Potential Antiatherogenic Actions of HDL HDL inhibits expression of endothelial cell adhesion molecules and MCP-1 Monocyte LDL MCP-1 Vessel Lumen Endothelium HDL inhibits oxidation of LDL-C Adhesion molecule LDL Cytokines Oxidized LDL Intima Macrophage HDL promotes efflux of cholesterol from foam cells MCP-1 = monocyte chemoattractant protein-1 Adapted from Barter PJ et al. Circ Res. 2004;95:764-772. Foam cell