Hospital Pharmacy - June 2018 - 161
161
** Slow IV injection
** Intermittent IV
infusion
** IM
Oxacillin
150 mg vial: reconstitute with 2 mL SWFI to
resulting concentration of 75 mg/mL
No further dilution required
Vials of 125, 250, and 500 mg: reconstitute
with 5-mL SWFI or BWFI
Vials of 1 and 2 g: reconstitute with 7.4 or
14.8 mL, respectively, SWFI or BWFI
No further dilution required
Vials of 1.5 and 3.0 g: Reconstitute with
3.2 or 6.4 mL of SWFI, respectively, to a
concentration of 250 mg ampicillin/mL
Further dilute with suitable diluent to a
final concentration of 30 mg ampicillin/
mL (maximum concentration for IV
administration)
Vials of 1 or 2 g: reconstitute, respectively,
with 3.4 or 6.6 mL SWFI, NS, or BWFI
(with benzyl alcohol or parabens) to final
concentration of 250 mg/mL
Further dilute reconstituted solution with at
least 15 to 30 mL SWFI, NS, or ½ NS
Off-label preparation
Poole 199979: 1 g diluted with 25 mL NS (for
central line administration only)
Vials of 1 and 2 g: Reconstitute with 10 or 20
mL, respectively, of SWFI, ½ NS, or NS to
100 mg/mL
No further dilution required
Preparation
Reconstituted vial: 7 d at refrigerated
(2°-8°C) or RT (20°-25°C)
Reconstituted solution (10-100 mg/mL): 4
d at RT and 7 d under refrigeration, in
SWFI and NS
Reconstituted solution (100 mg/mL): 30
d frozen in SWFI and NS (for SWFI,
includes 50-100 mg/mL)
Plastic luer-tip syringes with tubing
attached and capped, 100 mg/mL in NS64:
92 h at RT and 2 wk under refrigeration
Initial reconstituted solution (250 mg/mL):
3 d at RT, 7 d under refrigeration, and
90 d frozen
Stability of further diluted solutions:
10 to 200 mg/mL: 24 h at RT and 7 d under
refrigeration, in SWFI and NS
IM and IV push injections should
be administered within 1 h after
reconstitution as potency may decrease
Additional stability information in text
summary
Reconstituted solution (30 mg ampicillin/
mL), in SWFI or NS: 8 h at 25ºC and 48
h at 4ºC
Stabilityb
IV push/IV slow injection
Inject over 3 to 5 min
Inject over 10 min
Inject over 5 to 10 min,
recommended to be given
through the tubing of a running
compatible IV infusion
Inject over at least 10 to 15 min
Inject over 3 to 5 min for 125-,
250-, and 500-mg doses
Inject over 10 to 15 min for 1- and
2-g doses
Administration
See text summary for additional stability
information
No relevant syringe stability was located
Poole 199979: Evaluated IV push for patientadministered dose at home (OPAT); given
over 5 to 10 min
No relevant syringe stability was located
See PI for detailed information on stability for
various diluents and storage conditions
No relevant syringe stability was located
Administration of ampicillin more rapidly than
recommended may result in convulsive
seizuresc
No relevant syringe stability was located
Notes
Note. FDA = Food and Drug Administration; ½ NS = half-normal saline (0.45% sodium chloride); D5W = dextrose 5% in water; OPAT = outpatient parenteral antibiotic therapy; ED = emergency department; IM = intramuscular;
IV = intravenous; NS = normal saline (0.9% sodium chloride); PI = prescribing information; PK = pharmacokinetic; RT = room temperature; SWFI = sterile water for injection; BWFI = bacteriostatic water for injection; USP =
United States Pharmacopeia.
a
Information sourced from PI unless otherwise noted.
b
For assigning beyond use dates, in addition to stability data, USP <797> recommendations for sterility still apply. The shorter of the times should be used.
c
Clinical Pharmacology reported 100 mg/min as maximum rate; however, this information could not be confirmed in additional resources. In addition, this rate is slower than what would be administered if following PIrecommended dilution and administration.
