Clinical OMICs - Volume 3, Issue 9 - 13
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in-house are on the rise, owing to the
growth of industry-wide support for
LC-MS.
Using LC-MS laboratories can rapidly develop or replicate novel tests for
the clinical assessment of a patient's
disease state in a way that conventional immunoassays are unable to in
the same time frame. For instance, the
narrow therapeutic index and unpredictable pharmacokinetics of many
immunosuppressants necessitates
the post-treatment monitoring of
drug distribution and response. Clinical laboratories are adopting LC-MS
over conventional immunoassays for
these analyses, as they offer improved
analyte specificity and reduced
matrix effects, allowing clinicians to
sensitively balance therapeutic efficacy against adverse side effects. In
www.clinicalomics.com
addition, LC-MS allows for the simultaneous analysis of multiple immunosuppressants in tandem, a useful
tool when monitoring patients taking
multiple therapies1.
Offering improved analyte
specificity and reduced matrix
effects, LC-MS allows clinicians
to balance therapeutic efficacy
against adverse side effects
Incorrect analyses can be problematic. For example, immunoassay-based analyses conducted on
thyroid cancer patients are often
unable to distinguish between clinically relevant biomarkers for disease
progression such as thyroglobin and
autoantibodies produced in the body,
leading to false readings2. The specificity offered by LC-MS systems means
this interference is avoided. This
makes it a significant tool, not only
for monitoring treatment response
and disease classification, but also for
evaluating therapeutic uptake and
identifying any toxic effects a drug
may be having on a patient.
Lessons Learned
from Clinical Research
The field of clinical research continues to leverage the power of LC-MS
technology in new ways. One study
used the intracellular IG1R/AKT/
mTOR signaling pathway to evaluate the suitability of multiplex-immunoprecipitation and targeted MS
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September 2016 Clinical OMICs
13
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Table of Contents for the Digital Edition of Clinical OMICs - Volume 3, Issue 9
Contents
Clinical OMICs - Volume 3, Issue 9 - Cover1
Clinical OMICs - Volume 3, Issue 9 - Cover2
Clinical OMICs - Volume 3, Issue 9 - Contents
Clinical OMICs - Volume 3, Issue 9 - 4
Clinical OMICs - Volume 3, Issue 9 - 5
Clinical OMICs - Volume 3, Issue 9 - 6
Clinical OMICs - Volume 3, Issue 9 - 7
Clinical OMICs - Volume 3, Issue 9 - 8
Clinical OMICs - Volume 3, Issue 9 - 9
Clinical OMICs - Volume 3, Issue 9 - 10
Clinical OMICs - Volume 3, Issue 9 - 11
Clinical OMICs - Volume 3, Issue 9 - 12
Clinical OMICs - Volume 3, Issue 9 - 13
Clinical OMICs - Volume 3, Issue 9 - 14
Clinical OMICs - Volume 3, Issue 9 - 15
Clinical OMICs - Volume 3, Issue 9 - 16
Clinical OMICs - Volume 3, Issue 9 - 17
Clinical OMICs - Volume 3, Issue 9 - 18
Clinical OMICs - Volume 3, Issue 9 - 19
Clinical OMICs - Volume 3, Issue 9 - 20
Clinical OMICs - Volume 3, Issue 9 - 21
Clinical OMICs - Volume 3, Issue 9 - 22
Clinical OMICs - Volume 3, Issue 9 - 23
Clinical OMICs - Volume 3, Issue 9 - 24
Clinical OMICs - Volume 3, Issue 9 - 25
Clinical OMICs - Volume 3, Issue 9 - 26
Clinical OMICs - Volume 3, Issue 9 - 27
Clinical OMICs - Volume 3, Issue 9 - 28
Clinical OMICs - Volume 3, Issue 9 - 29
Clinical OMICs - Volume 3, Issue 9 - 30
Clinical OMICs - Volume 3, Issue 9 - 31
Clinical OMICs - Volume 3, Issue 9 - 32
Clinical OMICs - Volume 3, Issue 9 - 33
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