Shaklee Product Guide 2015, Issue 2 - 133

CLINICAL RESEARCH // PROOF OF THE PRODUCTS Physique-Maximizing Insulin Response 90 INSULIN (uU/ml) 80 60 40 20 0 Post 30 60 90 120 150 180 210 TIME (minutes) Physique Protein only Carbohydrate only MUSCLE GLYCOGEN STORAGE (umol/g pro/h) Physique-Maximizing Muscle Energy 35 30 The effectiveness of Vital Repair+ complex has been demonstrated in human cell cultures in which free radicals were generated by exposing those cultures to ultraviolet (UV) light. When compared to cell cultures exposed to the same amount of UV light but not treated with Vital Repair+ or its component ingredients, the cell cultures treated with Vital Repair+ were found to exhibit a significantly lower number of cell deaths. All cell culture measurements were made within 48 hours following exposure of the cell cultures to the UV light. These measurements were run in triplicate for each material tested and were conducted using techniques commonly employed in cell culture technology. The reduction in cell death was accompanied by an increased number of living (viable) dividing skin cells in the cultures treated with Vital Repair+. 25 20 15 Conclusion: The activity of this complex of antioxidants clearly demonstrates that Vital Repair+ is effective in blocking the complex cascade of free radical reactions brought about by exposure of skin to UV light. 10 5 0 Physique complex was much greater than the sum of the activity of the individual components or the sum of the activity of those component materials. Carbohydrate only Protein only 1. Zawadzki KM, Yaspelkis III B, Ivy JL. Carbohydrate-protein complex increases the rate of muscle glycogen storage after exercise. J Appl Physiol 1992;72:1854-9. Personal Care Subject: Enfuselle® Product Line (Global Skin Care Program) The introduction of the Enfuselle skin care line has been accompanied by extensive clinical testing, outlined below. For more information, contact your Distributor or Sponsor to obtain a copy of this information, or visit Shaklee.com. Some of the Enfuselle clinical studies utilized contralateral (half-face) studies. Bioinstruments were used to objectively measure the depth of fine lines and wrinkles on one side of the face where Enfuselle was being applied, and these results were compared with the control side where no skin care products or makeup were used. The results of the tests, due in part to the rapidly changing climate conditions, were extraordinary: Where no skin care or cosmetic products were used, the visible signs of aging became measurably deeper, while the skin treated with Enfuselle products steadily improved. In addition to bioinstrumentation, subjects completed a detailed questionnaire following the tests subjectively rating the products' results. Subject: Enfuselle Vital Repair+®: In-Vitro Study of the Effectiveness of a Unique Combination of Known Antioxidants, Vital Repair+, in Human Cell Cultures Enfuselle Vital Repair+: Exhibits significant antioxidant activity in cell cultures of human skin cells exposed to ultraviolet (UV) light. This unique, patented (#6,036,946) combination of ingredients composed of vitamins A, C, and E, along with panthenol, grape seed extract, superoxide dismutase, and beta glucan, has been shown to protect against cellular death caused by exposure to the UV wavelengths of natural sunlight. The activity of this complex was found to be synergistic, that is, the activity of the Subject: Antioxidant Activity of Vital Repair+ from Enfuselle Formulations When Applied to Human Skin Vital Repair+ in Enfuselle Formulations Provides Antioxidant Activity: A test of three of the Enfuselle skin care formulations clearly demonstrates that each formulation exhibits significant antioxidant activity when applied to