Hospital Pharmacy - July/August 2018 - 241

241

Dickerson et al
Table 1. Rankings of Significant Articles for Pharmacy Nutrition Support Practice.

No. of authors who
indicate high importancea

Title
Compher5
Bochicchio et al6
Braunschweig et al7
Diamond et al8
Wischmeyer et al9
Zaloga et al10
Yeh et al11

Greater protein and energy intake may be associated with improved mortality in
higher risk critically ill patients: a multicenter, multinational observational study
Results of a multicenter prospective pivotal trial of the first inline continuous
glucose monitor in critically ill patients
Role of timing and dose of energy received in patients with acute lung injury on
mortality in the Intensive Nutrition in Acute Lung Injury Trial (INTACT): a post
hoc analysis
Preventing the progression of intestinal failure-associated liver disease in infants
using a composite lipid emulsion: a pilot randomized controlled trial of SMOFlipid
A randomized trial of supplemental parenteral nutrition in underweight and
overweight critically ill patients: the TOP-UP pilot trial
Safety and efficacy of subcutaneous parenteral nutrition in older patients: a
prospective randomized multicenter clinical trial
Implementation of an aggressive enteral nutrition protocol and the effect on
clinical outcomes

6
5
5
5
5
5
4b

Note. Articles were listed in descending order by the number of author contributors who indicated that they were of high importance followed by
alphabetical order of the last name of the first investigator or author.
a
Out of a total of the 8 participating authors evaluating these articles.
b
The only article with 4 authors who indicate high importance. All remaining articles outside of this list had ≤3 authors who indicate high importance (see
the supplemental file for a complete listing of these articles).

Table 2. Significant Guidelines, Position, Recommendations, and
Consensus Papers (in Alphabetical Order by First Author).
Author(s)

Title
12

Arends et al

Arends et al13
Barazzoni et al14
Boullata et al15
Christensen et al16
Forbes et al17
Guenter et al18
Kumpf et al19
Kwo et al20
Mehta et al21
Stoppe et al22
Weimann et al23
Worthington et al24

ESPEN guidelines on nutrition in cancer
patients
ESPEN expert group recommendations for
action against cancer-related malnutrition
Carbohydrates and insulin resistance in
clinical nutrition: recommendations from
the ESPEN expert group
ASPEN safe practices for enteral nutrition
therapy
Lipid injectable emulsion survey with gap
analysis
ESPEN guideline: clinical nutrition in
inflammatory bowel disease
Parenteral nutrition errors and potential
errors reported over the past 10 years
ASPEN-FELANPE clinical guidelines for
enterocutaneous fistula
ACG clinical guideline: evaluation of
abnormal liver chemistries
Guidelines for the provision and assessment
of nutrition support therapy in the
pediatric critically ill patient
Role of nutrition support in adult cardiac
surgery
ESPEN guideline: clinical nutrition in surgery
When is parenteral nutrition appropriate?

or TDA. In the 12-day sample, high-risk patients were found
to have lower mortality for each 10% increase in protein

intake (odds ratio [OR]: 0.9; 95% confidence interval [CI]:
0.84-0.96; P = .003) and each 10% increase in energy intake
(OR: 0.88; 95% CI: 0.83-0.94; P < .001) relative to goal. The
TDA was shorter with greater protein intake (hazard ratio
[HR]: 1.09; 95% CI: 1.03-1.16; P = .002) and for greater
energy intake in high-risk patients (HR: 1.09; 95% CI: 1.031.16; P = .002). Protein and energy intake did not significantly affect mortality or TDA in low-risk patients.
The investigators concluded that critically ill patients
with high NUTRIC scores who stay in the ICU at least 12
days may benefit from greater protein and energy provision. A similar study evaluating the "modified NUTRIC"
tool (also omitting IL-6) found mortality and TDA benefits
in high-risk patients who received greater protein and
energy.26 Previous studies have suggested receiving adequate protein may have a greater impact on outcomes than
achieving energy goals,25,27,28 although this study also supports improved outcomes with provision of adequate energy
intake in high-risk patients. Interestingly, patients in this
study were prescribed 1.2 g/kg/d protein and 24 kcal/kg/d
but received only about 0.7 g/kg/d protein and 16 kcal/kg/d,
which is significantly less than current recommendations.29
This limits the applicability of these results, as the ideal
amount of protein and energy intake required for improved
outcomes, particularly in high nutrition risk and nonmedical ICU patients, remains controversial. This study provides further evidence that the greatest benefit for nutrition
support may be seen in patients at high nutrition risk with
prolonged ICU stays, although randomized trials in more
homogeneous ICU populations are warranted to determine
optimal protein and energy targets for various ICU subsets
with differing levels of nutrition risk.



Table of Contents for the Digital Edition of Hospital Pharmacy - July/August 2018

