Dalcetrapib and Torcetrapib Appear to Differ in Mechanism of CETP Inhibition • Dalcetrapib binds to CETP, inducing a conformational change to CETP that hinders association to HDL1 • Dalcetrapib binds to CETP only2 CETP tor or ana HDL dal HDL • Torcetrapib binding to CETP is an irreversible high affinity complex of CETP inhibitor, HDL, and CETP2,3 NB: The clinical relevance of these differences is unknown; these compounds have not been studied in head-to-head clinical trials. 1Okamoto 3Clark H et al. Nature. 2000;406:203-207. RW et al. J Lipid Res. 2006;47:537-552. 2Niesor EJ et al. Atherosclerosis. 2008;199:231.