Pharmacy & Therapeutics - February 2008 - (Page 83) Favorable tolerability profile and convenient once-daily dosing Overall low incidence of side effects1 Percentage of Adverse Events by Dose, Occurring in ≥1% of Patients Taking BYSTOLIC and More Frequently Than in Patients Taking Placebo1 Placebo (n=205) % BYSTOLIC 5 mg (n=459) % BYSTOLIC 10 mg (n=461) % BYSTOLIC 20-40 mg (n=677) % Adverse Event Headache Fatigue Dizziness Diarrhea Nausea Insomnia Chest pain Bradycardia Dyspnea Rash Peripheral edema 6 1 2 2 0 0 0 0 0 0 0 9 2 2 2 1 1 0 0 0 0 1 6 2 3 2 3 1 1 0 1 1 1 7 5 4 3 2 1 1 1 1 1 1 Pooled results from three U.S. phase III, 3-month, placebo-controlled studies of BYSTOLIC monotherapy for the treatment of mild to moderate hypertension (N=2016; n=1802). Overall low discontinuation rate2 n The discontinuation rate due to adverse events was 2.8% for BYSTOLIC vs 2.2% for placebo1 Flexible, once-daily dosing1 n Dose should be individualized to the needs of the patient; the recommended starting dose for most patients is 5 mg once daily. Dose can be increased at 2-week intervals up to 40 mg 1** Can be taken with or without food, as monotherapy or in combination with other agents1 n **Patients with severe renal impairment or moderate hepatic impairment should begin with an initial dose of 2.5 mg once daily; upward titration, if needed, should be performed cautiously. BYSTOLIC has not been studied in patients undergoing dialysis. See full Prescribing Information. References: 1. BYSTOLIC [package insert]. St. Louis, MO: Forest Pharmaceuticals, Inc.; 2007. 2. Data on file, Forest Laboratories, Inc. 3. Saunders E, Smith WB, DeSalvo KB, Sullivan WA. The efficacy and tolerability of nebivolol in hypertensive African American patients. J Clin Hypertens. 2007;9:866-875. ©2008 Forest Laboratories, Inc. 44-1012123R1 01/08 http://www.BYSTOLIC.com
Table of Contents Feed for the Digital Edition of Pharmacy & Therapeutics - February 2008 Pharmacy & Therapeutics - February 2008 Contents Editorial Medication Errors Prescription: Washington The Language of (Forgive Us) Change, As P&T Enters the Digital Age New Drugs/Drug News/New Medical Devices Drug Forecast Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States Evaluation of the Management of Acute Venous Thromboembolism and Its Outcomes: One Institution's Experience American Society of Hematology, 49th Annual Meeting Pharmaceutical Approval Update Pharmacy & Therapeutics - February 2008 Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page Cover1) Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page Cover2) Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page 59) Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page 60) Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page 61) Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page 62) Pharmacy & Therapeutics - February 2008 - Pharmacy & Therapeutics - February 2008 (Page 63) Pharmacy & Therapeutics - February 2008 - Contents (Page 64) Pharmacy & Therapeutics - February 2008 - Contents (Page 65) Pharmacy & Therapeutics - February 2008 - Contents (Page 66) Pharmacy & Therapeutics - February 2008 - Contents (Page 67) Pharmacy & Therapeutics - February 2008 - Contents (Page 68) Pharmacy & Therapeutics - February 2008 - Editorial (Page 69) Pharmacy & Therapeutics - February 2008 - Medication Errors (Page 70) Pharmacy & Therapeutics - February 2008 - Medication Errors (Page 71) Pharmacy & Therapeutics - February 2008 - Medication Errors (Page 72) Pharmacy & Therapeutics - February 2008 - Prescription: Washington (Page 73) Pharmacy & Therapeutics - February 2008 - The Language of (Forgive Us) Change, As P&T Enters the Digital Age (Page 74) Pharmacy & Therapeutics - February 2008 - The Language of (Forgive Us) Change, As P&T Enters the Digital Age (Page 75) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 76) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 77) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 78) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 79) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 80) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 81) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 82) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 83) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 84) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 85) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 86) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 87) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 88) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 89) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 90) Pharmacy & Therapeutics - February 2008 - New Drugs/Drug News/New Medical Devices (Page 91) Pharmacy & Therapeutics - February 2008 - Drug Forecast (Page 92) Pharmacy & Therapeutics - February 2008 - Drug Forecast (Page 93) Pharmacy & Therapeutics - February 2008 - Drug Forecast (Page 94) Pharmacy & Therapeutics - February 2008 - Drug Forecast (Page 95) Pharmacy & Therapeutics - February 2008 - Drug Forecast (Page 96) Pharmacy & Therapeutics - February 2008 - Drug Forecast (Page 97) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 98) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 99) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 100) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 101) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 102) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 103) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 104) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 105) Pharmacy & Therapeutics - February 2008 - Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States (Page 106) Pharmacy & Therapeutics - February 2008 - Evaluation of the Management of Acute Venous Thromboembolism and Its Outcomes: One Institution's Experience (Page 107) Pharmacy & Therapeutics - February 2008 - Evaluation of the Management of Acute Venous Thromboembolism and Its Outcomes: One Institution's Experience (Page 108) Pharmacy & Therapeutics - February 2008 - Evaluation of the Management of Acute Venous Thromboembolism and Its Outcomes: One Institution's Experience (Page 109) Pharmacy & Therapeutics - February 2008 - Evaluation of the Management of Acute Venous Thromboembolism and Its Outcomes: One Institution's Experience (Page 110) Pharmacy & Therapeutics - February 2008 - American Society of Hematology, 49th Annual Meeting (Page 111) Pharmacy & Therapeutics - February 2008 - American Society of Hematology, 49th Annual Meeting (Page 112) Pharmacy & Therapeutics - February 2008 - American Society of Hematology, 49th Annual Meeting (Page 113) Pharmacy & Therapeutics - February 2008 - Pharmaceutical Approval Update (Page 114) Pharmacy & Therapeutics - February 2008 - Pharmaceutical Approval Update (Page 115) Pharmacy & Therapeutics - February 2008 - Pharmaceutical Approval Update (Page 116) Pharmacy & Therapeutics - February 2008 - Pharmaceutical Approval Update (Page 117)
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