Ed Board
TOC
Antibiotic Stewardship: The Health of the World Depends on It
ISMP Medication Error Report Analysis: CycloSPORINE Dispensing Errors
ISMP Adverse Drug Reactions
Summaries of Safety Labeling Changes Approved By FDA: Boxed Warnings Highlights January-March 2018
Restructuring a Pharmacy Department: Leadership Strategies for Managing Organizational Change
Angiotensin II
RxLegal: A Rapid Review of Right-To-Try
New Medications in the Treatment of Hereditary Transthyretin Amyloidosis
Significant Published Articles for Pharmacy Nutrition Support Practice in 2017
Utilization of Lean Techniques in Pharmacy Residency Training: Modifying the PGY1 Management and Leadership Experience
Impact of a Clinical Decision Support Tool on Cancer Pain Management in Opioid-Tolerant Inpatients
Lyme Carditis: A Case Report and Review of Management
Impact of the Implementation of Project Re-Engineered Discharge for Heart Failure patients at a Veterans Affairs Hospital at the Central Arkansas Veterans Healthcare System
Evaluation of Oritavancin Use at a Community Hospital
Hospital Pharmacy - July/August 2018 - Cover1
Hospital Pharmacy - July/August 2018 - Cover2
Hospital Pharmacy - July/August 2018 - 201
Hospital Pharmacy - July/August 2018 - 202
Hospital Pharmacy - July/August 2018 - 203
Hospital Pharmacy - July/August 2018 - 204
Hospital Pharmacy - July/August 2018 - 205
Hospital Pharmacy - July/August 2018 - Ed Board
Hospital Pharmacy - July/August 2018 - 207
Hospital Pharmacy - July/August 2018 - TOC
Hospital Pharmacy - July/August 2018 - 209
Hospital Pharmacy - July/August 2018 - 210
Hospital Pharmacy - July/August 2018 - 211
Hospital Pharmacy - July/August 2018 - 212
Hospital Pharmacy - July/August 2018 - 213
Hospital Pharmacy - July/August 2018 - Antibiotic Stewardship: The Health of the World Depends on It
Hospital Pharmacy - July/August 2018 - 215
Hospital Pharmacy - July/August 2018 - 216
Hospital Pharmacy - July/August 2018 - ISMP Medication Error Report Analysis: CycloSPORINE Dispensing Errors
Hospital Pharmacy - July/August 2018 - 218
Hospital Pharmacy - July/August 2018 - 219
Hospital Pharmacy - July/August 2018 - ISMP Adverse Drug Reactions
Hospital Pharmacy - July/August 2018 - 221
Hospital Pharmacy - July/August 2018 - 222
Hospital Pharmacy - July/August 2018 - Summaries of Safety Labeling Changes Approved By FDA: Boxed Warnings Highlights January-March 2018
Hospital Pharmacy - July/August 2018 - 224
Hospital Pharmacy - July/August 2018 - Restructuring a Pharmacy Department: Leadership Strategies for Managing Organizational Change
Hospital Pharmacy - July/August 2018 - 226
Hospital Pharmacy - July/August 2018 - 227
Hospital Pharmacy - July/August 2018 - 228
Hospital Pharmacy - July/August 2018 - 229
Hospital Pharmacy - July/August 2018 - Angiotensin II
Hospital Pharmacy - July/August 2018 - 231
Hospital Pharmacy - July/August 2018 - 232
Hospital Pharmacy - July/August 2018 - 233
Hospital Pharmacy - July/August 2018 - RxLegal: A Rapid Review of Right-To-Try
Hospital Pharmacy - July/August 2018 - 235
Hospital Pharmacy - July/August 2018 - New Medications in the Treatment of Hereditary Transthyretin Amyloidosis
Hospital Pharmacy - July/August 2018 - 237
Hospital Pharmacy - July/August 2018 - 238
Hospital Pharmacy - July/August 2018 - Significant Published Articles for Pharmacy Nutrition Support Practice in 2017
Hospital Pharmacy - July/August 2018 - 240
Hospital Pharmacy - July/August 2018 - 241
Hospital Pharmacy - July/August 2018 - 242
Hospital Pharmacy - July/August 2018 - 243
Hospital Pharmacy - July/August 2018 - 244
Hospital Pharmacy - July/August 2018 - 245
Hospital Pharmacy - July/August 2018 - 246
Hospital Pharmacy - July/August 2018 - Utilization of Lean Techniques in Pharmacy Residency Training: Modifying the PGY1 Management and Leadership Experience
Hospital Pharmacy - July/August 2018 - 248
Hospital Pharmacy - July/August 2018 - 249
Hospital Pharmacy - July/August 2018 - 250
Hospital Pharmacy - July/August 2018 - 251
Hospital Pharmacy - July/August 2018 - 252
Hospital Pharmacy - July/August 2018 - 253
Hospital Pharmacy - July/August 2018 - 254
Hospital Pharmacy - July/August 2018 - 255
Hospital Pharmacy - July/August 2018 - Impact of a Clinical Decision Support Tool on Cancer Pain Management in Opioid-Tolerant Inpatients
Hospital Pharmacy - July/August 2018 - 257
Hospital Pharmacy - July/August 2018 - 258
Hospital Pharmacy - July/August 2018 - 259
Hospital Pharmacy - July/August 2018 - 260
Hospital Pharmacy - July/August 2018 - 261
Hospital Pharmacy - July/August 2018 - 262
Hospital Pharmacy - July/August 2018 - Lyme Carditis: A Case Report and Review of Management
Hospital Pharmacy - July/August 2018 - 264
Hospital Pharmacy - July/August 2018 - 265
Hospital Pharmacy - July/August 2018 - Impact of the Implementation of Project Re-Engineered Discharge for Heart Failure patients at a Veterans Affairs Hospital at the Central Arkansas Veterans Healthcare System
Hospital Pharmacy - July/August 2018 - 267
Hospital Pharmacy - July/August 2018 - 268
Hospital Pharmacy - July/August 2018 - 269
Hospital Pharmacy - July/August 2018 - 270
Hospital Pharmacy - July/August 2018 - 271
Hospital Pharmacy - July/August 2018 - Evaluation of Oritavancin Use at a Community Hospital
Hospital Pharmacy - July/August 2018 - 273
Hospital Pharmacy - July/August 2018 - 274
Hospital Pharmacy - July/August 2018 - 275
Hospital Pharmacy - July/August 2018 - 276
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