Managed Care - March 2008 - (Page 37) n n n n n Unique mechanism of action includes cardioselective beta blockade and vasodilation1* Significant BP reductions as monotherapy and in combination1-3 Effective across a broad range of patients1-3 Favorable tolerability profile with a low incidence of beta blocker-related side effects1,2 Once-daily antihypertensive with efficacy maintained over 24 hours 1 *In extensive metabolizers (most of the population) and at doses ≤10 mg, BYSTOLIC is preferentially 1 selective. The mechanism of action of the antihypertensive response of BYSTOLIC has not been definitively established. Possible factors that may be involved include: (1) decreased heart rate, (2) decreased myocardial contractility, (3) diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers, (4) suppression of renin activity, and (5) vasodilation and decreased peripheral vascular resistance. Please see brief summary of full Prescribing Information on last page of this advertisement. For full Prescribing Information visit www.BYSTOLIC.com. http://www.BYSTOLIC.com http://www.BYSTOLIC.com
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