Pharmacy & Therapeutics - February 2008 - (Page 102)

Antifibrinolytic Therapy in Cardiothoracic Surgery Table 2 Detailed Study Results Aminocaproic Acid No. hospitals No. cases Avg cases/hosp/3 years Range of cases Avg age (years) Avg LOS (days) Avg cost/case ($) 20 12,397 620 7–2,395 60.9 12.6 54,088 Aminocaproic Acid, CTS No. hospitals No. cases Avg cases/hosp/3 years Total range of cases Avg age (SD/median) (years) Male Race, white Race, black Race, other Race, unknown Mortality Mortality (major or extreme SOI) Avg LOS (days) Median LOS Total cases (avg ICU case/hosp/3 years) Avg ICU LOS (SD) Median ICU LOS Avg cost/case Median cost/case Severity, minor Severity, moderate Severity, major Severity, extreme Total, major + extreme One day drug therapy Two days drug therapy Three days drug therapy 18 9,751 542 5–2072 63.3 (13.8/64.5) 6787 6,416 589 1,535 1,211 251 237 10.0 8 9,045 (503) 3.52 (4.22) 2 $42,369 $34,727 1,273 4,174 3,409 895 4,304 9,170 543 38 % 78.7 % Aprotinin 19 9,340 491 8–1,565 52 15.8 73,160 Aprotinin, CTS 19 6,855 361 1–1,385 52.6 (25.8/60.1) 4,369 4,488 1,060 1,004 303 357 336 11.9 9 5,059 (266) 5.42 (6.5) 3 $51,330 $40,614 755 2,065 2,805 1,230 4,035 6,234 590 31 % Tranexamic Acid 4 17 % % 73.4 Controls, CTS 20 46,123 2,306 348–8,566 60.1 (19.6/63.9) 28,290 32,299 5,557 4,765 3,502 1,801 1,715 7.9 6 22,644 (1,132) 4.54 (6.99) 3 $32,465 $24,594 9,979 17,563 13,232 5,349 18,581 % 69.6 65.8 6.0 15.7 12.4 2.6 5.5 63.7 65.5 15.5 14.6 4.4 5.2 8.3 61.3 70.0 12.0 10.3 7.6 3.9 9.2 13.1 42.8 35.0 9.2 44.1 94.0 5.6 0.4 11.0 30.1 40.9 17.9 58.9 90.9 8.6 0.5 21.6 38.1 28.7 11.6 40.3 All cases ARF (584.X as secondary Dx) 603 6.2 748 10.9 2,793 6.1 Cases ARF (584.X as secondary Dx + major or extreme SOI) 602 14.0 747 18.5 2,774 14.9 All cases ARF + hemodialysis 112 1.1 232 3.4 462 1.0 Cases ARF + hemodialysis + major or extreme SOI 112 2.6 232 5.7 460 2.5 All cases hemodialysis (Px = 39.95, not Dx V541 or V560) 271 2.8 442 6.4 1,209 2.6 Hemodialysis + major or extreme SOI 236 5.5 412 10.2 1,007 5.4 ACEI = angiotensin-converting enzyme–inhibitor; AMI = acute myocardial infarction; ARF = acute renal failure; avg = average; CABG = coronary artery bypass grafting; CTS = cardiothoracic surgery; Dx = diagnosis; GI = gastrointestinal; hosp = hospital; ICU = intensive-care unit; LOS = length of stay; Px = procedure; SD = standard deviation; SOI = severity of illness. 102 P&T® • February 2008 • Vol. 33 No. 2

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Pharmacy & Therapeutics - February 2008 Contents Editorial Medication Errors Prescription: Washington The Language of (Forgive Us) Change, As P&T Enters the Digital Age New Drugs/Drug News/New Medical Devices Drug Forecast Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States Evaluation of the Management of Acute Venous Thromboembolism and Its Outcomes: One Institution's Experience American Society of Hematology, 49th Annual Meeting Pharmaceutical Approval Update

Pharmacy & Therapeutics - February 2008

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