Psychiatry 2008 - September 2008 - (Page 55)

[journal watch] psychosis. After two years of treatment, 36 (72%) completed the trial, 39 (78%) showed a clinical response of 50%, 4 of those relapsed, and 32 (64%) achieved remission. Authors conclude that RLAI was well tolerated and appears to be effective in recent-onset psychosis. PMID: 18344732 Long-acting injectable risperidone v. olanzapine tablets for schizophrenia or schizoaffective disorder. randomised, controlled, openlabel study. Keks NA, Ingham M, Khan A, Karcher K. Br J Psychiatry. 2007 Aug;191:131-9. Synopsis: Researchers compared the effectiveness of long-acting risperidone to that of oral olanzapine in 377 patients diagnosed with schizophrenia or schizoaffective disorder, and, based on the results, concluded that both treatments were efficacious and well tolerated. PMID: 17666497 ALCOHOL AND SUBSTANCE USE Timing models of reward learning and core addictive processes in the brain. Ross D. Behav Brain Sci. 2008 Aug;31(4):457-458. Synopsis: Author examines the hypothesis that all addiction involves neuroadaptation that attenuates serotonergic inhibition of a mesolimbic dopamine system that has learned that cues for consumption of the addictive target are signals of a high-reward-rate environment. PMID: 18662482 A review of addiction. Clay SW, Allen J, Parran T. Postgrad Med. 2008 Jul 31;120(2):E01-E07. Synopsis: In this article, authors discuss the two major neurological pathways involved in addiction, the mesolimbic dopamine reward pathway and the altering of the decision-making prefrontal cortex, as well as pharmaceuticals available for the individualized treatment of addiction and the physician’s role in treating addiction. PMID: 18654058 Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs. Cunha-Oliveira T, Rego AC, Oliveira CR. Brain Res Rev. 2008 Jun;58(1):192-208. Epub 2008 Mar 27. Synopsis: In this review, authors synthesize the literature on cellular and molecular alterations induced by amphetamines, cocaine and opiates in neuronal systems, and also discuss mechanisms of the neurotoxic effects of drugs of abuse such as oxidative stress, mitochondrial dysfunction, apoptosis and inhibition of neurogenesis. PMID: 18440072 Behavioral reactivity and addiction: the adaptation of behavioral response to reward opportunities. Trafton JA, Gifford EV. J Neuropsychiatry Clin Neurosci. 2008 Winter;20(1):23-35. Review. Synopsis: Authors examine a neurobiological mechanism by which behavioral therapies help patients recovering from addiction to abstain from drug use. PMID: 18305282 Ms. Alexander is a freelance writer/editor who lives in New Orleans, Louisiana. Discover our Passion for Excellence While Rediscovering Yours BC/BE Psychiatrist needed to serve as Medical Director of an 11-bed Inpatient Behavioral Health Services Unit. Call is shared with five local psychiatrists. Practice is located at Aspirus Wausau Hospital, recognized as the only hospital in Wisconsin, and one of just 63 in the nation, to receive the HealthGrades Distinguished Hospital Award for Clinical Excellence in each of the past five years (2004-2008). Work with a great team of young, vibrant psychiatrists. There is great potential for program growth and development with a focus on expanded community action. Excellent compensation and benefit package included. As you work within the open and inviting architecture of Aspirus, you will be part of our outstanding award-winning facility. We invite you to join a first-rate medical community and a family-friendly quality of life in north central Wisconsin. Please contact Jamie Sitko today at 800-792-8728 or fax CV to 715-847-2742. Email: jamiesi@aspirus.org www.aspirus.org [SEPTEMBER] Psychiatry 2008 55 http://www.aspirus.org http://www.aspirus.org

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Psychiatry 2008 - September 2008 Editor’s Message Editorial Advisory Board Contents Psych Rx Letters to the Editor Use of Benzodiazepines in the Treatment of Anxiety Functional Neurosurgery in the Treatment of Severe Obsessive Compulsive Disorder and Major Depression: Overview of Disease Circuits and Therapeutic Targeting for the Clinician Treatment of Comorbid Adolescent Cannabis Use and Major Depressive Disorder Risperidone Long-acting Injections: Successful Alternative Deltoid Muscle Injections for Refractory Schizophrenia Alcohol/Substance Misuse and Treatment Nonadherence: Fatal Attraction Transforming the Psychiatric Inpatient Unit from Short-term Pseudo-asylum Care to State-of-the-art Treatment Setting Journal Watch Classified Advertising Information for Authors

Psychiatry 2008 - September 2008

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