Clinical OMICs - Volume 3, Issue 3 - (Page 3)

Molecular Diagnostics in Personalized Medicine Variants identified in a multigene panel test can seem like the dots in a connectthe-dots puzzle-only many of the dots are unnumbered. Regardless, patterns are emerging in clinical cancer genetics. CLINICAL ACTIONABILITY IN CANCER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Interpreting mutations piled higher and deeper. LIQUID BIOPSY THRUSTS NON-INVASIVE MOLECULAR DIAGNOSTICS INTO THE CLINICAL ARENA . . . . . . . . . . . . . . . . . . .11 Two experts in the emerging field of liquid biopsy share their visions for the future of diagnostic medicine. EPIGENETICS RESEARCH REVEALS A RANGE OF CLINICAL POSSIBILITIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Advantageously, epigenetic analyses can capture both genetic factors and environmental exposures. PCR HAS A HISTORY OF AMPLIFYING ITS GAME . . . . . . . . . . . . . . .21 A brief timeline of how PCR ascended to the pinnacle of molecular methodologies. Regular Features CASE STUDY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25 Designing Amplicon Panels Bioo Scientific asserts that amplicon sequencing can benefit from a machine-learning approach to primer design, and highmultiplexing systems for deep sequencing. INNOVATOR . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .28 From DNA to Diagnosis without Delay To date, genome sequencing has tended to rely on software-based approaches, but specialized hardware platforms are starting to emerge that are faster and more convenient. NEWS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Cover: iStock / vitanovski Above (top): iStock / rbv; (bottom): Instituto Bernabeu www.clinicalomics.com NEW PRODUCTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .19 MEETING ROUNDUP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .33 March 2016 Clinical OMICs 3 https://www.youtube.com/channel/UCXBPPWZv--Ne4NfAUHcc8hg https://twitter.com/ClinicalOMICs http://www.clinicalomics.com

Table of Contents for the Digital Edition of Clinical OMICs - Volume 3, Issue 3

Contents

Clinical OMICs - Volume 3, Issue 3