Biotechnology Healthcare - July/August 2008 - (Page 4) Biotechnology Healthcare JULY/AUGUST 2008 The Official Journal of the Biologic Finance and Access Council FEATURE ARTICLES COVER STORY M POLICY THE IMPACT OF BIOLOGICS ON HEALTH, BUSINESS, AND BENEFITS www.biotechnologyhealthcare.com A Decade of Trial, Error, False Starts, and Hope 18 Ten years into the modern biologics era, access- and cost-management techniques still aren’t refined. Why has managing biologics proven so much harder than managing other drugs? What strategies might help payers face the challenges of the future? What Path Will Comparative Effectiveness Research Take? 27 As existing biologics gain indications and new drugs make it to market, the array of choices makes it challenging to pick the right treatment for a given patient. Clinical effectiveness is the most important factor, but at the policy level, cost has to enter the discussion. Where? Q&A Stem Cells: Health Insurance You Can Bank On 45 Robin Smith, MD, MBA, isn’t claiming she has found the fountain of youth, but she is certain her company, NeoStem, can help prevent many costly, debilitating scourges of older age. FOCUS: RHEUMATOID ARTHRITIS AT A GLANCE: Rheumatoid Arthritis 16 Prevalence of disease, economics of care, and implications for payers, as told in charts. THERAPEUTICS M RA Therapies in Development: A New Generation of Relief 32 The first generation of RA biologics was good, but just the start. A new group of therapies — some novel, some familiar, but all powerful and each with a niche — will energize this market. COST MANAGEMENT Assessing the Full Impact of RA on Employers and Payers 37 M Paresh Chaudhari, PharmD, MPH, frames the business case for employers to look beyond the direct medical costs of treatment of RA and consider employee health benefits as an investment. DEPARTMENTS Openers 2 Olympian feats, cover to cover. Editorial/David B. Nash, MD, MBA 6 Of pride, alarm, and hope. DrugTrack 7 Approvals, research, and conference coverage. Health Plan Confidential 9 Better guidance for off-label coverage? Specialty Pharmacy 50 The evolution of SP and where it’s heading. Employer to Employer 52 GM’s challenges in managing biologics. Personalized Medicine 54 Declaring war on warfarin misdosing. Trends 57 Specialty drug utilization growth slows. BIOTECHNOLOGY HEALTHCARE (ISSN 1554-169x) is published bimonthly by BioCommunications LLC, 780 Township Line Road, Yardley, PA 19067. This is Volume 5, Number 2. Standard postage paid at Morrisville, Pa., and at additional mailing offices. Price: $18 per copy, $95 per year in the United States; $120 per year elsewhere. Phone: (267) 685-2788; fax (267) 6852966; paid subscription inquiries (267) 685-2789. Letters to the editor will be considered for publication and should be sent to the address above. Copyright 2008, BioCommunications LLC. INDEXED BY CINAHL AND INTERNATIONAL PHARMACEUTICAL ABSTRACTS COVER: JOHN STILL http://www.biotechnologyhealthcare.com
Table of Contents Feed for the Digital Edition of Biotechnology Healthcare - July/August 2008 Biotechnology Healthcare - July/August 2008 Openers Contents Editorial/David B. Nash, MD, MBA Drug Track Health Plan Confidential Rheumatoid Arthritis A Decade of Trial, Error, False Starts, and Hope What Path Will Comparative Effectiveness Research Take? RA Therapies in Development: A New Generation of Relief Assessing the Full Impact of RA on Employers and Payers Stem Cells: Health Insurance You Can Bank On Specialty Pharmacy Employer to Employer Personalized Medicine Trends Clinical Briefs Biotechnology Healthcare - July/August 2008 Biotechnology Healthcare - July/August 2008 - Biotechnology Healthcare - July/August 2008 (Page CoverA) Biotechnology Healthcare - July/August 2008 - Biotechnology Healthcare - July/August 2008 (Page CoverB) Biotechnology Healthcare - July/August 2008 - Biotechnology Healthcare - July/August 2008 (Page CoverC) Biotechnology Healthcare - July/August 2008 - Biotechnology Healthcare - July/August 2008 (Page CoverD) Biotechnology Healthcare - July/August 2008 - Biotechnology Healthcare - July/August 2008 (Page 1) Biotechnology Healthcare - July/August 2008 - Openers (Page 2) Biotechnology Healthcare - July/August 2008 - Openers (Page 3) Biotechnology Healthcare - July/August 2008 - Contents (Page 4) Biotechnology Healthcare - July/August 2008 - Contents (Page 5) Biotechnology Healthcare - July/August 2008 - Editorial/David B. Nash, MD, MBA (Page 6) Biotechnology Healthcare - July/August 2008 - Drug Track (Page 7) Biotechnology Healthcare - July/August 2008 - Drug Track (Page 8) Biotechnology Healthcare - July/August 2008 - Health Plan Confidential (Page 9) Biotechnology Healthcare - July/August 2008 - Health Plan Confidential (Page 10) Biotechnology Healthcare - July/August 2008 - Health Plan Confidential (Page 11) Biotechnology Healthcare - July/August 2008 - Health Plan Confidential (Page 12) Biotechnology Healthcare - July/August 2008 - Health Plan Confidential (Page 13) Biotechnology Healthcare - July/August 