Pharmacy & Therapeutics - June 2008 - (Page 322) Sustainable results PRECiSE Patients in Clinical Remission1- 4 PRECiSE 2 HBI 4*† n=215 Open-label extension HBI 4 n=141 48%‡ Number of patients ~ 8 out of 10 120 n=103 n=78 1 year 80 40 0 Overall patient population 26 weeks 26 28 32 36 40 44 48 52 56 60 64 68 72 76 80 Weeks Chart represents patients in PRECiSE 2 who continued on CIMZIA therapy in PRECiSE 3 (n=141). *Baseline Harvey-Bradshaw Index (HBI) score of 9. † HBI5,6 – Accepted evaluation method in Crohn’s disease – Index that includes measures of general well-being and abdominal pain and mass – Easier to use in clinical practice than CDAI ‡ Refers to responders to 6-week, open-label induction therapy. ~1 out of 2 patients‡ achieved remission at 6 months1,2 – ~8 out of 10 of those patients continuing therapy maintained remission through 18 months3 PRECiSE 1—Overall Remission7§ CIMZIA P .05 Placebo 40 Patients (%) 29% 20 18% 0 Overall patient population Week 26 § Clinical response defined as 100-point reduction in CDAI score and clinical remission as CDAI score 150 points. Unique—first 26-week, double-blind, long-term, true placebo-controlled trial in Crohn’s disease7 Strict parameters—both coprimary end points had to be satisfied for clinical success 7 – Response at both weeks 6 and 26 required to reach primary end point 7§ Real world—included patients with or without baseline 5-ASAs, immunosuppressants, corticosteroids, or prior infliximab use 7
Table of Contents Feed for the Digital Edition of Pharmacy & Therapeutics - June 2008 Editorial Aliskiren Reduces Plasma Renin Activity Medication Errors Prescription: Washington New Drugs/Drug News/ New Medical Devices Drug Forecast Challenges in Evaluating and Standardizing Medical Devices in Health Care Facilities California e-Pedigree Rules Pose Challenges For Pharmacies Pharmaceutical Approval Update American Psychiatric Association At a Glance: Dermatology Trends in Managed Care Pharmacy & Therapeutics - June 2008 Pharmacy & Therapeutics - June 2008 - (Page Bellyband1) Pharmacy & Therapeutics - June 2008 - (Page Bellyband2) Pharmacy & Therapeutics - June 2008 - (Page CoverA) Pharmacy & Therapeutics - June 2008 - (Page CoverB) Pharmacy & Therapeutics - June 2008 - (Page CoverC) Pharmacy & Therapeutics - June 2008 - (Page CoverD) Pharmacy & Therapeutics - June 2008 - (Page 305) Pharmacy & Therapeutics - June 2008 - (Page 306) Pharmacy & Therapeutics - June 2008 - (Page 307) Pharmacy & Therapeutics - June 2008 - (Page 308) Pharmacy & Therapeutics - June 2008 - (Page 309) Pharmacy & Therapeutics - June 2008 - (Page 310) Pharmacy & Therapeutics - June 2008 - (Page 311) Pharmacy & Therapeutics - June 2008 - (Page 312) Pharmacy & Therapeutics - June 2008 - (Page 313) Pharmacy & Therapeutics - June 2008 - Editorial (Page 314) Pharmacy & Therapeutics - June 2008 - Editorial (Page 315) Pharmacy & Therapeutics - June 2008 - Editorial (Page 316) Pharmacy & Therapeutics - June 2008 - Editorial (Page 317) Pharmacy & Therapeutics - June 2008 - Editorial (Page 318) Pharmacy & Therapeutics - June 2008 - Aliskiren Reduces Plasma Renin Activity (Page 319) Pharmacy & Therapeutics - June 2008 - Medication Errors (Page 320) Pharmacy & Therapeutics - June 2008 - Medication Errors (Page 321) Pharmacy & Therapeutics - June 2008 - Medication Errors (Page 322) Pharmacy & Therapeutics - June 2008 - Medication Errors (Page 323) Pharmacy & Therapeutics - June 2008 - Medication Errors (Page 324) Pharmacy & Therapeutics - June 2008 - Medication Errors (Page 325) Pharmacy & Therapeutics - June 2008 - Medication Errors (Page 326) Pharmacy & Therapeutics - June 2008 - Prescription: Washington (Page 327) Pharmacy & Therapeutics - June 2008 - New Drugs/Drug News/ New Medical Devices (Page 328) Pharmacy & Therapeutics - June 2008 - New Drugs/Drug News/ New Medical Devices (Page 329) Pharmacy & Therapeutics - June 