the surface of intact human skin. The level of antioxidant activity was found to be significantly greater than that of control treated skin without the Vital Repair+. These results clearly demonstrate that the Vital Repair+ present in the Enfuselle skin care formulations exhibits antioxidant activity as demonstrated in the human skin cell cultures. The effectiveness of Vital Repair+ antioxidant complex included in the Enfuselle skin care products was demonstrated in human cell cultures. However, this does not unequivocally ensure this same effectiveness when applied to human skin. Therefore, a test was conducted to show this efficacy on human skin. It is well documented that when beta carotene is exposed to long wavelength ultraviolet (UVA, 320 to 400 nm) radiation, as found in sunlight, it undergoes a free radical reaction during which it changes from an orange color to a pale yellow color. Shaklee scientists used this knowledge to demonstrate the effectiveness of Vital Repair+ from the Enfuselle formulations. Solutions of beta carotene were applied to the forearms of human subjects and allowed to dry completely. The Enfuselle formulations were then applied to selected sites on top of the beta carotene treated sites. All test sites were then exposed to UVA light. The changes in the color of the test sites were then monitored using a Minolta™ Chromameter throughout the UVA exposure period. The color changes in the treated and control sites were exposed to six (6) different intensities of UVA light. Based upon the Chromameter data gathered from this test, the following conclusions were drawn: * Up to twice the antioxidant effectiveness at low UVA doses * Up to three times the antioxidant effectiveness at high UVA doses When compared to cell cultures exposed to UV light in the absence of Vital Repair+, the following data were found: * 40% reduction in the number of cell deaths Additionally, the reduction in the number of cell deaths in the cultures treated with Vital Repair+ was greater than any of the individual components of Vital Repair+ tested separately or the sum of their combined activities. Conclusion: This test clearly demonstrates that Vital Repair+ protects the skin from UVA-induced color change of beta carotene, which is known to occur through a free radical pathway. Therefore, the antioxidant activity of the Vital Repair+ to protect the surface of human skin against free radical damage has been demonstrated. Subject: Enfuselle Instant Firming Serum Instant Firming Serum was evaluated under clinically controlled conditions. Thirty-six women between the ages of 35 and 65 cleansed their face with Enfuselle Hydrating Cleansing Lotion and used Instant Firming Serum only on one-half of their face once a day for 30 days. The treated and untreated sides were randomized to avoid bias. No other makeup or skin care products were worn by the subjects. The subjects were asked to evaluate the efficacy of the product, and trained technicians used instrumental and visual techniques to evaluate the wrinkle and fine lines in the crow's-foot area and the elasticity and firmness of the facial skin. When asked on day one1: 82% of subjects indicated that their face felt firmer in just 10 minutes 79% of subjects indicated that they saw an anti-wrinkle effect in 10 minutes 88% of subjects indicated they had immediate results When the treated side was evaluated by technicians at 10 minutes1: 66% of subjects were reported to have a reduction in wrinkles and fine lines in the crow's-foot area 66% of subjects were reported to have improvement in the firmness of facial skin When asked on day 301: 90% of subjects indicated that their face still felt firmer 81% of subjects still saw an anti-wrinkle effect 78% of subjects continued to see immediate results Conclusion: Subjects report that Instant Firming Serum dramatically reduces the appearance of wrinkles and fine lines and improves skin firmness and elasticity in minutes. The improvements are both immediate and long term. The study results are supported by subjective and objective clinical measurements. 