Hospital Pharmacy - June 2018 - 160
160
** IV push
** Intermittent IV
infusion
** Continuous IV
infusion
** IM
** Intermittent IV
infusion
** IM
Not approved for IV
push administration
Others
Chloramphenicol
Monobactam
Aztreonam
** IV push
** IV push
** Intermittent IV
infusion
** IM
Glycopeptides/lipoglycopeptides/lipopeptides
Daptomycin
** IV push (adults only)
** Intermittent IV
infusion (adults and
pediatric patients
aged 1 to 17 years)
Cefuroxime
Ceftriaxone
Antibiotic
FDA-approved
administration
Table 1. (continued)
Vials of 1 g: reconstitute with 10 mL of SWFI
or D5W to resulting concentration of 100
mg/mL
No further dilution required
Vials of 1 and 2 g: reconstitute with 6- to
10-mL SWFI
No further dilution required
Cubicin
Cubicin vials: reconstitute with 10 mL of NS
to concentration of 50 mg/mL
No further dilution required
Cubicin RF
Cubicin RF vials: reconstitute with 10 mL
of SWFI or BWFI to concentration of 50
mg/mL
No further dilution required
PI reconstitution
Vials of 250 mg, 500 mg, 1 g, and 2 g:
reconstitute with 2.4-, 4.8-, 9.6-, and 19.2mL SWFI, NS, or D5W, respectively, to a
resulting concentration of 100 mg/mL
(PI recommends further dilution for
administration via IV infusion)
Off-label preparation
McLaughlin 20172:
1 and 2 g diluted in 10 mL SWFI
Poole 199979:
1 g diluted in 10 mL SWFI
Garrelts 198878:
1 g diluted in 10 mL SWFI
Vials 750 mg and 1.5 g: reconstitute with
8.3- and 16-mL SWFI, respectively, to a
resulting concentration of 90 mg/mL
No further dilution required
Off-label preparation
Poole 1999 and Garrelts 198878,79: 750 mg
diluted with 10 mL SWFI
Preparation
Reconstituted vial62,63: 30 d at RT
Reconstituted solutions >20 mg/mL
in SWFI: 48 h at RT and 7 d under
refrigeration
Cubicin
Reconstituted Cubicin vials: 12 h at RT and
48 h under refrigeration
Cubicin RF
Reconstituted Cubicin RF vials: 24 and 48
h at RT in SWFI and BWFI, respectively;
3 d under refrigeration in both SWFI
and BWFI
Polypropylene syringes (with elastomeric
rubber stopper), 50 mg/mL (Cubicin
RF): 24 h and 3 d at RT and under
refrigeration, respectively, when diluted
with SWFI; 48 h and 5 d at RT and under
refrigeration, respectively, when diluted
with BWFI
Reconstituted vials: 24 h at RT and 48 h
under refrigeration
Reconstituted vials (100 mg/mL): 2 d at
25°C and 10 d at 4°C
Polypropylene syringes, 100 mg/mL in
SWFI63,87: 72 h at 20°C; 40 d at 4°C, and
180 d frozen at -20°C
Stabilityb
IV push/IV slow injection
Inject over at least 1 min
Inject over 3 to 5 min, directly into
vein or through the tubing of a
running compatible IV infusion
Cubicin and Cubicin RF
Inject over 2 min
Inject over 3 to 5 min, directly into
vein or through the tubing of a
running compatible IV infusion
Off-label administration
Garrelts 198878: Inject over 1 to
2 min/g
Off-label administration
McLaughlin 20172: Inject over 2 min
(adults only)
Poole 199979: Inject over 2 to 4 min
in those aged >11 years
Garrelts 198878: Inject over 1 to 2
min/g (adults only)
Administration
Notes
(continued)
No relevant syringe stability was located
No relevant syringe stability was located
Cubicin and Cubicin RF
Do not administer by IV push in pediatric and
adolescent patients aged ≤17 years.
