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(SSBs) are associated not only with weight gain but also with increased risk of T2DM. This relationship remains significant even after adjusting for BMI, suggesting that the adverse impact of SSBs is not entirely mediated through excess weight [Schulze MB et al. JAMA 2004]. Dr. Hu also discussed modern dietary patterns as they relate to the phenomenon of inflammation and diabetes morbidity. Several epidemiological studies demonstrate the association of elevated plasma concentrations of inflammatory cytokines, such as TNF alpha, interleukin-6, and C-reactive protein, and increased risk of diabetes. A dietary pattern that is characterized by higher intake of SSBs, refined grains, processed meats, and margarine and lower intake of wine, coffee, and vegetables is strongly associated with inflammatory cytokine concentrations and risk of T2DM [Schulze MB et al. Am J Clin Nut 2005]. These data provide epidemiological evidence to link overall dietary patterns, inflammation, and diabetes risk, said Dr. Hu. The Thrifty Genotype Versus Thrifty Phenotype Returning to the theme of the international/ethnic differences in diabetes risk, Dr. Hu reviewed several potential mechanisms for increased susceptibility to diabetes in Asians. First, Asians tend to exhibit the metabolically obese phenotype of increased central or abdominal obesity despite having a normal BMI. Second, Asians may have an enhanced genetic predisposition to diabetes, due to over-representation of the so-called “thrifty genotype.” Third, exposure to undernutrition in utero, which is common in Asian populations, may have long-term consequences on risk of T2DM and other metabolic diseases in later life. Finally, there might be interactions between genetic predispositions regarding T2DM risk and rapid changes in diet and lifestyle. Ethnic differences in insulin sensitivity have been consistently demonstrated. Using an euglycemic clamp, one group of investigators found that among age- and BMI-matched young adults, Caucasians have the highest insulin sensitivity, followed by Chinese and South Asians. As measured by homeostasis model assessment of insulin resistance, Southeast Asians and Indians exhibit the highest resistance, whereas Caucasians have the lowest insulin resistance [Dickinson S et al. J Nutr 2002]. The “thrifty genotype,” a hypothesis that was proposed by James Neel, postulates that obesity and T2DM are caused by positive selection of genotypic efficiency in metabolism and energy storage, thereby conferring advantage in times of nutrient scarcity but leading to obesity during a modern age of abundance [Neel JV. Am J Hum Genet 1962; Neel JV. Bull World Health Organ 1999]. This hypothesis, seen in historical perspective, may explain the extraordinary rates
of diabetes that have been seen amongst the Pima Indians. However, there is little empirical evidence that the obesity and diabetes genes that have been identified so far are “positively selected.” Extending the idea of the thrifty genotype to the microenvironment, it is further proposed to explain the observation that exposure to intrauterine undernutrition, a condition that is highly common in rural Asia, leads to fetal phenotype programming of decreased beta-cell function. When subsequently exposed to a Westernized diet in adult life, the risk of diabetes is significantly increased. In a recent study, Dr. Hu and colleagues found that exposure to the Chinese famine (1959-1961) during fetal life was significantly associated with increased risk of hyperglycemia and T2DM in adulthood. This association appears to be exacerbated by a nutrition-rich environment in later life (Li et al. Diabetes 2010 Jul 13. [Epub ahead of print]). This observation is consistent with the “thrifty phenotype” hypothesis. Is the Die Cast? What Does This Mean? Given current economic trends, it seems clear that the Eastern hemisphere will increasingly adopt the dietary and lifestyle patterns of the West. In light of a strong “obesogenic” environment, coupled with genetic predisposition for diabetes, the global diabetes epidemic has no sign of abating. However, said Dr. Hu, T2DM is largely preventable through diet and lifestyle modifications. Dr. Hu’s work in the Nurses’ Health Study cohort supports this assertion, demonstrating that 90% of potential diabetes incidence could be prevented by lifestyle interventions [Hu FB et al. N Engl J Med 2001]. In the China Da Qing study, there was a sustained 40% reduction in risk for the intervention group at 14 years follow-up postintervention (Li G et al. Lancet 2008]. It is remarkable that nearly all of the participants in the control group converted from impaired glucose tolerance to diabetes during the study period. Intervention trials that were conducted in Finland, the US, and India have also demonstrated the benefits of lifestyle intervention for diabetes prevention. As demonstrated by the DPP group, the benefits of lifestyle intervention have the potential to counteract the increased risk that is conferred by the TCF7L2 genotype [Florez JC et al. N Engl J Med 2006]. In closing, Dr. Hu warned that T2DM has become a global public health crisis that threatens the health and economy of all nations and developing countries in particular. The good news is that the majority of T2DM cases can be prevented through diet and lifestyle modification. However, the adoption of a healthy diet and lifestyle requires not only individual behavioral changes but also changes in our food and social environments.
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Highlights from the American Diabetes Association 70th Annual Scientific Sessions
http://www.mdconferencexpress.com/
Table of Contents for the Digital Edition of MD Conference Express
MD Conference Express
Contents
Real-Time Continuous Glucose Monitoring and Diabetes Treatment
The Globalization of Diabetes
Treat the Individual, Tend to the Population
Microvascular Outcomes from the ACCORD Trial
Diabetic Retinopathy in the ACCORD Trial
Results from the STAR 3 Study
Findings from HELP PD
Insights from the BARI 2D Trial
Effect of Atorvastatin on Beta Cell Function
Caffeine Supplementation Reduces Exercise Induced Hypoglycemia
Cardiometabolic Risk
Point of Care Devides
Newer Insulins
Diabetes, Glycemia and Cardiovascular Disease: Is it Time to Rethink the Regulatory Approach?
Diabetes and Cancer: ADA Consensus Statement
The Diabetic Foot Wound
HEALTHY Study - Middle School-Based Intervention to Reduce Diabetes Risk
MD Conference Express
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