Pharmacy & Therapeutics - May 2008 - (Page 257) Today’s complicated skin and skin structure infections (cSSSIs): ADVERTISEMENT More layers of complexity Changing pathogens MRSA rates are rising dramatically, and gram negatives, including Pseudomonas aeruginosa and Enterobacteriaceae, are prevalent in hospitalized cSSSIs.1 Failure of initial therapy has significant consequences In a retrospective study of 47,219 patients admitted to the hospital for cSSSIs, failure of initial antibiotic therapy was associated with • longer duration of antibiotic therapy • longer hospital stays • higher total inpatient charges • higher risk of death compared with patients whose initial treatment was successful.2 Visit www.meetinginfectionchallenges.com to learn more. References: 1. Moet GJ, Jones RN, Biedenbach DJ, Stilwell MG, Fritsche TR. Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: report from the SENTRY antimicrobial surveillance program (1998-2004). Diagn Microbiol Infect Dis. 2007;57:7-13. 2. Edelsberg J, Berger A, Weber DJ, Mallick R, Kuznik A, Oster G. Clinical and economic consequences of failure of initial antibiotic therapy for hospitalized patients with complicated skin and skin-structure infections. Infect Control Hosp Epidemiol. 2008;29:160-169. © Ortho-McNeil-Janssen Pharmaceuticals, Inc. 2008 May 2008 02G095 http://www.meetinginfectionchallenges.com http://www.meetinginfectionchallenges.com
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