2008 - Health Plan Confidential (Page 14) Biotechnology Healthcare - July/August 2008 - Health Plan Confidential (Page 15) Biotechnology Healthcare - July/August 2008 - Rheumatoid Arthritis (Page 16) Biotechnology Healthcare - July/August 2008 - Rheumatoid Arthritis (Page 17) Biotechnology Healthcare - July/August 2008 - A Decade of Trial, Error, False Starts, and Hope (Page 18) Biotechnology Healthcare - July/August 2008 - A Decade of Trial, Error, False Starts, and Hope (Page 19) Biotechnology Healthcare - July/August 2008 - A Decade of Trial, Error, False Starts, and Hope (Page 20) Biotechnology Healthcare - July/August 2008 - A Decade of Trial, Error, False Starts, and Hope (Page 21) Biotechnology Healthcare - July/August 2008 - A Decade of Trial, Error, False Starts, and Hope (Page 22) Biotechnology Healthcare - July/August 2008 - A Decade of Trial, Error, False Starts, and Hope (Page 23) Biotechnology Healthcare - July/August 2008 - A Decade of Trial, Error, False Starts, and Hope (Page 24) Biotechnology Healthcare - July/August 2008 - A Decade of Trial, Error, False Starts, and Hope (Page 25) Biotechnology Healthcare - July/August 2008 - A Decade of Trial, Error, False Starts, and Hope (Page 26) Biotechnology Healthcare - July/August 2008 - What Path Will Comparative Effectiveness Research Take? (Page 27) Biotechnology Healthcare - July/August 2008 - What Path Will Comparative Effectiveness Research Take? (Page 28) Biotechnology Healthcare - July/August 2008 - What Path Will Comparative Effectiveness Research Take? (Page 29) Biotechnology Healthcare - July/August 2008 - What Path Will Comparative Effectiveness Research Take? (Page 30) Biotechnology Healthcare - July/August 2008 - What Path Will Comparative Effectiveness Research Take? (Page 31) Biotechnology Healthcare - July/August 2008 - RA Therapies in Development: A New Generation of Relief (Page 32) Biotechnology Healthcare - July/August 2008 - RA Therapies in Development: A New Generation of Relief (Page 33) Biotechnology Healthcare - July/August 2008 - RA Therapies in Development: A New Generation of Relief (Page 34) Biotechnology Healthcare - July/August 2008 - RA Therapies in Development: A New Generation of Relief (Page 35) Biotechnology Healthcare - July/August 2008 - RA Therapies in Development: A New Generation of Relief (Page 36) Biotechnology Healthcare - July/August 2008 - Assessing the Full Impact of RA on Employers and Payers (Page 37) Biotechnology Healthcare - July/August 2008 - Assessing the Full Impact of RA on Employers and Payers (Page 38) Biotechnology Healthcare - July/August 2008 - Assessing the Full Impact of RA on Employers and Payers (Page 39) Biotechnology Healthcare - July/August 2008 - Assessing the Full Impact of RA on Employers and Payers (Page 40) Biotechnology Healthcare - July/August 2008 - Assessing the Full Impact of RA on Employers and Payers (Page 41) Biotechnology Healthcare - July/August 2008 - Assessing the Full Impact of RA on Employers and Payers (Page 42) Biotechnology Healthcare - July/August 2008 - Assessing the Full Impact of RA on Employers and Payers (Page 43) Biotechnology Healthcare - July/August 2008 - Assessing the Full Impact of RA on Employers and Payers (Page 44) Biotechnology Healthcare - July/August 2008 - Stem Cells: Health Insurance You Can Bank On (Page 45) Biotechnology Healthcare - July/August 2008 - Stem Cells: Health Insurance You Can Bank On (Page 46) Biotechnology Healthcare - July/August 2008 - Stem Cells: Health Insurance You Can Bank On (Page 47) Biotechnology Healthcare - July/August 2008 - Stem Cells: Health Insurance You Can Bank On (Page 48) Biotechnology Healthcare - July/August 2008 - Stem Cells: Health Insurance You Can Bank On (Page 49) Biotechnology Healthcare - July/August 2008 - Specialty Pharmacy (Page 50) Biotechnology Healthcare - July/August 2008 - Specialty Pharmacy (Page 51) Biotechnology Healthcare - July/August 2008 - Employer to Employer (Page 52) Biotechnology Healthcare - July/August 2008 - Employer to Employer (Page 53) Biotechnology Healthcare - July/August 2008 - Personalized Medicine (Page 54) Biotechnology Healthcare - July/August 2008 - Personalized Medicine (Page 55) Biotechnology Healthcare - July/August 2008 - Personalized Medicine (Page 56) Biotechnology Healthcare - July/August 2008 - Trends (Page 57) Biotechnology Healthcare - July/August 2008 - Clinical Briefs (Page CB1) Biotechnology Healthcare - July/August 2008 - Clinical Briefs (Page CB2) Biotechnology Healthcare - July/August 2008 - Clinical Briefs (Page CB3) Biotechnology Healthcare - July/August 2008 - Clinical Briefs (Page CB4) Biotechnology Healthcare - July/August 2008 - Clinical Briefs (Page CB5) Biotechnology Healthcare - July/August 2008 - Clinical Briefs (Page CB6) Biotechnology Healthcare - July/August 2008 - Clinical Briefs (Page CB7) Biotechnology Healthcare - July/August 2008 - Clinical Briefs (Page CB8) Biotechnology Healthcare - July/August 2008 - Clinical Briefs (Page CB8)
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