1. Based on unaudited data from a single-blind, half-face, controlled independent study. When compared to control test sites not treated with the Enfuselle formulations, the Vital Repair+ delivers the following effectiveness against UVA induced free radical reactions: 133 http://www.Shaklee.com

Table of Contents for the Digital Edition of Shaklee Product Guide 2015, Issue 2

Contents
Shaklee Product Guide 2015, Issue 2 - Cover1
Shaklee Product Guide 2015, Issue 2 - Cover2
Shaklee Product Guide 2015, Issue 2 - 3
Shaklee Product Guide 2015, Issue 2 - 4
Shaklee Product Guide 2015, Issue 2 - 5
Shaklee Product Guide 2015, Issue 2 - 6
Shaklee Product Guide 2015, Issue 2 - 7
Shaklee Product Guide 2015, Issue 2 - 8
Shaklee Product Guide 2015, Issue 2 - 9
Shaklee Product Guide 2015, Issue 2 - 10
Shaklee Product Guide 2015, Issue 2 - Contents
Shaklee Product Guide 2015, Issue 2 - 12
Shaklee Product Guide 2015, Issue 2 - 13
Shaklee Product Guide 2015, Issue 2 - 14
Shaklee Product Guide 2015, Issue 2 - 15
Shaklee Product Guide 2015, Issue 2 - 16
Shaklee Product Guide 2015, Issue 2 - 17
Shaklee Product Guide 2015, Issue 2 - 18
Shaklee Product Guide 2015, Issue 2 - 19
Shaklee Product Guide 2015, Issue 2 - 20
Shaklee Product Guide 2015, Issue 2 - 21
Shaklee Product Guide 2015, Issue 2 - 22
Shaklee Product Guide 2015, Issue 2 - 23
Shaklee Product Guide 2015, Issue 2 - 24
Shaklee Product Guide 2015, Issue 2 - 25
Shaklee Product Guide 2015, Issue 2 - 26
Shaklee Product Guide 2015, Issue 2 - 27
Shaklee Product Guide 2015, Issue 2 - 28
Shaklee Product Guide 2015, Issue 2 - 29
Shaklee Product Guide 2015, Issue 2 - 30
Shaklee Product Guide 2015, Issue 2 - 31
Shaklee Product Guide 2015, Issue 2 - 32
Shaklee Product Guide 2015, Issue 2 - 33
Shaklee Product Guide 2015, Issue 2 - 34
Shaklee Product Guide 2015, Issue 2 - 35
Shaklee Product Guide 2015, Issue 2 - 36
Shaklee Product Guide 2015, Issue 2 - 37
Shaklee Product Guide 2015, Issue 2 - 38
Shaklee Product Guide 2015, Issue 2 - 39
Shaklee Product Guide 2015, Issue 2 - 40
Shaklee Product Guide 2015, Issue 2 - 41
Shaklee Product Guide 2015, Issue 2 - 42
Shaklee Product Guide 2015, Issue 2 - 43
Shaklee Product Guide 2015, Issue 2 - 44
Shaklee Product Guide 2015, Issue 2 - 45
Shaklee Product Guide 2015, Issue 2 - 46
Shaklee Product Guide 2015, Issue 2 - 47
Shaklee Product Guide 2015, Issue 2 - 48
Shaklee Product Guide 2015, Issue 2 - 49
Shaklee Product Guide 2015, Issue 2 - 50
Shaklee Product Guide 2015, Issue 2 - 51
Shaklee Product Guide 2015, Issue 2 - 52
Shaklee Product Guide 2015, Issue 2 - 53
Shaklee Product Guide 2015, Issue 2 - 54
Shaklee Product Guide 2015, Issue 2 - 55
Shaklee Product Guide 2015, Issue 2 - 56
Shaklee Product Guide 2015, Issue 2 - 57
Shaklee Product Guide 2015, Issue 2 - 58
Shaklee Product Guide 2015, Issue 2 - 59
Shaklee Product Guide 2015, Issue 2 - 60
Shaklee Product Guide 2015, Issue 2 - 61
Shaklee Product Guide 2015, Issue 2 - 62
Shaklee Product Guide 2015, Issue 2 - 63
Shaklee Product Guide 2015, Issue 2 - 64
Shaklee Product Guide 2015, Issue 2 - 65
Shaklee Product Guide 2015, Issue 2 - 66
Shaklee Product Guide 2015, Issue 2 - 67
Shaklee Product Guide 2015, Issue 2 - 68
Shaklee Product Guide 2015, Issue 2 - 69
Shaklee Product Guide 2015, Issue 2 - 70
Shaklee Product Guide 2015, Issue 2 - 71
Shaklee Product Guide 2015, Issue 2 - 72
Shaklee Product Guide 2015, Issue 2 - 73
Shaklee Product Guide 2015, Issue 2 - 74
Shaklee Product Guide 2015, Issue 2 - 75
