Pharmacy & Therapeutics - February 2008 - (Page 78) New BYSTOLIC. Significant blood pressure reductions with a favorable tolerability profile. Important Safety Information Patients being treated with BYSTOLIC should be advised against abrupt discontinuation of therapy. Severe exacerbation of angina and the occurrence of myocardial infarction and ventricular arrhythmias have been reported following the abrupt cessation of therapy with beta blockers. When discontinuation is planned, the dosage should be reduced gradually over a 1- to 2-week period and the patient carefully monitored. BYSTOLIC is contraindicated in severe bradycardia, heart block greater than first degree, cardiogenic shock, decompensated cardiac failure, sick sinus syndrome (unless a permanent pacemaker is in place), severe hepatic impairment (Child-Pugh >B), and in patients who are hypersensitive to any component of this product. BYSTOLIC should be used with caution in patients with peripheral vascular disease, thyrotoxicosis, in patients treated concomitantly with beta blockers and calcium channel blockers of the verapamil and diltiazem type (ECG and blood pressure should be monitored), severe renal impairment, and any degree of hepatic impairment or in patients undergoing major surgery. Caution should also be used in diabetic patients as beta blockers may mask some of the manifestations of hypoglycemia, particularly tachycardia. In general, patients with bronchospastic disease should not receive beta blockers. BYSTOLIC should not be combined with other beta blockers. The most common adverse events with BYSTOLIC versus placebo (approximately ≥1% and greater than placebo) were headache, fatigue, dizziness, diarrhea, nausea, insomnia, chest pain, bradycardia, dyspnea, rash, and peripheral edema.
Table of Contents Feed for the Digital Edition of Pharmacy & Therapeutics - February 2008 Pharmacy & Therapeutics - February 2008 Contents Editorial Medication Errors Prescription: Washington The Language of (Forgive Us) Change, As P&T Enters the Digital Age New Drugs/Drug News/New Medical Devices Drug Forecast Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States Evaluation of the Management of Acute Venous Thromboembolism and Its Outcomes: One Institution's Experience American Society of Hematology, 49th Annual Meeting Pharmaceutical Approval Update Pharmacy & Therapeutics - February 2008 Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page Cover1) Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page Cover2) Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page 59) Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page 60) Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page 61) Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page 62) Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page 63) Pharmacy & Therapeutics - February 2008 - Contents (Page 64) Pharmacy & Therapeutics - February 2008 - Contents (Page 65) Pharmacy & Therapeutics - February 2008 - Contents (Page 66) Pharmacy & Therapeutics - February 2008 - Contents (Page 67) Pharmacy & Therapeutics - February 2008 - Contents (Page 68) Pharmacy & Therapeutics - February 2008 - Editorial (Page 69) Pharmacy & Therapeutics - February 2008 - Medication Errors (Page 70) Pharmacy & Therapeutics - February 2008 - Medication Errors (Page 71) Pharmacy & Therapeutics - February 2008 - Medication Errors (Page 72) Pharmacy & Therapeutics - February 2008 - Prescription: Washington (Page 73) Pharmacy & Therapeutics - February 2008 - The Language of (Forgive Us) Change, As P&T Enters the Digital Age (Page 74) Pharmacy & Therapeutics - February 2008 - The Language of (Forgive Us) Change, As P&T Enters the Digital Age (Page 75) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 76) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 77) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 78) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 79) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 80) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 81) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 82) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 83) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 84) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 85) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 86) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 87) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 88) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 89) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 90) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 91) Pharmacy & Therapeutics - February 2008 - Drug Forecast (Page 92) Pharmacy & Therapeutics - February 2008 - Drug Forecast (Page 93) Pharmacy & Therapeutics - February 2008 - Drug Forecast (Page 94) Pharmacy & Therapeutics - February 2008 - Drug Forecast (Page 95) Pharmacy & Therapeutics - February 2008 - Drug Forecast (Page 96) Pharmacy & Therapeutics - February 2008 - Drug Forecast (Page 97) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 98) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 99) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 100) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 101) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 102) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 103) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 104) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 105) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 106) Pharmacy & Therapeutics - February 2008 - Evaluation of the Management of Acute Venous Thromboembolism and Its Outcomes: One Institution's Experience (Page 107) Pharmacy & Therapeutics - February 2008 - Evaluation of the Management of Acute Venous Thromboembolism and Its Outcomes: One Institution's Experience (Page 108) Pharmacy & Therapeutics - February 2008 - Evaluation of the Management of Acute Venous Thromboembolism and Its Outcomes: One Institution's Experience (Page 109) Pharmacy & Therapeutics - February 2008 - Evaluation of the Management of Acute Venous Thromboembolism and Its Outcomes: One Institution's Experience (Page 110) Pharmacy & Therapeutics - February 2008 - American Society of Hematology, 49th Annual Meeting (Page 111) Pharmacy & Therapeutics - February 2008 - American Society of Hematology, 49th Annual Meeting (Page 112) Pharmacy & Therapeutics - February 2008 - American Society of Hematology, 49th Annual Meeting (Page 113) Pharmacy & Therapeutics - February 2008 - Pharmaceutical Approval Update (Page 114) Pharmacy & Therapeutics - February 2008 - Pharmaceutical Approval Update (Page 115) Pharmacy & Therapeutics - February 2008 - Pharmaceutical Approval Update (Page 116) Pharmacy & Therapeutics - February 2008 - Pharmaceutical Approval Update (Page 117)
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