2 formulations are available (Cubicin and
Cubicin RF), which have differences in
reconstitution and storage
Cubicin
No relevant syringe stability for Cubicin
formulation was located
Cubicin RF
Do not use saline-based diluents to
reconstitute Cubicin RF; this results in
hyperosmotic solution that may cause
infusion-site reactions when given as IV push
Poole 199979: Evaluated IV push for patientadministered doses at home (OPAT); over
3 to 5 min
Garrelts 198878: Evaluated rates of postinfusion
phlebitis with IV push compared with IV
infusion in a tertiary hospital
No relevant syringe stability was located
McLaughlin 2017 : Evaluated use of IV push for
first dose only in ED
Poole 199979: Evaluated IV push for patientadministered doses at home (OPAT)
Garrelts 198878: Evaluated rates of postinfusion
phlebitis with IV push compared with IV
infusion in a tertiary hospital
2
Table of Contents for the Digital Edition of Hospital Pharmacy - June 2018
Ed Board
TOC
USP <800>
Oct-Dec 2017 Boxed Warning Highlights approved by the FDA
Zoster Vaccine Recombinant, Adjuvanted
Multifactorial Causes of Tacrolimus Errors: Confusion With Strength/Formulation, Look-Alike Names, Preparation Errors, and More
New Medications in the Treatment of Nonalcoholic Steatohepatitis
One Chance for Your Best First Impression: Tips for New Pharmacists
Implications of Statin Use on Vasopressor Therapy in the Setting of Septic Shock
Intravenous Push Administration of Antibiotics: Literature and Considerations
The Role of Computerized Clinical Decision Support in Reducing Inappropriate Medication Administration During Epidural Therapy
Health Care Professionals Toward Adverse Drug Reaction Reporting in Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia: A Cross-sectional Study
Nonpharmacist Health Care Providers’ Knowledge of and Opinions Regarding Medication Costs in Critically Ill Patients
Detection of HBV, HCV, and Incidence of Febrile Neutropenia Associated With CHOP With or Without Rituximab in Diffuse Large B-Cell Lymphoma–Treated Patients
Hospital Pharmacy - June 2018 - Cover1
Hospital Pharmacy - June 2018 - Cover2
Hospital Pharmacy - June 2018 - Ed Board
Hospital Pharmacy - June 2018 - TOC
Hospital Pharmacy - June 2018 - 131
Hospital Pharmacy - June 2018 - USP <800>
Hospital Pharmacy - June 2018 - 133
Hospital Pharmacy - June 2018 - Oct-Dec 2017 Boxed Warning Highlights approved by the FDA
Hospital Pharmacy - June 2018 - 135
Hospital Pharmacy - June 2018 - Zoster Vaccine Recombinant, Adjuvanted
Hospital Pharmacy - June 2018 - 137
Hospital Pharmacy - June 2018 - 138
Hospital Pharmacy - June 2018 - 139
Hospital Pharmacy - June 2018 - 140
Hospital Pharmacy - June 2018 - 141
Hospital Pharmacy - June 2018 - Multifactorial Causes of Tacrolimus Errors: Confusion With Strength/Formulation, Look-Alike Names, Preparation Errors, and More
Hospital Pharmacy - June 2018 - 143
Hospital Pharmacy - June 2018 - 144
Hospital Pharmacy - June 2018 - 145
Hospital Pharmacy - June 2018 - New Medications in the Treatment of Nonalcoholic Steatohepatitis
Hospital Pharmacy - June 2018 - 147
Hospital Pharmacy - June 2018 - One Chance for Your Best First Impression: Tips for New Pharmacists
Hospital Pharmacy - June 2018 - 149
Hospital Pharmacy - June 2018 - 150
Hospital Pharmacy - June 2018 - 151
Hospital Pharmacy - June 2018 - Implications of Statin Use on Vasopressor Therapy in the Setting of Septic Shock
Hospital Pharmacy - June 2018 - 153
Hospital Pharmacy - June 2018 - 154
Hospital Pharmacy - June 2018 - 155
Hospital Pharmacy - June 2018 - 156
Hospital Pharmacy - June 2018 - Intravenous Push Administration of Antibiotics: Literature and Considerations
Hospital Pharmacy - June 2018 - 158
Hospital Pharmacy - June 2018 - 159
Hospital Pharmacy - June 2018 - 160
Hospital Pharmacy - June 2018 - 161
Hospital Pharmacy - June 2018 - 162
Hospital Pharmacy - June 2018 - 163
Hospital Pharmacy - June 2018 - 164
Hospital Pharmacy - June 2018 - 165
Hospital Pharmacy - June 2018 - 166
Hospital Pharmacy - June 2018 - 167
Hospital Pharmacy - June 2018 - 168
Hospital Pharmacy - June 2018 - 169
Hospital Pharmacy - June 2018 - The Role of Computerized Clinical Decision Support in Reducing Inappropriate Medication Administration During Epidural Therapy
Hospital Pharmacy - June 2018 - 171
Hospital Pharmacy - June 2018 - 172
Hospital Pharmacy - June 2018 - 173
Hospital Pharmacy - June 2018 - 174
Hospital Pharmacy - June 2018 - 175
Hospital Pharmacy - June 2018 - 176
Hospital Pharmacy - June 2018 - Health Care Professionals Toward Adverse Drug Reaction Reporting in Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia: A Cross-sectional Study
Hospital Pharmacy - June 2018 - 178
Hospital Pharmacy - June 2018 - 179
Hospital Pharmacy - June 2018 - 180
Hospital Pharmacy - June 2018 - 181
Hospital Pharmacy - June 2018 - 182
Hospital Pharmacy - June 2018 - 183
Hospital Pharmacy - June 2018 - 184
Hospital Pharmacy - June 2018 - 185
Hospital Pharmacy - June 2018 - 186
Hospital Pharmacy - June 2018 - 187
Hospital Pharmacy - June 2018 - Nonpharmacist Health Care Providers’ Knowledge of and Opinions Regarding Medication Costs in Critically Ill Patients
Hospital Pharmacy - June 2018 - 189
Hospital Pharmacy - June 2018 - 190
Hospital Pharmacy - June 2018 - 191
Hospital Pharmacy - June 2018 - 192
Hospital Pharmacy - June 2018 - 193
Hospital Pharmacy - June 2018 - Detection of HBV, HCV, and Incidence of Febrile Neutropenia Associated With CHOP With or Without Rituximab in Diffuse Large B-Cell Lymphoma–Treated Patients
Hospital Pharmacy - June 2018 - 195
Hospital Pharmacy - June 2018 - 196
Hospital Pharmacy - June 2018 - 197
Hospital Pharmacy - June 2018 - 198
Hospital Pharmacy - June 2018 - 199
Hospital Pharmacy - June 2018 - 200
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