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[8] K. A. Powell, A. N. Saleemi, C. D. Rielly and Z. K. Nagy,
" Monitoring continuous crystallization of paracetamol in the
presence of an additive using an integrated PAT array and
multivariate methods, " Org. Process Res. Dev., vol. 20, no. 3, pp.
626-636, 2016.
[9] L. Helmdach, M. P. Feth, C. Minnich and J. Ulrich, " Application of
ATR-MIR spectroscopy in the pilot plant-scope and limitations
using the example of paracetamol crystallizations, " Chem. Eng.
Process. Process Intensif., vol. 70, pp. 184-197, 2013.
[10] I.-C. Wang, M.-J. Lee, D.-Y. Seo, H.-E. Lee, Y. Choi, W.-S. Kim,
C.-S. Kim, M.-Y. Jeong and G.J. Choi, " Polymorph transformation
in paracetamol monitored by in-line NIR spectroscopy during a
cooling crystallization process, " AAPS PharmSciTech., vol. 12, no.
2, pp. 764-770, 2011.
[11] E. Hecht, Optics, 5th ed. New York, NY, USA: Pearson, 2016.
[12] F. Ferreira, J.A. Teixeira, and F. Castro, " Modular oscillatory flow
plate reactor, " Patent PT 109314 H (2016); PCT/IB2017/052005
(2017); US 16/092,010, EP3439773 (2018).
[13] P. Cruz, F. Rocha and A. Ferreira, " Determination of the critical
mixing intensity for secondary nucleation of paracetamol in an
oscillatory flow crystallizer, " Cryst. Eng. Comm., vol. 20, pp. 829836,
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[14] M. Jiang and X.-W. Ni, " Reactive crystallization of paracetamol
in a continuous oscillatory baffled reactor, " Org. Process Res. Dev.,
vol. 23, no. 5, pp. 882-890, 2019.
Liliana Soares (liliana.p.soares@inesctec.pt) is currently a
Ph.D. student in the Doctoral Program in Physical Engineering
in the field of optical sensors for biomedical applications at
the Institute for Systems and Computer Engineering, Technology
and Science, Porto, Portugal. She graduated in biomedical
engineering from Polytechnic of Porto, School of Engineering,
in 2017, and she received her master's degree in biomedical
engineering from Catholic University of Portugal, School of
Biotechnology, in 2020.
Patrícia Cruz (pcruz@fe.up.pt) is a Ph.D. student in the
Doctoral Program in Chemical and Biological Engineering
at the Laboratory for Process Engineering, Environment,
Biotechnology and Energy, Porto, Portugal. She has been
developing her research on the continuous crystallization
of active pharmaceutical ingredients in oscillatory flow
crystallizers, in collaboration with industry. She received her
master's degree in chemical engineering from the University
of Porto in 2015.
Susana Novais (susana.novais@inesctec.pt) is currently an
Assistant Researcher in the Center for Applied Photonics at
Institute for Systems and Computer Engineering, Technology
and Science, Porto, Portugal. Her research interests include
new optical fiber designs for sensing and their applications in
medical and environment conditions. She received the Ph.D.
degree in physics engineering (optics and photonics) from
Aveiro University, Aveiro, Portugal in 2019.
António Ferreira (antonio@fe.up.pt) has been a Research Fellow
and Lecturer of chemistry with the Laboratory of Process
Engineering, Environment, Biotechnology and Energy, University
of Porto, Portugal since 2015. He is responsible for
several projects and protocols established with the industry
and research groups in the areas of continuous crystallization
and multiphase reactors. He graduated in industrial chemistry
from the University of Beira Interior, Portugal in 2001 and completed
a Ph.D. degree in chemical and biological engineering at
the University of Porto, Portugal in 2008.
Orlando Frazão (orlando.frazao@inesctec.pt) is a Senior Researcher
with the Optoelectronics and Electronic Systems
Unit, Institute for Systems and Computer Engineering, Technology
and Science, Porto, Portugal. His present research
interests include optical fiber sensors and optical communications.
He received the " Licenciatura " in physical engineering
in Aveiro University in 1999 and the Ph.D. degree in physics
from the Porto University in 2009. From 1997 to 1998, he was
with the Institute of Telecommunications, Aveiro.
Susana Silva (susana.o.silva@inesctec.pt) is currently an
Assistant Researcher in the Center for Applied Photonics, Institute
for Systems and Computer Engineering, Technology
and Science, Porto, Portugal. Her current research interests are
optical sensors for biomedical sensing and distributed fiber
optic sensing for biodiversity applications. She graduated in
applied physics from the University of Porto, Portugal where
she received the Ph.D. degree in 2013.
40
IEEE Instrumentation & Measurement Magazine
August 2021

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