Visions - Summer 2009 - 7

Chemicals & Electronics/Business Investment Groups SCOA Synergy Helps Fight Kidney Disease on Two Fronts Business Investment and Life Science Units Work To Help Develop & Distribute New Drug I n September 2008, the National Kidney Foundation stated that more than 26 million Americans over the age of 20 have Chronic Kidney Disease (CKD), and nearly 40% of Americans above 60 years of age have CKD. About 76,600 patients are awaiting kidney transplants in the U.S., and 18 people die every day while waiting for a transplant. Japan’s statistics reflect a worse predicament; studies based on several community-based screening programs suggest that Japan has a higher prevalence of CKD than any other country. SCOA is participating in the fight against this epidemic by using its financing and distribution capabilities to advance a promising development-stage biotechnology drug. Dallas Texas based, Reata Pharmaceuticals is a portfolio company of Oxford Finance, SCOA’s life science venture finance subsidiary. In 2008, Oxford Finance provided $9.5 million dollars in financing to facilitate the company’s clinical trials of RTA-402, a CKD-fighting drug undergoing clinical trials. Later that year, SCOA’s Business Investment Department provided introductions between Reata and representatives of SCOA’s Life Sciences Unit, and helped the Unit in obtaining an exclusive right to market RTA-402 to Japanese pharmaceutical companies. “This pharmaceutical has the potential of becoming a blockbuster drug against CKD,” saidYasunori Ishibashi, Senior Director of Life Science Unit. To understand the impact, one must understand the job of the human kidney.The main function of the kidney is to remove waste products from the blood.When this function is impeded, the consequences are dire, and the danger of CKD is that it is a progressive disease which has few noticeable symptoms and no known cure.When CKD is present, kidney function is impaired gradually, so by the time symptoms are detectable, significant damage has already occurred, and the body runs the risk of kidney failure.The failure of a kidney can be fatal condition because toxic substances begin to build up in the body and cannot be filtered out of the blood. In the end stages of CKD, patients need dialysis in order to merely stay alive. “Originally, this drug was developed for cancer treatment, and during the initial clinical trials, doctors found that the patients’ kidneys were affected positively -- that the patients’ kidney functions improved.” Ishibashi said.“So after the initial introductions, we approached Reata, saying we can introduce this to the Japanese, and soon we made an exclusive agreement to introduce this drug to the Japanese pharmaceutical world. Many companies have already shown interest from the available data, since this drug drastically improved the kidney functions of the patients to which it was administered.” Reata Pharmaceuticals, a company that operates with a moderately small workforce, doesn’t have the manpower for licensing, according to Ishibashi, so an opportunity presented Sumitomo Corporation of America 7

Table of Contents for the Digital Edition of Visions - Summer 2009

Contents
Visions - Summer 2009
The Power of Wind Meets The Power of Business
The Space Age Metal With Mettle
SCOA Synergy Helps Fight Kidney Disease on Two Fronts
Man's Best Friend Gets Relief From New Flea Product
The View From Washington
Visions - Summer 2009 - Visions - Summer 2009
Visions - Summer 2009 - 2
Visions - Summer 2009 - The Power of Wind Meets The Power of Business
Visions - Summer 2009 - 4
Visions - Summer 2009 - The Space Age Metal With Mettle
Visions - Summer 2009 - 6
Visions - Summer 2009 - SCOA Synergy Helps Fight Kidney Disease on Two Fronts
Visions - Summer 2009 - 8
Visions - Summer 2009 - Man's Best Friend Gets Relief From New Flea Product
Visions - Summer 2009 - 10
Visions - Summer 2009 - The View From Washington
Visions - Summer 2009 - 12
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