Managed Care - April 2008 - (Page 20) A unique mechanism of action Unique mechanism of action includes cardioselective beta blockade and vasodilation1* BYSTOLIC Cardioselectivity 1 Vasodilation 1† Additional properties: Suppression of renin activity and diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers1 *In extensive metabolizers (most of the population) and at doses ≤10 mg, BYSTOLIC is preferentially 1 selective. The mechanism of action of the antihypertensive response of BYSTOLIC has not been definitively established. Possible factors that may be involved include: (1) decreased heart rate, (2) decreased myocardial contractility, (3) diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers, (4) suppression of renin activity, and (5) vasodilation and decreased peripheral vascular resistance. † Vasodilation occurs independently from 1 blockade.
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