Meta-Analysis: Effects of Nicotinic Acid Carotid Intima Media Thickness Study ARBITER-6-HALTS Thoenes M et al ARBITER-2 CLAS N 97 30 78 39 Treatment Mean (SD) -12 (36) -5 (11) 14 (104) -12 (20) N 111 15 71 39 Control Mean SD -1 (31) 9 (12) 44 (100) 12 (20) WMD (fixed) 95% Cl WMD (fixed) 95% Cl -12 (-21, -2) -14 (-21, -7) -30 (-63, -3) -25 (-34, -16) -17 (-22, -12) Total Test for heterogeneity: P = 0.13, I2 = 47.4% Test for overall effect: P < 0.0001 -100 -50 0 50 Annual change, μm/y 100 E. Bruckert et al, Atherosclerosis 210 (2010) 353-361