** IV push
** IV continuous
infusion
** IM injection
** Slow IV injection
** Intermittent IV
infusion
** IM
Nafcillin
Polymyxins
Colistimethate
sodium
** Slow IV injection
** Intermittent IV
infusion
** IM
** IV push
** Slow IV injection
** IM
Ampicillin/
sulbactam
Penicillins
Ampicillin
Antibiotic
FDA-approved
administration
Table 1. (continued)
Table of Contents for the Digital Edition of Hospital Pharmacy - June 2018
Ed Board
TOC
USP <800>
Oct-Dec 2017 Boxed Warning Highlights approved by the FDA
Zoster Vaccine Recombinant, Adjuvanted
Multifactorial Causes of Tacrolimus Errors: Confusion With Strength/Formulation, Look-Alike Names, Preparation Errors, and More
New Medications in the Treatment of Nonalcoholic Steatohepatitis
One Chance for Your Best First Impression: Tips for New Pharmacists
Implications of Statin Use on Vasopressor Therapy in the Setting of Septic Shock
Intravenous Push Administration of Antibiotics: Literature and Considerations
The Role of Computerized Clinical Decision Support in Reducing Inappropriate Medication Administration During Epidural Therapy
Health Care Professionals Toward Adverse Drug Reaction Reporting in Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia: A Cross-sectional Study
Nonpharmacist Health Care Providers’ Knowledge of and Opinions Regarding Medication Costs in Critically Ill Patients
Detection of HBV, HCV, and Incidence of Febrile Neutropenia Associated With CHOP With or Without Rituximab in Diffuse Large B-Cell Lymphoma–Treated Patients
Hospital Pharmacy - June 2018 - Cover1
Hospital Pharmacy - June 2018 - Cover2
Hospital Pharmacy - June 2018 - Ed Board
Hospital Pharmacy - June 2018 - TOC
Hospital Pharmacy - June 2018 - 131
Hospital Pharmacy - June 2018 - USP <800>
Hospital Pharmacy - June 2018 - 133
Hospital Pharmacy - June 2018 - Oct-Dec 2017 Boxed Warning Highlights approved by the FDA
Hospital Pharmacy - June 2018 - 135
Hospital Pharmacy - June 2018 - Zoster Vaccine Recombinant, Adjuvanted
Hospital Pharmacy - June 2018 - 137
Hospital Pharmacy - June 2018 - 138
Hospital Pharmacy - June 2018 - 139
Hospital Pharmacy - June 2018 - 140
Hospital Pharmacy - June 2018 - 141
Hospital Pharmacy - June 2018 - Multifactorial Causes of Tacrolimus Errors: Confusion With Strength/Formulation, Look-Alike Names, Preparation Errors, and More
Hospital Pharmacy - June 2018 - 143
Hospital Pharmacy - June 2018 - 144
Hospital Pharmacy - June 2018 - 145
Hospital Pharmacy - June 2018 - New Medications in the Treatment of Nonalcoholic Steatohepatitis
Hospital Pharmacy - June 2018 - 147
Hospital Pharmacy - June 2018 - One Chance for Your Best First Impression: Tips for New Pharmacists
Hospital Pharmacy - June 2018 - 149
Hospital Pharmacy - June 2018 - 150
Hospital Pharmacy - June 2018 - 151
Hospital Pharmacy - June 2018 - Implications of Statin Use on Vasopressor Therapy in the Setting of Septic Shock
Hospital Pharmacy - June 2018 - 153
Hospital Pharmacy - June 2018 - 154
Hospital Pharmacy - June 2018 - 155
Hospital Pharmacy - June 2018 - 156
Hospital Pharmacy - June 2018 - Intravenous Push Administration of Antibiotics: Literature and Considerations
Hospital Pharmacy - June 2018 - 158
Hospital Pharmacy - June 2018 - 159
Hospital Pharmacy - June 2018 - 160
Hospital Pharmacy - June 2018 - 161
Hospital Pharmacy - June 2018 - 162
Hospital Pharmacy - June 2018 - 163
Hospital Pharmacy - June 2018 - 164
Hospital Pharmacy - June 2018 - 165
Hospital Pharmacy - June 2018 - 166
Hospital Pharmacy - June 2018 - 167
Hospital Pharmacy - June 2018 - 168
Hospital Pharmacy - June 2018 - 169
Hospital Pharmacy - June 2018 - The Role of Computerized Clinical Decision Support in Reducing Inappropriate Medication Administration During Epidural Therapy
Hospital Pharmacy - June 2018 - 171
Hospital Pharmacy - June 2018 - 172
Hospital Pharmacy - June 2018 - 173
Hospital Pharmacy - June 2018 - 174
Hospital Pharmacy - June 2018 - 175
Hospital Pharmacy - June 2018 - 176
Hospital Pharmacy - June 2018 - Health Care Professionals Toward Adverse Drug Reaction Reporting in Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia: A Cross-sectional Study
Hospital Pharmacy - June 2018 - 178
Hospital Pharmacy - June 2018 - 179
Hospital Pharmacy - June 2018 - 180
Hospital Pharmacy - June 2018 - 181
Hospital Pharmacy - June 2018 - 182
Hospital Pharmacy - June 2018 - 183
Hospital Pharmacy - June 2018 - 184
Hospital Pharmacy - June 2018 - 185
Hospital Pharmacy - June 2018 - 186
Hospital Pharmacy - June 2018 - 187
Hospital Pharmacy - June 2018 - Nonpharmacist Health Care Providers’ Knowledge of and Opinions Regarding Medication Costs in Critically Ill Patients
Hospital Pharmacy - June 2018 - 189
Hospital Pharmacy - June 2018 - 190
Hospital Pharmacy - June 2018 - 191
Hospital Pharmacy - June 2018 - 192
Hospital Pharmacy - June 2018 - 193
Hospital Pharmacy - June 2018 - Detection of HBV, HCV, and Incidence of Febrile Neutropenia Associated With CHOP With or Without Rituximab in Diffuse Large B-Cell Lymphoma–Treated Patients
Hospital Pharmacy - June 2018 - 195
Hospital Pharmacy - June 2018 - 196
Hospital Pharmacy - June 2018 - 197
Hospital Pharmacy - June 2018 - 198
Hospital Pharmacy - June 2018 - 199
Hospital Pharmacy - June 2018 - 200
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