Shaklee Product Catalogue 2015 - Canada/English - 87

CLINICAL RESEARCH | pRoof of the pRoductS Personal Care Subject: Enfuselle® Product Line (Global Skin Care Program) The introduction of the Enfuselle® skin care line has been accompanied by extensive clinical testing, outlined below. For more information, contact your Distributor or Sponsor to obtain a copy of this information, or visit Shaklee.com. Some of the Enfuselle® clinical studies utilized contralateral (half-face) studies. Bioinstruments were used to objectively measure the depth of fine lines and wrinkles on one side of the face where Enfuselle® was being applied and compared these results to the control side where no skin care products or makeup were used. The results of the tests, due in part to the rapidly changing climate conditions, were extraordinary: where no skin care or cosmetic products were used, the visible signs of aging became measurably deeper, while the skin treated with Enfuselle® products steadily improved. In addition to bioinstrumentation, subjects completed a detailed questionnaire following the tests subjectively rating the products' results. Subject: Enfuselle Vital Repair+® Complex: In vitro study of the effectiveness of a unique combination of known antioxidants, Vital Repair+®, in human cell cultures Enfuselle® Vital Repair+® complex: Exhibits significant antioxidant activity in cell cultures of human skin cells exposed to ultraviolet (UV) light. This unique, patented (#6,036,946) combination of ingredients composed of vitamins A, C, and E, along with panthenol, grapeseed extract, superoxide dismutase, and beta glucan, has been shown to protect against cellular death caused by exposure to the UV wavelengths of natural sunlight. The activity of this complex was found to be synergistic, that is, the activity of the complex was much greater than the sum of the activity of the individual components or the sum of the activity of those component materials. The effectiveness of Vital Repair+® complex has been demonstrated in human cell cultures in which free radicals were generated by exposing those cultures to ultraviolet (UV) light. When compared to cell cultures exposed to the same amount of UV light but not treated with Vital Repair+® complex or its component ingredients, the cell cultures treated with Vital Repair+® complex were found to exhibit a significantly lower number of cell deaths. All cell culture measurements were made within 48 hours following exposure of the cell cultures to the UV light. These measurements were run in triplicate for each material tested and were conducted using techniques commonly employed in cell culture technology. The reduction in cell death was accompanied by an increased number of living (viable) dividing skin cells in the cultures treated with Vital Repair+® complex. Conclusion: The activity of this complex of antioxidants clearly demonstrates that Vital Repair+® is effective in blocking the complex cascade of free radical reactions brought about by exposure of skin to UV light. Subject: Antioxidant Activity of Vital Repair+® Complex From Enfuselle® Formulations When Applied to Human Skin Vital Repair+® complex in Enfuselle® Formulations Provides Antioxidant Activity: A test of three of the Enfuselle® skin care formulations clearly demonstrates that each formulation exhibits significant antioxidant activity when applied to the surface of intact human skin. The level of antioxidant activity was found to be significantly greater than that of control treated skin without the Vital Repair+® complex. These results clearly demonstrate that the Vital Repair+® complex present in the Enfuselle® skin care formulations exhibits antioxidant activity as demonstrated in the human skin cell cultures. The effectiveness of Vital Repair+® complex antioxidant complex included in the Enfuselle® skin care products was demonstrated in human cell cultures. However, this does not unequivocally ensure this same effectiveness when applied to human skin. Therefore, a test was conducted to show this efficacy on human skin. It is well documented that when beta carotene is exposed to long wavelength ultraviolet (UVA, 320 to 400 nm) radiation, as found in sunlight, it undergoes a free radical reaction during which it changes from an orange colour to a pale yellow colour. Shaklee scientists used this knowledge to demonstrate the effectiveness of Vital Repair+® complex from the Enfuselle® formulations. Solutions of beta carotene were applied to the forearms of human subjects and allowed to dry completely. The Enfuselle® formulations were then applied to selected sites on top of the beta carotene treated sites. All test sites were then exposed to UVA light. The changes in the colour of the test sites were then monitored using a Minolta™ Chromameter throughout the UVA exposure period. The colour changes in the treated and control sites were exposed to six (6) different intensities of UVA light. Based upon the Chromameter data gathered from this test, the following conclusions were drawn: When compared with control test sites not treated with the Enfuselle® formulations, the Vital Repair+® complex delivers the following effectiveness against UVA-induced free radical reactions: * Up to twice the antioxidant effectiveness at low UVA doses * Up to three times the antioxidant effectiveness at high UVA doses When compared with cell cultures exposed to UV light in the absence of Vital Repair+® complex, the following data were found: * 40% reduction in the number of cell deaths Additionally, the reduction in the number of cell deaths in the cultures treated with Vital Repair+® complex was greater than any of the individual components of Vital Repair+® complex tested separately or the sum of their combined activities. They found that under the conditions of the test, the product was safe for use, even by contact lens users. * 120% increase in skin resilience and firmness in 14 days * 209% decrease in visible fine lines of the skin in 56 days * 223% decrease in appearance of skin wrinkles in 14 days * 32% increase in retained skin moisture in 56 days * A definitive evening of skin tone in 84 days Conclusion: Enfuselle® Eye Treatment significantly improves skin firmness and resilience, and dramatically improves the texture of eye-area skin while significantly reducing the visible signs of aging of all skin types. Enfuselle® Has Been Awarded Seven U.S. Patents, With One Patent Pending * U.S. Patent #6,015,548: "High-efficiency skin protection formulation with sunscreen agents and antioxidants." * U.S. Patent #6,036,946: "Methods for protecting skin from damaging effects of ultraviolet light." * U.S. Patents #6,174,519, #6,235, 272: "Composition for protecting skin from damaging effects of ultraviolet light." * U.S. Patent #6,146,664: "Stable topical ascorbic acid compositions." * U.S. Patent #6,403,110: "Topical treatment for oily skin." * U.S. Patent #6,723,688: "Cleanser and bar gentle to human skin." For more clinical data please visit Shaklee.com. Reference: Data on File, Shaklee Corporation. Conclusion: This test clearly demonstrates that Vital Repair+® complex protects the skin from UVA-induced colour change of beta carotene, which is known to occur through a free radical pathway. Therefore, the antioxidant activity of the Vital Repair+® complex to protect the surface of human skin against free radical damage has been demonstrated. Subject: Enfuselle® Eye Treatment Enfuselle® Eye Treatment was evaluated under clinically controlled conditions. Twenty-three men and women between the ages of 30 and 70 used Enfuselle® Eye Treatment for a period of 84 days. The product was applied to the skin around one eye, in a controlled and supervised manner. The skin around the other eye area served as the control. The treated and untreated sides were randomized to avoid bias. Subjects were only allowed to cleanse the untreated side with their normal cleanser. No makeup or other skin care products were worn by the subjects. Approximately 50% of the panel were contact lens wearers. The safety of Enfuselle® Eye Treatment was evaluated by a board-certified dermatologist and ophthalmologist. To order, call your Shaklee Independent Distributor, visit SHAKLEE.CA, or call 1.800.263.6674 87 http://www.Shaklee.com http://www.Shaklee.com http://www.SHAKLEE.CA

Table of Contents for the Digital Edition of Shaklee Product Catalogue 2015 - Canada/English

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