2008 - New Drugs/Drug News/ New Medical Devices (Page 330) Pharmacy & Therapeutics - June 2008 - New Drugs/Drug News/ New Medical Devices (Page 331) Pharmacy & Therapeutics - June 2008 - New Drugs/Drug News/ New Medical Devices (Page 332) Pharmacy & Therapeutics - June 2008 - New Drugs/Drug News/ New Medical Devices (Page 333) Pharmacy & Therapeutics - June 2008 - New Drugs/Drug News/ New Medical Devices (Page 334) Pharmacy & Therapeutics - June 2008 - New Drugs/Drug News/ New Medical Devices (Page 335) Pharmacy & Therapeutics - June 2008 - New Drugs/Drug News/ New Medical Devices (Page 336) Pharmacy & Therapeutics - June 2008 - Drug Forecast (Page 337) Pharmacy & Therapeutics - June 2008 - Drug Forecast (Page 338) Pharmacy & Therapeutics - June 2008 - Drug Forecast (Page 339) Pharmacy & Therapeutics - June 2008 - Drug Forecast (Page 340) Pharmacy & Therapeutics - June 2008 - Drug Forecast (Page 341) Pharmacy & Therapeutics - June 2008 - Drug Forecast (Page 342) Pharmacy & Therapeutics - June 2008 - Drug Forecast (Page 343) Pharmacy & Therapeutics - June 2008 - Drug Forecast (Page 344) Pharmacy & Therapeutics - June 2008 - Drug Forecast (Page 345) Pharmacy & Therapeutics - June 2008 - Drug Forecast (Page 346) Pharmacy & Therapeutics - June 2008 - Drug Forecast (Page 347) Pharmacy & Therapeutics - June 2008 - Challenges in Evaluating and Standardizing Medical Devices in Health Care Facilities (Page 348) Pharmacy & Therapeutics - June 2008 - Challenges in Evaluating and Standardizing Medical Devices in Health Care Facilities (Page 349) Pharmacy & Therapeutics - June 2008 - Challenges in Evaluating and Standardizing Medical Devices in Health Care Facilities (Page 350) Pharmacy & Therapeutics - June 2008 - Challenges in Evaluating and Standardizing Medical Devices in Health Care Facilities (Page 351) Pharmacy & Therapeutics - June 2008 - Challenges in Evaluating and Standardizing Medical Devices in Health Care Facilities (Page 352) Pharmacy & Therapeutics - June 2008 - Challenges in Evaluating and Standardizing Medical Devices in Health Care Facilities (Page 353) Pharmacy & Therapeutics - June 2008 - Challenges in Evaluating and Standardizing Medical Devices in Health Care Facilities (Page 354) Pharmacy & Therapeutics - June 2008 - Challenges in Evaluating and Standardizing Medical Devices in Health Care Facilities (Page 355) Pharmacy & Therapeutics - June 2008 - Challenges in Evaluating and Standardizing Medical Devices in Health Care Facilities (Page 356) Pharmacy & Therapeutics - June 2008 - Challenges in Evaluating and Standardizing Medical Devices in Health Care Facilities (Page 357) Pharmacy & Therapeutics - June 2008 - Challenges in Evaluating and Standardizing Medical Devices in Health Care Facilities (Page 358) Pharmacy & Therapeutics - June 2008 - Challenges in Evaluating and Standardizing Medical Devices in Health Care Facilities (Page 359) Pharmacy & Therapeutics - June 2008 - California e-Pedigree Rules Pose Challenges For Pharmacies (Page 360) Pharmacy & Therapeutics - June 2008 - California e-Pedigree Rules Pose Challenges For Pharmacies (Page 361) Pharmacy & Therapeutics - June 2008 - Pharmaceutical Approval Update (Page 362) Pharmacy & Therapeutics - June 2008 - Pharmaceutical Approval Update (Page 363) Pharmacy & Therapeutics - June 2008 - American Psychiatric Association (Page 364) Pharmacy & Therapeutics - June 2008 - At a Glance: Dermatology Trends in Managed Care (Page 365) Pharmacy & Therapeutics - June 2008 - At a Glance: Dermatology Trends in Managed Care (Page 366) Pharmacy & Therapeutics - June 2008 - At a Glance: Dermatology Trends in Managed Care (Page 367) Pharmacy & Therapeutics - June 2008 - At a Glance: Dermatology Trends in Managed Care (Page 368) Pharmacy & Therapeutics - June 2008 - At a Glance: Dermatology Trends in Managed Care (Page back)
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