle Stolowicki Online Editorial Assistant Katherine Vuksanaj Design & Layout Nora Wertz Advertising Material Wanda Sanchez wsanchez@liebertpub.com The views, opinions, findings, conclusions, and recommendations set forth in any article in Clinical Omics are solely those of the authors of those articles and do not necessarily reflect the views, policy, or position of Clinical Omics, its Publisher, or its editorial staff and should not be attributed to any of them. All advertisements are subject to review by the Publisher. The acceptance of advertisements does not constitute an endorsement of the product or service advertised. Clinical Omics (ISSN-2334-1351) is published online semimonthly by Mary Ann Liebert, Inc., 140 Huguenot Street, 3rd Floor, New Rochelle, NY 10801-5215. For subscription information go to: www.clinicalomics.com Copyright © 2014 by Mary Ann Liebert, Inc., New Rochelle, NY. www.clinicalomics.com http://www.clinicalomics.com http://www.GENengnews.com/xenograft http://www.GENengnews.com/xenograft http://www.clinicalomics.com http://www.clinicalomics.com

Table of Contents for the Digital Edition of Clinical OMICs - Issue 8

Contents

Clinical OMICs - Issue 8