Shaklee Product Guide 2015, Issue 2 - 76
Shaklee Product Guide 2015, Issue 2 - 77
Shaklee Product Guide 2015, Issue 2 - 78
Shaklee Product Guide 2015, Issue 2 - 79
Shaklee Product Guide 2015, Issue 2 - 80
Shaklee Product Guide 2015, Issue 2 - 81
Shaklee Product Guide 2015, Issue 2 - 82
Shaklee Product Guide 2015, Issue 2 - 83
Shaklee Product Guide 2015, Issue 2 - 84
Shaklee Product Guide 2015, Issue 2 - 85
Shaklee Product Guide 2015, Issue 2 - 86
Shaklee Product Guide 2015, Issue 2 - 87
Shaklee Product Guide 2015, Issue 2 - 88
Shaklee Product Guide 2015, Issue 2 - 89
Shaklee Product Guide 2015, Issue 2 - 90
Shaklee Product Guide 2015, Issue 2 - 91
Shaklee Product Guide 2015, Issue 2 - 92
Shaklee Product Guide 2015, Issue 2 - 93
Shaklee Product Guide 2015, Issue 2 - 94
Shaklee Product Guide 2015, Issue 2 - 95
Shaklee Product Guide 2015, Issue 2 - 96
Shaklee Product Guide 2015, Issue 2 - 97
Shaklee Product Guide 2015, Issue 2 - 98
Shaklee Product Guide 2015, Issue 2 - 99
Shaklee Product Guide 2015, Issue 2 - 100
Shaklee Product Guide 2015, Issue 2 - 101
Shaklee Product Guide 2015, Issue 2 - 102
Shaklee Product Guide 2015, Issue 2 - 103
Shaklee Product Guide 2015, Issue 2 - 104
Shaklee Product Guide 2015, Issue 2 - 105
Shaklee Product Guide 2015, Issue 2 - 106
Shaklee Product Guide 2015, Issue 2 - 107
Shaklee Product Guide 2015, Issue 2 - 108
Shaklee Product Guide 2015, Issue 2 - 109
Shaklee Product Guide 2015, Issue 2 - 110
Shaklee Product Guide 2015, Issue 2 - 111
Shaklee Product Guide 2015, Issue 2 - 112
Shaklee Product Guide 2015, Issue 2 - 113
Shaklee Product Guide 2015, Issue 2 - 114
Shaklee Product Guide 2015, Issue 2 - 115
Shaklee Product Guide 2015, Issue 2 - 116
Shaklee Product Guide 2015, Issue 2 - 117
Shaklee Product Guide 2015, Issue 2 - 118
Shaklee Product Guide 2015, Issue 2 - 119
Shaklee Product Guide 2015, Issue 2 - 120
Shaklee Product Guide 2015, Issue 2 - 121
Shaklee Product Guide 2015, Issue 2 - 122
Shaklee Product Guide 2015, Issue 2 - 123
Shaklee Product Guide 2015, Issue 2 - 124
Shaklee Product Guide 2015, Issue 2 - 125
Shaklee Product Guide 2015, Issue 2 - 126
Shaklee Product Guide 2015, Issue 2 - 127
Shaklee Product Guide 2015, Issue 2 - 128
Shaklee Product Guide 2015, Issue 2 - 129
Shaklee Product Guide 2015, Issue 2 - 130
Shaklee Product Guide 2015, Issue 2 - 131
Shaklee Product Guide 2015, Issue 2 - 132
Shaklee Product Guide 2015, Issue 2 - 133
Shaklee Product Guide 2015, Issue 2 - 134
Shaklee Product Guide 2015, Issue 2 - 135
Shaklee Product Guide 2015, Issue 2 - 136
Shaklee Product Guide 2015, Issue 2 - 137
Shaklee Product Guide 2015, Issue 2 - 138
Shaklee Product Guide 2015, Issue 2 - 139
Shaklee Product Guide 2015, Issue 2 - 140
Shaklee Product Guide 2015, Issue 2 - 141
Shaklee Product Guide 2015, Issue 2 - 142
Shaklee Product Guide 2015, Issue 2 - Cover3
Shaklee Product Guide 2015, Issue 2 - Cover4
http://www.nxtbook.com/nxtbooks/shaklee/2020productguide
http://www.nxtbook.com/nxtbooks/shaklee/2019productguide
http://www.nxtbook.com/nxtbooks/shaklee/2018productguide
http://www.nxtbook.com/nxtbooks/shaklee/2017referenceguide
http://www.nxtbook.com/nxtbooks/shaklee/2017productguide
http://www.nxtbook.com/nxtbooks/shaklee/2016productguide1
http://www.nxtbook.com/nxtbooks/shaklee/2016productguide2
http://www.nxtbook.com/nxtbooks/shaklee/2015productguide2
http://www.nxtbook.com/nxtbooks/shaklee/2015productguide1
http://www.nxtbook.com/nxtbooks/shaklee/2014productguide2
http://www.nxtbook.com/nxtbooks/shaklee/2014productguide1
http://www.nxtbook.com/nxtbooks/shaklee/2013productguide
http://www.nxtbook.com/nxtbooks/shaklee/2013productguide_old
http://www.nxtbook.com/nxtbooks/shaklee/2012productguide_v2
http://www.nxtbook.com/nxtbooks/shaklee/2012productguide
http://www.nxtbookMEDIA.com